Magnetic resonance imaging-guided brachytherapy for cervical cancer: initiating a program

Owrangi, Amir; Prisciandaro, Joann I.; Soliman, A; Ravi, Ananth; Song, William Y.

doi:10.5114/jcb.2015.55541

Cited by 21 publications

(13 citation statements)

References 55 publications

(88 reference statements)

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“…MRI has been reported to be used in many interventional procedures such as biopsies, thermal therapy or brachytherapy in many sites [40,71,84,90,91]. A few articles have reported various experiences using MRI for brachytherapy and the major indications are for gynecologic and prostate cancers [91][92][93][94][95]. Findings of a study by Buch et al suggested that the volume contours derived from CT was overestimated compared to that from high resolution contrast enhanced magnetic resonance imaging (HR-CEMRI) in 11 postbrachytherapy prostate cancer patients [92].…”

Section: Mrimentioning

confidence: 99%

WITHDRAWN: Image-guided navigation systems for interstitial brachytherapy

Hu¹,

Yu²

2018

Oncotarget

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Interstitial brachytherapy has shown quite promising therapeutic effects in the treatment of tumors in various body regions. Prior to the navigation techniques with quantitative imaging feedback during the procedure, the safety and accuracy of interstitial brachytherapy mainly depended upon the operator's experience, spatial skills and mind reconstruction of the anatomical structures. Different navigation systems have been reported to be experimented on various phantoms and clinically applied in the brachytherapy of many anatomic sites. The numerous advancements of navigation systems integrated with multiple imaging modalities increase accuracy and standardization of the brachytherapy procedure, guarantee clinical effects and even enable less experienced operators to deliver a precise procedure. This article reviews the existing navigation systems and techniques for brachytherapy and discusses the relevant clinical applications.

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Section: Mrimentioning

confidence: 99%

WITHDRAWN: Image-guided navigation systems for interstitial brachytherapy

Hu¹,

Yu²

2018

Oncotarget

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“…It also requires additional resources such as real-time MRI/CT scans, MRI/CT compatible applicators, and availability of 3D treatment planning systems [14]. The additional costs of setting up IGBT are about 10-15% more than the normal costs of the conventional brachytherapy procedure [15].…”

Section: Purposementioning

confidence: 99%

Improving the efficiency of image guided brachytherapy in cervical cancer

Otter¹,

Franklin²,

Ajaz³

et al. 2016

jcb

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Brachytherapy is an essential component of the treatment of locally advanced cervical cancers. It enables the dose to the tumor to be boosted whilst allowing relative sparing of the normal tissues. Traditionally, cervical brachytherapy was prescribed to point A but since the GEC-ESTRO guidelines were published in 2005, there has been a move towards prescribing the dose to a 3D volume. Image guided brachytherapy has been shown to reduce local recurrence, and improve survival and is optimally predicated on magnetic resonance imaging. Radiological studies, patient workflow, operative parameters, and intensive therapy planning can represent a challenge to clinical resources. This article explores the ways, in which 3D conformal brachytherapy can be implemented and draws findings from recent literature and a well-developed hospital practice in order to suggest ways to improve the efficiency and efficacy of a brachytherapy service. Finally, we discuss relatively underexploited translational research opportunities.

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“…This is another limitation of our study, since no dose-volume parameters were considered in this analysis. Nevertheless, during this period, it was possible to establish a new routine for applicator placement and fixation (with only local anesthesia and sedation), to establish a method for transportation of the patient to the imaging rooms, and to training of tumor volumes contouring in MRI, as well as develop all the process for implementation of an IGBT programme [ 18 ]. The tumor shrinking kinetics approach was used to establish better timing for the procedure and to possibly save some resources.…”

Section: Discussionmentioning

confidence: 99%

Implementation of image-guided brachytherapy (IGBT) for patients with uterine cervix cancer: a tumor volume kinetics approach

Carvalho¹,

Mendez²,

Stuart³

et al. 2016

jcb

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PurposeTo evaluate tumor shrinking kinetics in order to implement image-guided brachytherapy (IGBT) for the treatment of patients with cervix cancer.Material and methodsThis study has prospectively evaluated tumor shrinking kinetics of thirteen patients with uterine cervix cancer treated with combined chemoradiation. Four high dose rate brachytherapy fractions were delivered during the course of pelvic external beam radiation therapy (EBRT). Magnetic resonance imaging (MRI) exams were acquired at diagnosis (D), first (B1), and third (B3) brachytherapy fractions. Target volumes (GTV and HR-CTV) were calculated by both the ellipsoid formula (VE) and MRI contouring (VC), which were defined by a consensus between at least two radiation oncologists and a pelvic expert radiologist.ResultsMost enrolled patients had squamous cell carcinoma and FIGO stage IIB disease, and initiated brachytherapy after the third week of pelvic external beam radiation. Gross tumor volume volume reduction from diagnostic MRI to B1 represented 61.9% and 75.2% of the initial volume, when measured by VE and VC, respectively. Only a modest volume reduction (15-20%) was observed from B1 to B3.ConclusionsThe most expressive tumor shrinking occurred in the first three weeks of oncological treatment and was in accordance with gynecological examination. These findings may help in IGBT implementation.

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Magnetic resonance imaging-guided brachytherapy for cervical cancer: initiating a program

Cited by 21 publications

References 55 publications

WITHDRAWN: Image-guided navigation systems for interstitial brachytherapy

WITHDRAWN: Image-guided navigation systems for interstitial brachytherapy

Improving the efficiency of image guided brachytherapy in cervical cancer

Implementation of image-guided brachytherapy (IGBT) for patients with uterine cervix cancer: a tumor volume kinetics approach

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