Magnetic resonance imaging for the ophthalmologist: A primer

Simha, Arathi; Irodi, Aparna; David, Sachin

doi:10.4103/0301-4738.98711

Cited by 5 publications

(1 citation statement)

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“…In vivo diagnostic MRI of the eye, EOMs, and optic nerve has also mostly been restricted to static imaging with fixed gazes. 10 – 12 Motion is generally considered to be a confound rather than the point of interest and therefore clinical MRI is often performed under cued blinking where data are not acquired during periods of rest inserted during the scan. However, imaging of the motion of the eye, EOMs, and optic nerve can be potentially useful in understanding a range of ocular pathologies.…”

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confidence: 99%

Dynamic Imaging of the Eye, Optic Nerve, and Extraocular Muscles With Golden Angle Radial MRI

Sengupta

Smith

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PurposeThe eye and its accessory structures, the optic nerve and the extraocular muscles, form a complex dynamic system. In vivo magnetic resonance imaging (MRI) of this system in motion can have substantial benefits in understanding oculomotor functioning in health and disease, but has been restricted to date to imaging of static gazes only. The purpose of this work was to develop a technique to image the eye and its accessory visual structures in motion.MethodsDynamic imaging of the eye was developed on a 3-Tesla MRI scanner, based on a golden angle radial sequence that allows freely selectable frame-rate and temporal-span image reconstructions from the same acquired data set. Retrospective image reconstructions at a chosen frame rate of 57 ms per image yielded high-quality in vivo movies of various eye motion tasks performed in the scanner. Motion analysis was performed for a left–right version task where motion paths, lengths, and strains/globe angle of the medial and lateral extraocular muscles and the optic nerves were estimated.ResultsOffline image reconstructions resulted in dynamic images of bilateral visual structures of healthy adults in only ∼15-s imaging time. Qualitative and quantitative analyses of the motion enabled estimation of trajectories, lengths, and strains on the optic nerves and extraocular muscles at very high frame rates of ∼18 frames/s.ConclusionsThis work presents an MRI technique that enables high-frame-rate dynamic imaging of the eyes and orbital structures. The presented sequence has the potential to be used in furthering the understanding of oculomotor mechanics in vivo, both in health and disease.

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confidence: 99%