Magnetic resonance imaging findings in 40 dogs with histologically confirmed intracranial tumours

Ródenas, Sergio; Pumarola, M.; Gaitero, Lluís; Zamora, A. Chevez; Añor, S.

doi:10.1016/j.tvjl.2009.10.011

Cited by 100 publications

(209 citation statements)

References 11 publications

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“…In both human and veterinary medicine, the pattern of contrast enhancement has been used to evaluate tumor type,4, 5 predict seizure risk in cases of intracranial neoplasia,31 and differentiate neoplastic from non‐neoplastic lesions, such as postoperative scar tissue, irradiation injury, inflammation or cerebrovascular lesions 3, 32, 33. However, contrast enhancement patterns do not consistently reflect the histologic features of an intracranial lesion, with no association between MR images and histologic findings in approximately 25% of cases in 1 veterinary study 34…”

Section: Discussionmentioning

confidence: 99%

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Exclusion of a Brain Lesion: Is Intravenous Contrast Administration Required after Normal Precontrast Magnetic Resonance Imaging?

Ives

Rousset

Heliczer

et al. 2014

Veterinary Internal Medicne

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BackgroundNo evidence‐based guidelines are available for the administration of gadolinium‐based contrast media to veterinary patients.ObjectiveTo investigate whether administration of intravenous (IV) contrast media alters the likelihood of identifying a brain lesion in dogs and cats.AnimalsFour hundred and eighty‐seven client‐owned animals referred for investigation of intracranial disease.MethodsTwo reviewers retrospectively analyzed precontrast transverse and sagittal T1‐weighted (T1W), T2‐weighted, and fluid‐attenuated inversion recovery low‐field MRI sequences from each patient for the presence of a clinically relevant brain lesion. All sequences subsequently were reviewed in the same manner with additional access to postcontrast T1W images.ResultsOf the 487 precontrast MRI studies, 312 were judged to be normal by 1 or both reviewers. Of these 312 studies, a previously undetected lesion was identified in only 6 cases (1.9%) based on changes observed on postcontrast sequences. Final diagnoses included meningoencephalitis of unknown origin (n = 1), feline infectious peritonitis (n = 1), and neoplasia (n = 2). All 4 of these cases had persistent neurological deficits suggestive of an underlying brain lesion. Contrast enhancement observed in the 2 other cases was considered falsely positive based on the results of further investigations.Conclusions and Clinical ImportanceIn patients with normal neurological examination and normal precontrast MRI, the subsequent administration of IV gadolinium‐based contrast media is highly unlikely to disclose a previously unidentified lesion, calling into question the routine administration of contrast media to these patients. However, administration still should be considered in animals with persistent neurological deficits suggestive of an underlying inflammatory or neoplastic brain lesion.

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Section: Discussionmentioning

confidence: 99%

“…The findings observed on postcontrast sequences may assist in the further characterization of a brain lesion observed on precontrast sequences 3, 4, 5. However, the routine administration of gadolinium‐based contrast media has been questioned for human patients, especially if no lesion is observed on precontrast sequences 6.…”

mentioning

confidence: 99%

Exclusion of a Brain Lesion: Is Intravenous Contrast Administration Required after Normal Precontrast Magnetic Resonance Imaging?

Ives

Rousset

Heliczer

et al. 2014

Veterinary Internal Medicne

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“…Although many investigators have attempted to utilize a variety of imaging techniques to diagnose, and even grade, intracranial lesions in dogs, specificity, sensitivity, or both have been shown to be consistently suboptimal in numerous studies,12, 15, 16, 36, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56 particularly when applied to clinically relevant prospective random populations of patients. A majority of intracranial tumors in both dogs and cats are hypo‐ to isointense on T1‐weighted imaging, and hyperintense on T2‐weighted imaging.…”

Section: Imagingmentioning

confidence: 99%

“…A majority of intracranial tumors in both dogs and cats are hypo‐ to isointense on T1‐weighted imaging, and hyperintense on T2‐weighted imaging. The majority are also contrast enhancing after administration of gadolinium‐based contrast agents 12, 15, 16, 21, 54, 55. A variety of tumor “specific” findings relating to MRI have been reported variably in several studies, some of which are listed below.…”

Section: Imagingmentioning

confidence: 99%

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Dickinson

2014

Veterinary Internal Medicne

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Intracranial neoplasia is a common clinical condition in domestic companion animals, particularly in dogs. Application of advances in standard diagnostic and therapeutic modalities together with a broad interest in the development of novel translational therapeutic strategies in dogs has resulted in clinically relevant improvements in outcome for many canine patients. This review highlights the status of current diagnostic and therapeutic approaches to intracranial neoplasia and areas of novel treatment currently in development.

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“…[17][18][19][20][21] According to most recent studies, the Magnetic Resonance Imaging (MRI) criteria for presumptive diagnosis of meningioma were: the occurrence of a single solid broad dural based extra-axial mass with distinct margins and the presence of intense and uniform enhancement with a dural tail sign.…”

mentioning

confidence: 99%

Stereotactic Volume Modulated Arc Radiotherapy Protocol for Canine Intracranial Meningioma.

Dolera¹,

Malfassi²,

Carrara³

et al. 2017

IJAR

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Objective: to assess High Dose Hypofractionated Volume Modulated Arc Radiotherapy (HDH-VMAT) feasibility and clinical efficacy in canine meningiomas. Design: a prospective study was conducted on thirty-three patients with a presumptive diagnosis of encephalic meningiomas assumed from Magnetic Resonance Imaging (MRI) findings. Methods: all dogs, whose neurological status was scored through the use of an innovative evaluation scale (Romanengo Veterinary Neurological Scale -RVNS), received HDH-VMAT by a Linear Accelerator (LINAC) equipped with an external beam modulator micro-multileaf collimator and an XVI Cone Beam Computed Tomography system (CBCT). The prescribed mean dose was 33 Gy delivered in 5 fractions. The treatment feasibility was tested through planned and delivered dose agreement checks. Regular clinical examinations were performed during and after irradiation time with regard to mentation, deambulation, cranial nerve dysfunction and seizures. Serial MRI exams were done 60 days after irradiation and after 4, 6, 12, 18, 24 months. Volumetric disease reduction criteria implemented with clinical neurological systematic evaluation were adopted to assess the course and to categorize patients' response. Results: complete and partial responses were observed on the whole in 65,5% of alive patients 24 months after irradiation. Two-year overall and disease-specific survival rates were 74.3% and 97.4%, respectively, and the putative radiotoxic effects were found to be few and slight. Conclusions: HDH-VMAT is a valid therapeutic option for encephalic canine meningioma. Volumetric MRI evaluation together with the hereby proposed RVNS should be considered for the evaluation of the post-treatment response.Copy Right, IJAR, 2017,. All rights reserved.

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Magnetic resonance imaging findings in 40 dogs with histologically confirmed intracranial tumours

Cited by 100 publications

References 11 publications

Exclusion of a Brain Lesion: Is Intravenous Contrast Administration Required after Normal Precontrast Magnetic Resonance Imaging?

Exclusion of a Brain Lesion: Is Intravenous Contrast Administration Required after Normal Precontrast Magnetic Resonance Imaging?

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

Stereotactic Volume Modulated Arc Radiotherapy Protocol for Canine Intracranial Meningioma.

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