Magnetic Resonance Imaging Features of Tumors of the Spine and Spinal Cord in Dogs

Kippenes, Hege; Gavin, Patrick R.; Bagley, Rodney S.; Silver, Gena M.; Tucker, Russell L.; Sande, Ronald D.

doi:10.1111/j.1740-8261.1999.tb00890.x

Cited by 94 publications

(134 citation statements)

References 11 publications

(2 reference statements)

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“…However, a malignant canine peripheral nerve sheath tumor has been reported, of which T1-weighted imaging showed isointensity compared to the surrounding muscles, and T2-weighted imaging showed hyperintensity. The tumor was unevenly enhanced by Gd-DTPAenhanced T1-weighted imaging [7]. Similar MRI findings in a malignant canine peripheral nerve sheath tumor in the mid-diaphysis of the left humerus have been reported [13].…”

Section: )supporting

confidence: 77%

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Okada

Kitagawa

Shibuya

et al. 2007

The Journal of Veterinary Medical Science

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Comprehensive Veterinary Clinical Studies,4) Veterinary Pathology, 5) Veterinary Physiology and 6) Preventive Veterinary Medicine and Animal Health, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan (Received 17 August 2006/Accepted 22 February 2007 ABSTRACT. A 10-year-old female mongrel cat with back pain was brought to the Nihon University Animal Medical Center. Palpation demonstrated a mass in the back region. Radiography revealed partial destruction of the processus spinosus and the arch of the T8 and T9 vertebrae. On magnetic resonance imaging, the mass was found to have compressed the spinal cord and extended to the outside of the spinal canal. We performed extirpation of the mass, and confirmed that it arose from the spinal canal. Histopathologically, the mass was a malignant peripheral nerve sheath tumor. KEY WORDS: feline, malignant peripheral nerve sheath tumor, MRI.J. Vet. Med. Sci. 69(6): 683-686, 2007 There is considerable confusion concerning the nomenclature of tumors deriving from the peripheral nerve sheath. Histologically, such tumors are classified into categories of benign peripheral nerve sheath tumors (schwannoma and neurofibroma) and malignant peripheral nerve sheath tumors (malignant schwannoma and neurofibrosarcoma) [8].There have been relatively few studies on feline peripheral nerve sheath tumors arising from the spinal canal, and malignant cases of this tumor are even rarer [1,8,9,19]. We encountered a cat with a malignant peripheral nerve sheath tumor arising from the spinal canal. We evaluated the clinical signs, radiography and magnetic resonance imaging (MRI) findings, surgery, and postoperative course.A 10-year-old female mongrel cat, weighing 2.14 kg, with back pain was brought to the Nihon University Animal Medical Center. The cat had been unhealthy with anorexia and constipation for 1 month, and was taken to a local veterinarian. The cat had suffered from back pain for 1 week. A mass was detected in the region of the back, and the cat was referred to our hospital for diagnosis and treatment.On initial examination, the body temperature was 40.3°C, and the heart and respiratory rates were 212/min and 40/ min, respectively. Hematological examination demonstrated slight increases in liver enzyme levels (alanine aminotransferase, 156 U/L; aspartate aminotransferase, 116 U/ L). Neurologically, the cat could walk, and all postural reactions were within the normal ranges. Spinal reflexes and deep pain were normal in both the thoracic and pelvic limbs. The cranial nerves were normal. Radiography revealed partial destruction of the T8 vertebral processus spinosus on the caudal side, T9 vertebral processus spinosus on the cranial side and T9 vertebral arch, between which hyperlucency was observed (Fig. 1).MRI (FlexArt, Toshiba, Tokyo, 1.5T) demonstrated a mass, measuring about 2.5-3 cm, on the back of the T8-9 vertebrae. T1-weighted imaging (TR=500 msec, TE=15 msec, FA 90°, NAQ 1) of the mas...

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Section: )supporting

confidence: 77%

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Okada

Kitagawa

Shibuya

et al. 2007

The Journal of Veterinary Medical Science

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“…A malignant peripheral nerve sheath tumor reported in a cat showed iso-intensity compared to the spinal cord on T1WI, a mixture of hypo-, iso-, and hyper-intensities on T2WI, and it was unevenly enhanced on Gd-DTPA-enhanced T1WI [17]. Spinal osteosarcoma in dogs reportedly shows iso-or hypo-intensity on T1WI, iso-intensity on T2WI, and non-uniform enhancement with contrast medium, which differs from the present case [10]. In the present cat, the osteosarcoma showed isointensity on T1WI and hypo-intensity on T2WI.…”

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confidence: 55%

“…On the other hand, MRI has been found to be valuable in evaluating lesion location and volume, revealing tumor extent, defining its relationship with the vertebral canal, and showing tissue specificity [7,21]. Moreover, a detailed differential diagnosis can be performed based on the MRI signal [10]. It has been suggested that early diagnosis of vertebral tumors (primary and metastatic) may improve survival [6].…”

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confidence: 99%

Magnetic Resonance Imaging and Computed Tomography Findings of Vertebral Osteosarcoma in a Cat

Okada

Kitagawa

Nagasawa

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. An 8-year-old female Persian cat with a gait disorder was brought to our hospital. Pelvic limb mobility had gradually reduced over the preceding 3 months, then rapidly deteriorated 2 weeks before consultation. Signs also occurred in the thoracic limbs. With a tentative diagnosis of neural disease, magnetic resonance imaging and computed tomography were performed. T1-weighted imaging showed isointensity in the seventh cervical vertebra, while T2-weighted imaging revealed hypointensity. Contrast-enhanced T1-weighted imaging revealed a uniformly enhancing mass. Extirpation of the mass relieved the clinical signs, leading to disappearance of the neurological signs. The histopathological examination suggested osteosarcoma. The diagnosis of spinal tumors is more difficult than that of tumors of the appendicular skeleton, because the radiographic diagnosis is difficult, and various diseases are suspected from the neurological signs. Radiologic evaluation of human patients who present with osseous vertebral lesions often includes radiography, computed tomography (CT), and magnetic resonance imaging (MRI). Because of the complex anatomy of the vertebrae, CT is more useful than conventional radiography for evaluating lesion location and analyzing bone destruction and condensation [18]. On the other hand, MRI has been found to be valuable in evaluating lesion location and volume, revealing tumor extent, defining its relationship with the vertebral canal, and showing tissue specificity [7,21]. Moreover, a detailed differential diagnosis can be performed based on the MRI signal [10]. It has been suggested that early diagnosis of vertebral tumors (primary and metastatic) may improve survival [6].Tumors rarely invade cat bones, with an estimated bone tumor incidence of 4.9/100,000 cats [5,8]. Osteosarcoma accounts for approximately 70-80% of malignant primary bone tumors in cats, and it less frequently involves the axial skeleton than the appendicular skeleton [4,8]. Only a few studies have reported vertebral osteosarcoma [11,13,16]. Few studies have reported MRI and CT findings for vertebral osteosarcoma, and more detailed data have not been reported [13].We report herein the case of a cat with cervical vertebral osteosarcoma involving the epidural area and compressing the spinal cord. Surgery was performed after MRI and CT. In the present case, the postoperative course was good. To the best of our knowledge, the detailed findings of MRI or CT for vertebral osteosarcoma in cats have not been published. The clinical signs, imaging findings, and postoperative course for this case are presented.An 8-year-old, neutered female Persian cat weighing 2.9 kg was brought to our hospital with a gait disorder. Ataxia of the pelvic limbs had developed and gradually deteriorated over the preceding 3 months. Signs had also been observed in the thoracic limbs, with rapid deterioration over the previous 2 weeks. On consultation, the cat's general condition was good. However, the right thoracic limb showed inversion. Hematological da...

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“…However, we did not observe the previously described psammoma bodies in the centre of the spirals. Meningiomas generally show intradural-extramedullary localisation (Kippenes et al 1999). It has been reported that, in dogs, a large percentage of meningiomas develop intracranially (Summers et al 1995) and less frequently in the spinal cord (Montoliu et al 2006).…”

Section: Discussionmentioning

confidence: 99%

Intramedullary spinal cord meningioma in a Boxer: a case report

et al. 2015

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Meningiomas are the most common primary tumours of the canine central nervous system. The incidence of these tumours increases with age and they are more frequently encountered in dogs older than seven years. Meningiomas are solitary, well-defined neoplasias that more commonly grow via compression and less commonly by infiltrating the nervous tissue. Meningiomas exhibit 82% intracranial, 15% intraspinal and 3% retrobulbar location. Meningiomas of the spinal cord are mostly benign in character with intradural-extramedullary location in the cervical segments. The case reported here consisted of a 10-year old male Boxer presenting with a complaint of inability to use its left foreleg. In the neurological examination, upper motor neuron findings were recorded and direct radiography, myelography and magnetic resonance imaging (MRI) of the cervical region were performed. Interpretation of the transversal, coronal and sagittal cross-section magnetic resonance images taken of T1-weighted, T2-weighted and T1-weighted with contrast sequences, revealed a well-defined intramedullary mass at the level of the C5-C6 vertebra. Histopathological examination of the neoplastic mass revealed it to be a transitional (mixed) meningioma which had infiltrated into the spinal cord.

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Magnetic Resonance Imaging Features of Tumors of the Spine and Spinal Cord in Dogs

Cited by 94 publications

References 11 publications

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Malignant Peripheral Nerve Sheath Tumor arising from the Spinal Canal in a Cat

Magnetic Resonance Imaging and Computed Tomography Findings of Vertebral Osteosarcoma in a Cat

Intramedullary spinal cord meningioma in a Boxer: a case report

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