Magnetic resonance imaging features in 283 patients with primary biliary cholangitis

İdilman, İlkay S.; Venkatesh, Sandeep; Eaton, John E.; Bolan, Candice W.; Osman, Karim; Maselli, Daniel B.; Menias, Christine O.; Venkatesh, Sudhakar K.

doi:10.1007/s00330-020-06855-0

Cited by 22 publications

(23 citation statements)

References 21 publications

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“…We identified radiologic hepatomegaly in 9.3%, 8.4% and 10.1%, of patients who had abdominal US, CT, and MRI respectively. These findings are similar to what has been previously reported in other studies showing hepatomegaly in PBC patients with a prevalence ranging 11-19% 9,10 , and 37.8-56.5% 11,17,19 , for CT, and MRI respectively. Variations in hepatomegaly findings have been attributed to severity of disease with larger liver size associated with early disease.…”

Section: Discussionsupporting

confidence: 92%

“…Lymphadenopathy can be a non-specific finding in infectious, inflammatory and malignant hepatic diseases 10,11,19 . Prominent or enlarged lymph nodes should always prompt a thorough malignancy workup, before being attributed to underlying PBC.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the periportal "halo sign" on T1-and T2-weighted MRI, characterized by rounded low signal-intensity abnormality around portal venous branches, has been identified as a specific finding in advanced PBC 3,11,[16][17][18] . The prevalence of the halo sign has ranged from 27.6% to 75.8%, depending on the severity of disease in the cohorts analyzed.…”

Section: Discussionmentioning

confidence: 99%

“…Sequelae of portal hypertension were less prevalent in our cohort than previously reported 9,10,18,19 . Prior MRI studies have reported a prevalence of varices between 7.8-15.3%, splenomegaly between 20.1-86.4%, and ascites between 5.7-47.7% 11,16,22 . Portal hypertension is generally seen in more advanced disease and the wide range of distribution of these findings could be attributed to inherent differences in disease severity among the different patient cohorts.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of computed tomography (CT) images in PBC have long shown a tendency for earlier development of sequelae of portal hypertension than would be expected for the macroscopic degree of hepatic fibrosis 9,10 , although they are insufficiently specific to make a definitive diagnosis. However, it has been suggested that some of these features are useful in predicting advanced fibrosis 11 , and thus may obviate the need for biopsy.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and Imaging Features of Primary Biliary Cholangitis

Xie¹,

Nyabanga²,

Sehmbhi³

et al. 2022

Preprint

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Abstract/KeywordsBackground and AimsPrimary biliary cholangitis (PBC) is a chronic inflammatory autoimmune disease of the biliary epithelial cells, causing slow progression of cholestasis and fibrosis. The aim of the study is to summarize the imaging features of PBC and examine the correlation between its clinicopathological and radiologic features, elucidating the specific clinicopathological and radiologic differences between male and female PBC patients, as well as between AMA-positive and AMA-negative PBC patients.MethodsDemographic, laboratory, radiologic and survival data were collected retrospectively for patients diagnosed and treated for PBC at the Mount Sinai Health System between 2016 and 2020 with at least one ultrasound, CT, or MRI of abdomen available for assessment. Biochemical and radiologic data were compared between male v.s. female groups, and AMA-positive v.s. AMA-negative group.ResultsA total of 273 patients diagnosed with PBC were included. Non-specific hepatic parenchymal disease, cirrhosis, cholelithiasis, splenomegaly, lymphadenopathy, benign liver masses/cysts were the most common features on abdominal images. 24% of PBC patients had biliary tree abnormalities on MRI. LAD was reported in 38-47% of PBC patients. There was no significant difference in age, race, or ethnicity between the sexes of patients with PBC, however imaging characteristics of portal hypertension were more frequently seen in men. AMA-negative PBC patients had similar distributions of age, race/ethnicity and survival to AMA-positive PBC patients.ConclusionOur study summarized the clinicopathological and imaging features of PBC and distinct subgroups. This would assist in the diagnosis of PBC and avoid over-testing in real-world practice.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathological and Imaging Features of Primary Biliary Cholangitis

Xie¹,

Nyabanga²,

Sehmbhi³

et al. 2022

Preprint

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Primary biliary cholangitis: review for radiologists

Morgan

Sundaram

2021

Abdom Radiol

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Acquired ductopenia: an insight into imaging findings

Khot,

Shelman,

Ludwig

et al. 2024

Abdom Radiol

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Hepatic ductopenia is a pathologic diagnosis characterized by a decrease in the number of intrahepatic bile ducts as a consequence of various underlying etiologies. Some etiologies, such as primary sclerosing cholangitis, primary biliary cholangitis, and ischemic cholangitis, often have distinctive imaging findings. In contrast, other causes such as chronic rejection following liver transplantation, drug-induced biliary injury, infection, malignancy such as lymphoma, and graft-versus-host disease may only have ancillary or non-specific imaging findings. Thus, diagnosing ductopenia in conditions with nonspecific imaging findings requires a multidimensional approach, including clinical evaluation, serological testing, imaging, and liver histology to identify the underlying cause. These etiologies lead to impaired bile flow, resulting in cholestasis, liver dysfunction, and, ultimately, cirrhosis and liver failure if the underlying cause remains untreated or undetected. In the majority of instances, individuals diagnosed with ductopenia exhibit a positive response to treatment addressing the root cause or cessation of the causative agent. This article focuses on acquired causes of ductopenia, its clinical manifestation, histopathology, imaging diagnosis, and management. Graphical abstract

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Magnetic resonance imaging features in 283 patients with primary biliary cholangitis

Cited by 22 publications

References 21 publications

Clinicopathological and Imaging Features of Primary Biliary Cholangitis

Clinicopathological and Imaging Features of Primary Biliary Cholangitis

Primary biliary cholangitis: review for radiologists

Acquired ductopenia: an insight into imaging findings

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