Magnetic resonance imaging-based measurement of internal deformation of vibrating vocal fold models

Abstract

A method is presented for tracking the internal deformation of self-oscillating vocal fold models using magnetic resonance imaging (MRI). Silicone models scaled to four times life-size to lower the flow-induced vibration frequency were embedded with fiducial markers in a coronal plane. Candidate marker materials were tested using static specimens, and two materials, cupric sulfate and glass, were chosen for testing in the vibrating vocal fold models. The vibrating models were imaged using a gated MRI protocol wherein MRI acquisition was triggered using the subglottal pressure signal. Two-dimensional image slices at different phases during self-oscillation were captured, and in each phase the fiducial markers were clearly visible. The process was also demonstrated using a three-dimensional scan at two phases. The benefit of averaging to increase signal-tonoise ratio was explored. The results demonstrate the ability to use MRI to acquire quantitative deformation data that could be used, for example, to validate computational models of flowinduced vocal fold vibration and quantify deformation fields encountered by cells in bioreactor studies. V

3D-FV-FE Aeroacoustic Larynx Model for Investigation of Functional Based Voice Disorders

“…Pickup and Thomson ( 2009 ) and Zhang et al ( 2012 ) investigated asymmetric vocal fold oscillations with a silicone model. Such models can mimic specific physiological and disordered motion patterns of the vocal folds for which they have been developed for and are therefore well-established in voice science (Zhang et al, 2004 ; Thomson et al, 2005 ; Park and Mongeau, 2008 ; Kirmse et al, 2010 ; Murray and Thomson, 2012 ; Kniesburges et al, 2013 , 2016 ; Van Hirtum and Pelorson, 2017 ; Motie-Shirazi et al, 2019 ; Taylor et al, 2019 ; Romero et al, 2020 ). However, both ex vivo and synthetic larynx models are restricted regarding the spatial resolution of the measuring data of fluid flow, the vocal fold dynamics, and their interaction.…”

Imaging the Vocal Folds: A Feasibility Study on Strain Imaging and Elastography of Porcine Vocal Folds

“…Furthermore, the vocal tract [65,66] and artificial VFs [67] have been examined with MRI. The tissue needs to be excited by an internal or external source [64].…”