Magnetic Resonance Imaging–Based Grading of Cartilaginous Bone Tumors

Fritz, Benjamin; Müller, Daniel; Sutter, Reto; Wurnig, Moritz C.; Wagner, Matthias; Pfirrmann, Christian W. A.; Fischer, Michael A.

doi:10.1097/rli.0000000000000486

Cited by 57 publications

(45 citation statements)

References 57 publications

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“…Die Tumorheterogenität ist bekanntermaßen mit einer ungünstigen Tumorbiologie assoziiert [39,40]. Möglicherweise können MRT-Texturanalysen der Tumorheterogenität zwischen Enchondromen und niedrigmalignen Chondrosarkomen differenzieren [44,45]. Durch eine Kombination von Texturanalyse und MRT-Bildkriterien kann eine Genauigkeit der Differenzierung zwischen benignen und niedrigmalignen chondrogenen Tumoren von 91,2 % erreicht werden [45].…”

Section: Differenzierung Zwischen Enchondrom Und Act/chondrosarkomunclassified

“…Möglicherweise können MRT-Texturanalysen der Tumorheterogenität zwischen Enchondromen und niedrigmalignen Chondrosarkomen differenzieren [44,45]. Durch eine Kombination von Texturanalyse und MRT-Bildkriterien kann eine Genauigkeit der Differenzierung zwischen benignen und niedrigmalignen chondrogenen Tumoren von 91,2 % erreicht werden [45]. Da in den Studien unterschiedliche prädiktive Texturparameter identifiziert wurden, ist davon auszugehen, dass weitere Untersuchungen notwendig sind, um diese vielversprechenden Ergebnisse zu validieren.…”

Section: Differenzierung Zwischen Enchondrom Und Act/chondrosarkomunclassified

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Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

Rofo

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Background Chondrogenic tumors are the most frequent primary bone tumors. Malignant chondrogenic tumors represent about one quarter of malignant bone tumors. Benign chondrogenic bone tumors are frequent incidental findings at imaging. Radiological parameters may be helpful for identification, characterization, and differential diagnosis. Methods Systematic PubMed literature research. Identification and review of studies analyzing and describing imaging characteristics of chondrogenic bone tumors. Results and conclusions The 2020 World Health Organization (WHO) classification system differentiates between benign, intermediate (locally aggressive or rarely metastasizing), and malignant chondrogenic tumors. On imaging, typical findings of differentiated chondrogenic tumors are lobulated patterns with a high signal on T2-weighted magnetic resonance imaging (MRI) and ring- and arc-like calcifications on conventional radiography and computed tomography (CT). Depending on the entity, the prevalence of this chondrogenic pattern differs. While high grade tumors may be identified due to aggressive imaging patterns, the differentiation between benign and intermediate grade chondrogenic tumors is challenging, even in an interdisciplinary approach. Key Points: Citation Format

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Section: Differenzierung Zwischen Enchondrom Und Act/chondrosarkomunclassified

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Engel

Herget

Füllgraf

et al. 2020

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“…To reduce bias we excluded tumors other than primary central chondrosarcoma from our systematic review. Several studies were excluded as they included, e.g., secondary or periosteal chondrosarcoma as well and we were not able to extract data on the primary central chondrosarcoma (Varma et al 1992, Geirnaerdt et al 1993, De Beuckeleer et al 1995, Geirnaerdt et al 2000, Fritz et al 2018. Excluding studies to reduce bias resulted in a limited number of tumors being included in this systematic review.…”

Section: Limitationsmentioning

confidence: 99%

Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review

et al. 2020

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Background and purpose — Adequate staging of chondroid tumors at diagnosis is important as it determines both treatment and outcome. This systematic review provides an overview of MRI criteria used to differentiate between atypical cartilaginous tumors (ACT) and high-grade chondrosarcoma (HGCS). Patients and methods — For this systematic review PubMed and Embase were searched, from inception of the databases to July 12, 2018. All original articles describing MRI characteristics of pathologically proven primary central chondrosarcoma and ACT were included. A quality appraisal of the included papers was performed. Data on MRI characteristics and histological grade were extracted by 2 reviewers. Meta-analysis was performed if possible. The study is registered with PROSPERO, CRD42018067959. Results — Our search identified 2,132 unique records, of which 14 studies were included. 239 ACT and 140 HGCS were identified. The quality assessment showed great variability in consensus criteria used for both pathologic and radiologic diagnosis. Due to substantial heterogeneity we refrained from pooling the results in a meta-analysis and reported non-statistical syntheses. Loss of entrapped fatty marrow, cortical breakthrough, and extraosseous soft tissue expansion appeared to be present more often in HGCS compared with ACT. Interpretation — This systematic review provides an overview of MRI characteristics used to differentiate between ACT and HGCS. Future studies are needed to develop and assess more reliable imaging methods and/or features to differentiate ACT from HGCS.

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“…Effective treatment by an antiangiogenic drug causes histogram changes of K trans from a broad and heterogeneous distribution to a narrow shape . The utility of histogram analysis for osseous tumors has not been well studied, but one very recent study used texture analysis for cartilaginous bone tumors . Texture analysis identifies not only gray‐level frequency distribution but also pixel location and relationship to adjacent pixels, such as gray‐level co‐occurrence matrix or run‐length matrix .…”

Section: Histogram Analysis/texture Analysismentioning

confidence: 99%

“…106 The utility of histogram analysis for osseous tumors has not been well studied, but one very recent study used texture analysis for cartilaginous bone tumors. 108 Texture analysis identifies not only gray-level frequency distribution but also pixel location and relationship to adjacent pixels, such as gray-level co-occurrence matrix or run-length matrix. 109 They showed better interreader agreement in texture analysis than morphological MRI analysis, and better diagnostic accuracies in texture analysis for differentiating benign from malignant, as well as benign from low-grade cartilaginous lesions compared with morphological analysis.…”

Section: Histogram Analysis/texture Analysismentioning

confidence: 99%

MRI biomarkers in osseous tumors

Fukuda

Wengler

Carvalho

et al. 2019

Magnetic Resonance Imaging

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Although radiography continues to play a critical role in osseous tumor assessment, there have been remarkable advances in cross‐sectional imaging. MRI has taken a lead in this assessment due to high tissue contrast and spatial resolution, which are well suited for bone lesion assessment. More recently, although somewhat lagging other organ systems, quantitative parameters have shown promising potential as biomarkers for osseous tumors. Among these sequences are chemical shift imaging (CSI), apparent diffusion coefficient (ADC), and intravoxel incoherent motion (IVIM) from diffusion‐weighted imaging (DWI), quantitative dynamic contrast enhanced (DCE)‐MRI, and magnetic resonance spectroscopy (MRS). In this article, we review the background and recent roles of these quantitative MRI biomarkers for osseous tumors. Level of Evidence: 3 Technical Efficacy Stage: 3 J. MAGN. RESON. IMAGING 2019. J. Magn. Reson. Imaging 2019;50:702–718.

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Magnetic Resonance Imaging–Based Grading of Cartilaginous Bone Tumors

Abstract: Texture analysis improves diagnostic accuracy for differentiation of benign and malignant as well as for benign and low-grade cartilaginous lesions when compared with morphologic MRI analysis.

Cited by 57 publications

References 57 publications

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Chondrogenic Bone Tumors: The Importance of Imaging Characteristics

Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review

MRI biomarkers in osseous tumors

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