“…Several MRI abnormalities have been described in WD; on T2-weighted images, WD is suggested by atrophy, putaminal lesions with a pattern of bilateral concentric-laminar T2 hyperintensity, and involvement of the pars compacta of the substantia nigra (SN), periacqueductal gray matter, pontine tegmentum, and thalamus. 3,4 Nevertheless, today's modern ultrasound systems allow highresolution B-mode imaging of brain parenchyma, and in the clinical workup, the use of TCS for early recognition and differential diagnosis of neurodegenerative disorders is promising. 8 In a recent study on 21 patients affected by WD with or without neurologic symptoms, TCS revealed LN hyperechogenicity in all symptomatic patients and in 2 of 3 asymptomatic patients.…”