Magnetic Resonance Imaging and Positron Emission Tomography Approaches to Imaging Vascular and Cardiac Inflammation

Amsallem, Myriam; Saito, Toshinobu; Tada, Yuko; Dash, Rajesh; McConnell, Michael V.

doi:10.1253/circj.cj-16-0224

Cited by 12 publications

(4 citation statements)

References 83 publications

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“…The intricate pathophysiology of atherosclerotic plaques contributes to low target abundance and dynamic expression, necessitating specificity, sensitivity, radiotracer pharmacokinetics, and appropriate imaging protocols for optimal detection. PET has been preferred among imaging modalities for its high sensitivity, quantitative capabilities, non-invasiveness, and established translational pathways [68,69]. Atherosclerosis development encompasses multiple stages, each featuring unique biomarkers detectable through imaging, providing crucial insights into disease progress and status [70].…”

Section: Radiopharmaceuticals In Atherosclerosis Imagingmentioning

confidence: 99%

Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives

Rehman,

Nadeem,

Akram

et al. 2024

Biomedicines

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Ischemic stroke poses a significant global health challenge, necessitating ongoing exploration of its pathophysiology and treatment strategies. This comprehensive review integrates various aspects of ischemic stroke research, emphasizing crucial mechanisms, therapeutic approaches, and the role of clinical imaging in disease management. It discusses the multifaceted role of Netrin-1, highlighting its potential in promoting neurovascular repair and mitigating post-stroke neurological decline. It also examines the impact of blood–brain barrier permeability on stroke outcomes and explores alternative therapeutic targets such as statins and sphingosine-1-phosphate signaling. Neurocardiology investigations underscore the contribution of cardiac factors to post-stroke mortality, emphasizing the importance of understanding the brain–heart axis for targeted interventions. Additionally, the review advocates for early reperfusion and neuroprotective agents to counter-time-dependent excitotoxicity and inflammation, aiming to preserve tissue viability. Advanced imaging techniques, including DWI, PI, and MR angiography, are discussed for their role in evaluating ischemic penumbra evolution and guiding therapeutic decisions. By integrating molecular insights with imaging modalities, this interdisciplinary approach enhances our understanding of ischemic stroke and offers promising avenues for future research and clinical interventions to improve patient outcomes.

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Section: Radiopharmaceuticals In Atherosclerosis Imagingmentioning

confidence: 99%

Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives

Rehman,

Nadeem,

Akram

et al. 2024

Biomedicines

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“…Positron emission tomography (PET) is another emerging imaging tool with the potential to provide complementary information about the inflammatory process in the myocardium [64,65]. Several tracers have been tested to detect enhanced myocardial metabolism and thus underlying inflammation [66].…”

Section: Nuclear Medicinementioning

confidence: 99%

Personalized Management of Myocarditis and Inflammatory Cardiomyopathy in Clinical Practice

Tymińska

Ozierański

Skwarek

et al. 2022

JPM

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Myocarditis is an inflammatory heart disease induced by infectious and non-infectious causes frequently triggering immune-mediated pathologic mechanisms leading to myocardial damage and dysfunction. In approximately half of the patients, acute myocarditis resolves spontaneously while in the remaining cases, it may evolve into serious complications including inflammatory cardiomyopathy, arrhythmias, death, or heart transplantation. Due to the large variability in clinical presentation, unpredictable course of the disease, and lack of established causative treatment, myocarditis represents a challenging diagnosis in modern cardiology. Moreover, an increase in the incidence of myocarditis and inflammatory cardiomyopathy has been observed in recent years. However, there is a growing potential of available non-invasive diagnostic methods (biomarkers, serum anti-heart autoantibodies (AHA), microRNAs, speckle tracking echocardiography, cardiac magnetic resonance T1 and T2 tissue mapping, positron emission tomography), which may refine the diagnostic workup and/or noninvasive follow-up. Personalized management should include the use of endomyocardial biopsy and AHA, which may allow the etiopathogenetic subsets of myocarditis (infectious, non-infectious, and/or immune-mediated) to be distinguished and implementation of disease-specific therapies. In this review, we summarize current knowledge on myocarditis and inflammatory cardiomyopathy, and outline some practical diagnostic, therapeutic, and follow-up algorithms to facilitate comprehensive individualized management of these patients.

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“…Finally, angiogenesis and apoptosis are additional promising targets for detection of maladaptive RV in PH (87). While these processes have been imaged in LV diseases (88) and PH animal models, their clinical application in PAH is still pending.…”

Section: Molecular Imaging a Deeper View Into The Biology Of The Rigmentioning

confidence: 99%

Right heart imaging in patients with heart failure

Amsallem

Kuznetsova

Hanneman

et al. 2016

Current Opinion in Cardiology

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Purpose of review To describe the recent advances made in imaging of the right heart, including deformation imaging, tissue and flow characterization by resonance imaging (MRI), and molecular imaging. Recent findings Recent developments have been made in the field of deformation imaging of the right heart, which may improve risk stratification of patients with heart failure and pulmonary hypertension. In addition, more attention has been given to load adaptability metrics of the right heart; these simplified indices however still face challenges from a conceptual point of view. The emergence of novel MRI sequences, such as native T1 mapping, allows better detection and quantification of myocardial fibrosis and could allow better prediction of post-surgical recovery of the right heart. Other advances in MRI include four-dimensional flow imaging, which may be particularly useful in congenital heart disease or for the detection of early stages of pulmonary vascular disease. Summary This review will place the recent developments in right heart imaging in the context of clinical care and research.

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Magnetic Resonance Imaging and Positron Emission Tomography Approaches to Imaging Vascular and Cardiac Inflammation

Cited by 12 publications

References 83 publications

Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives

Molecular Mechanisms of Ischemic Stroke: A Review Integrating Clinical Imaging and Therapeutic Perspectives

Personalized Management of Myocarditis and Inflammatory Cardiomyopathy in Clinical Practice

Right heart imaging in patients with heart failure

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