“…Recent years have witnessed a rapid and continuous evolution in the diagnosis of biliary obstructive disease. Totraditional methodologies, such as US (ultrasonography) ,)CT (computed tomography), ERCP (endoscopic retrograde cholangiopancreatography) and PTC (percutaneous transhepatic cholangiography), there have been added MRCP (magnetic resonance cholagiopancreatography) and CCTcholangio computed tomography), which have prompted a comprehensive review of the whole diagnostic imaging procedure [5][6][7][8][9][10][11][12] .Ultrasound has been always considered the first choice technique in the study of biliary obstructive disease, due to its accessibility, speed, ease of performance and low cost [13,14] . Thishas been even more so in recent years, following the technological evolution of US equipment which, thanks to Tissue Harmonic Imaging (THI), gives better visualization of fluid-filled structures (such as the biliary structures), reduced artifacts, and enhanced contrast resolution [15,16] .ERCP has been considered the gold standard of biliary structureimaging since its introduction in 1970, and is currentlymaintaining its therapeutic application.…”