Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Siedek, Florian; Yeo, Sin Yuin; Heijman, Edwin; Grinstein, Olga; Bratke, Grischa; Heneweer, Carola; Puesken, Michael; Persigehl, Thorsten; Maintz, David; Grüll, Holger

doi:10.1055/a-0817-5686

Cited by 20 publications

(13 citation statements)

References 49 publications

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“…The temperature feedback allows the direct delivery of a defined dose of thermal ablation to the malignant tissue. Nowadays, new transducers are developed to provide the treatment in several malignancies, including prostate or breast cancers [72]. Other indications of MRgFUS/MR-HIFU use might include the palliation of pain due to tumour occurrence or metastasis by producing tissue denervation, tumour mass reduction and neuromodulation [73].…”

Section: Focused Ultrasound As a Fertility-sparing Methods In Oncology?mentioning

confidence: 99%

The role of magnetic resonance-guided focused ultrasound in fertility sparing treatment of uterine fibroids—current perspectives

Ciebiera¹,

Łoziński²

2020

ecancer

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Uterine fibroids (UFs) are the most common benign tumours of the female reproductive system and the most frequent reason for hysterectomy worldwide. UFs are reported in 20%-70% of women of reproductive age depending on a study group. Although most women with UFs are asymptomatic, over 30% of them will present with different symptoms. Abnormal uterine bleeding, pain, pressure and infertility are the most common. Lesions that cause these kinds of symptoms may require medical intervention.Trends in UF treatment change along with patient awareness and the introduction of new methods and techniques. Selecting an appropriate treatment option should be individualised and adjusted to the patient's expectations as much as possible. This choice will mostly depend on the patient's age, UF location, the size and number of lesions, severity of symptoms and, most importantly, the patient's expectations concerning the preservation of fertility. Observations made for the past few years showed an increasing number of pre-and perimenopausal women who wish to preserve their uterus or decline surgery. In line with current trends and demands in medicine, great importance is attached to the development and upgrade of new minimally invasive or noninvasive procedures in UF therapy.Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) is not associated with severe destruction of the uterine cavity and walls. For this reason, this method may be considered as a kind of hope in fertility-sparing UF therapy and the data about its use in this indication raises future hope. In this review, we summarise the available data on the use of MR-HIFU as a fertility-sparing method in the treatment of UFs. We also indicate how it could evolve in the future.According to the available data, MR-HIFU is a relatively safe noninvasive method which seems not to deteriorate fertility compared to the pre-treatment status. MR-HIFU may constitute an alternative solution and be chosen in patients who meet the qualification criteria and deny other methods, which also facilitates the use of other treatment options in case the procedure is ineffective. Further randomised studies are necessary to confirm the above information.

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Section: Focused Ultrasound As a Fertility-sparing Methods In Oncology?mentioning

confidence: 99%

The role of magnetic resonance-guided focused ultrasound in fertility sparing treatment of uterine fibroids—current perspectives

Ciebiera¹,

Łoziński²

2020

ecancer

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“…Recently, a model predictive control algorithm in combination with MR temperature mapping was introduced for a voxel-based heating strategy that allows compensation for local heat losses e.g., due to perfusion, with a high spatial resolution [39]. MR thermometry finds now routine use in all MR-HIFU applications [388,389].…”

Section: Thermometrymentioning

confidence: 99%

Heating technology for malignant tumors: a review

Kok

Cressman

Ceelen

et al. 2020

International Journal of Hyperthermia

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257

188

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The therapeutic application of heat is very effective in cancer treatment. Both hyperthermia, i.e., heating to 39-45 C to induce sensitization to radiotherapy and chemotherapy, and thermal ablation, where temperatures beyond 50 C destroy tumor cells directly are frequently applied in the clinic. Achievement of an effective treatment requires high quality heating equipment, precise thermal dosimetry, and adequate quality assurance. Several types of devices, antennas and heating or power delivery systems have been proposed and developed in recent decades. These vary considerably in technique, heating depth, ability to focus, and in the size of the heating focus. Clinically used heating techniques involve electromagnetic and ultrasonic heating, hyperthermic perfusion and conductive heating. Depending on clinical objectives and available technology, thermal therapies can be subdivided into three broad categories: local, locoregional, or whole body heating. Clinically used local heating techniques include interstitial hyperthermia and ablation, high intensity focused ultrasound (HIFU), scanned focused ultrasound (SFUS), electroporation, nanoparticle heating, intraluminal heating and superficial heating. Locoregional heating techniques include phased array systems, capacitive systems and isolated perfusion. Whole body techniques focus on prevention of heat loss supplemented with energy deposition in the body, e.g., by infrared radiation. This review presents an overview of clinical hyperthermia and ablation devices used for local, locoregional, and whole body therapy. Proven and experimental clinical applications of thermal ablation and hyperthermia are listed. Methods for temperature measurement and the role of treatment planning to control treatments are discussed briefly, as well as future perspectives for heating technology for the treatment of tumors.

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“…The most relevant clinical applications of this approach concern tissue ablation, mostly in the context of tumor treatment. Brief overviews of this group of applications, directed to clinicians, have been published in the past decade, hinting at brain, breast, prostate, and liver tumors as the primary targets (Colen et al, 2017;Cornud et al, 2018;Siedek et al, 2019aSiedek et al, , 2019b. It has also been pointed out that thermal ablation of nonneoplastic central nervous system tissue is a valid option, e.g., for patients suffering from chronic neuropathic pain (thalamotomy).…”

Section: Destroying Tissue By Heating With Ultrasound: Mrt Applications In Tissue Ablationmentioning

confidence: 99%

Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials

Lutz¹,

Bernard²

2020

iScience

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Control of temperature variation is of primordial importance in particular areas of biomedicine. In this context, medical treatments such as hyperthermia and cryotherapy, but also the development and use of hydrogel-based biomaterials are of particular concern. To enable accurate temperature measurement without perturbing or even destroying the biological tissue or material to be monitored, contactless thermometry methods are preferred. Among these, the most suitable are based on magnetic resonance imaging and spectroscopy (MRI, MRS). Here, we address the latest developments in this field as well as their current and anticipated practical applications. We highlight recent progress aimed at rendering MR thermometry faster and more reproducible, versatile and sophisticated, and provide our perspective on how these new techniques broaden the range of applications in medical treatments and biomaterial development by enabling insight into finer details of thermal behavior. Thus, these methods facilitate optimization of clinical and industrial heating and cooling protocols.

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Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Overview of Emerging Applications (Part 2)

Cited by 20 publications

References 49 publications

The role of magnetic resonance-guided focused ultrasound in fertility sparing treatment of uterine fibroids—current perspectives

The role of magnetic resonance-guided focused ultrasound in fertility sparing treatment of uterine fibroids—current perspectives

Heating technology for malignant tumors: a review

Contactless Thermometry by MRI and MRS: Advanced Methods for Thermotherapy and Biomaterials

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