Magnetic Resonance–Guided High-Intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Adenocarcinoma

Anzidei, Michele; Marincola, Beatrice Cavallo; Bezzi, Mario; Brachetti, Giulia; Nudo, F.; Cortesi, Enrico; Berloco, P.B.; Catalano, Carlo; Napoli, Alessandro

doi:10.1097/rli.0000000000000080

Cited by 42 publications

(45 citation statements)

References 31 publications

(25 reference statements)

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“…Breath-holding or gating techniques can be applied to overcome the motion of abdominal organs due to breathing [18,19]. These techniques extend the treatment time due to limited duration and repetition frequency of the anaesthesia and the reduction of active FUS exposure time.…”

Section: Respiratory Motionmentioning

confidence: 99%

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An integrated model-based software for FUS in moving abdominal organs

Schwenke

Strehlow

Haase

et al. 2015

International Journal of Hyperthermia

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Focused ultrasound surgery (FUS) is a non-invasive method for tissue ablation that has the potential for complete and controlled local tumour destruction with minimal side effects. The treatment of abdominal organs such as the liver, however, requires particular technological support in order to enable a safe, efficient and effective treatment. As FUS is applied from outside the patient's body, suitable imaging methods, such as magnetic resonance imaging or diagnostic ultrasound, are needed to guide and track the procedure. To facilitate an efficient FUS procedure in the liver, the organ motion during breathing and the partial occlusion by the rib cage need to be taken into account in real time, demanding a continuous patient-specific adaptation of the treatment configuration. Modelling the patient's respiratory motion and combining this with tracking data improves the accuracy of motion predictions. Modelling and simulation of the FUS effects within the body allows the use of treatment planning and has the potential to be used within therapy to increase knowledge about the patient status. This article describes integrated model-based software for patient-specific modelling and prediction for FUS treatments of moving abdominal organs.

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Section: Respiratory Motionmentioning

confidence: 99%

“…The first MR-guided liver ablation was performed by Okada et al in 2006 [18]. Recently, Anzidei et al [19,20] reported the successful treatment of selected patients with pancreatic adenocarcinoma and patients with a single liver tumour using a breath-holding technique under general anaesthesia.…”

Section: Fus In Abdominal Organsmentioning

confidence: 99%

An integrated model-based software for FUS in moving abdominal organs

Schwenke

Strehlow

Haase

et al. 2015

International Journal of Hyperthermia

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“…Here, especially sonographic-guided HIFU applications have already been well established, whereas MR-HIFU approaches are now upcoming therapeutic advancements. 16,[55][56][57] Especially, targeted vessel ablation by MR-HIFU could mean an interesting approach in curative as well as palliative oncologic treatments. 58 MR-HIFU treatment of breast cancer is now in development as tumor necrosis of up to 100% has been reported.…”

Section: Discussionmentioning

confidence: 99%

MR-guided high-intensity focused ultrasound treatment of uterine fibroids

Wiggermann¹,

Beldoch²,

Hoellen³

et al. 2016

RRFU

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Uterine fibroids are benign, encapsulated uterine tumors, representing the most common reason for hysterectomy in premenopausal women. High-intensity focused ultrasound (HIFU; also known as focused ultrasound surgery) is a noninvasive technique leading to tissue heating in a centered focus, inducing a thermal tissue necrosis. Magnetic resonance-guided HIFU (MR-HIFU; also know as MR-guided focused ultrasound surgery) allows to allocate the uterine fibroids as well as to evaluate whether these are accessible for HIFU treatment. Further advantages are MR-based real-time temperature mapping and immediate evaluation of postprocedure therapeutic success by MR imaging. These advantages minimize the patient risk and make the treatment more effective. MR-HIFU is a uterus conserving, low pain-to-painless, and noninvasive treatment option. Here, we review its medical and economic advance to surgical procedures due to the low complication rates combined with proven symptom relief and the enhancement of the quality of life.

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“…[27][28][29][30][31] In addition, several applications have been tested in fields other than oncology, including MSK diseases and neurology (e.g. essential tremor, neuropathic pain etc.).…”

Section: Mrgfus Lessons Learned From Non-musculoskeletal Applicationsmentioning

confidence: 99%

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Bazzocchi¹,

Napoli²,

Sacconi³

et al. 2016

BJR

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MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice. Both the imaging and therapeutic sides of the equipment are based on non-ionizing energy. This technique is a very promising option as potential treatment for several pathologies, including musculoskeletal (MSK) disorders. Apart from clinical applications, MRgFUS technology is the result of long, heavy and cumulative efforts exploring the effects of ultrasound on biological tissues and function, the generation of focused ultrasound and treatment monitoring by MRI. The aim of this article is to give an updated overview on a "new" interventional technique and on its applications for MSK and allied sciences

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Magnetic Resonance–Guided High-Intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Adenocarcinoma

Abstract: Our preliminary clinical experience suggests that MRgFUS is a feasible and repeatable ablative technique in selected patients with unresectable and device-accessible pancreatic adenocarcinoma.

Cited by 42 publications

References 31 publications

An integrated model-based software for FUS in moving abdominal organs

An integrated model-based software for FUS in moving abdominal organs

MR-guided high-intensity focused ultrasound treatment of uterine fibroids

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

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