Magnetic resonance follow-through imaging for evaluation of disease activity in ileal Crohnʼs disease

Abstract

MRFT provides accurate information on ileal CD activity, with close agreement to inflammatory markers and histopathology. It represents a substantial advance in the staging of CD, while avoiding painful enteroclysis and radiation exposure in young patients.

Fecal Calprotectin in Ileal Crohnʼs Disease

“…A positive correlation was observed between FC concentration and moderate or severe inflammatory activity, whereas no correlation was found with CRP, the classical inflammatory parameter. This is in line with the results of previous study, 17 showing FC to be the biomarker that best correlated with histopathological findings, whereas a poor correlation was reported between histology and CRP, as we have observed. Furthermore, we have used a score for classification of histologic findings, which confers our study more objectivity.…”

“…The few that do exist suggest accordance between FC values and the degree of inflammation observed in MRE. [16][17][18] The aim of the present study was to evaluate the relevance of FC levels for assessing small bowel CD activity, and its potential application for identifying patients that require MRE (and those in whom it should be avoided), before clinical decision-making.…”

Magnetic Resonance Enterography for Crohn’s Disease: What the Surgeon Can Take Home

“…Furthermore, only few studies compared MRE findings and intraoperative findings. 24,[27][28][29] However, all these studies were focused on the evaluation of disease activity in CD as a key point in the decision making between medical and surgical treatment. As far as we know, no study was focused on surgical details that could be useful in the further step of planning surgical procedures.…”

Comprehensive Magnetic Resonance Enterography of Crohn׳s Disease in the Pediatric Population: Technique, Interpretation, and Management

“…45 Although signs such as mural "cobbelstoning" (linear and transverse ulcerations of the mucosal surface) have been described, 14 evaluation of mucosal disease, especially at its early stages, should be correlated to findings of endoscopy or small bowel follow through. 10 MR enteroclysis, which can produce more uniform small bowel distention and provide better detail of the mucosal surface, is rarely performed at our institution because of significant discomfort and added radiation associated with fluoroscopically guided nasojejunal intubation.…”