Magnetic resonance evaluation of human mesenchymal stem cells in corpus cavernosa of rats and rabbits

Abstract

SPIO-labeled hMSCs in corpus cavernosa of rats and rabbits can be evaluated non-invasively by molecular MR imaging. Our findings suggest that MR imaging has the ability to test the long-term therapeutic potential of hMSCs in animals in the setting of erectile dysfunction.

In vivo magnetic resonance tracking of Feridex-labeled bone marrow-derived neural stem cells after autologous transplantation in rhesus monkey

“…Some research groups have demonstrated that SPIO labeling of stem cells or progenitor cells from rats or mice is feasible, efficient and safe for MRI tracing (Arbab et al, 2005;Song et al, 2007). Recently, Farrell et al demonstrated that long term SPIO labeling of BMSCs uninhibited multilineage BMSCs differentiation (osteogenic, chondrogenic and adipogenic) and could be traced by MRI (Farrell et al, 2008), Lepore et al also demonstrated that BMSCs derived from neural precursor cells from the SD rat could be labeled with Feridex and reliably localized by MRI following engraftment into the CNS (Lepore et al, 2006).…”

“…Some studies have shown that transplanted BMSCs labeled with Feridex are detected by MRI (Arbab et al, , 2005Song et al, 2007). However, there have been no studies describing MRI tracking of Feridex-labeled BMSCs-D-NSCs after autologous transplantation in senior primates.…”

Superparamagnetic iron oxide nanoparticle targeting of adipose tissue-derived stem cells in diabetes-associated erectile dysfunction

“…Some studies have employed SPIONs, which are typically used as a magnetic resonance imaging contrast agent, to label stem cells and investigate their fate after injection or to guide them to target areas by magnetic field application 3233. In the current study, we demonstrated that SPIONs were effectively incorporated into ADSCs without influencing ADSC proliferation or viability in vitro .…”

137 Superparamagnetic Iron Oxide Nanoparticle Targeting of Adipose Tissue-Derived Stem Cells in Diabetes-Associated Erectile Dysfunction

“…Some studies have employed SPIONs, which are typically used as a magnetic resonance imaging contrast agent, to label stem cells and investigate their fate after injection or to guide them to target areas by magnetic field application. 32,33 In the current study, we demonstrated that SPIONs were effectively incorporated into ADSCs without influencing ADSC proliferation or viability in vitro. Application of an external magnetic field improved the in vivo homing efficiency of SPION-labeled ADSCs to the corpus cavernosum region in a rat model of DED.…”