Magnetic Resonance Enterography Healing and Magnetic Resonance Enterography Remission Predicts Improved Outcome in Pediatric Crohn Disease

Sauer, Cary G.; Middleton, Jeremy P.; McCracken, Courtney; Loewen, Jonathan; Braithwaite, Kiery; Alazraki, Adina; Martín, Diego R.; Kugathasan, Subra

doi:10.1097/mpg.0000000000000976

Cited by 47 publications

(54 citation statements)

References 30 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cross-sectional imaging was initially used to detect and stage Crohn's disease (5), but it is increasingly being used to gauge therapeutic response (4,13), providing objective measures to guide treatment decisions that can potentially alter the natural history of the disease (14). Mucosal healing as detected by colonoscopy in Crohn's disease results in improved outcome (15)(16)(17)(18); however, more recently, cross-sectional imaging, primarily MRE, has demonstrated a high correlation between mucosal healing at endoscopy and transmural healing at cross-sectional imaging, with improved outcomes when detected (19)(20)(21). Thus, there needs to be a shared understanding of the goals of imaging between referring clinicians and C omputed tomography enterography (CTE) and magnetic resonance enterography (MRE) have emerged as the most effective methods for imaging the small bowel in patients with Crohn's disease (1,2).…”

mentioning

confidence: 99%

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease

et al. 2018

Self Cite

View full text Add to dashboard Cite

Computed tomography and magnetic resonance enterography have become routine small bowel imaging tests to evaluate patients with established or suspected Crohn's disease, but the interpretation and use of these imaging modalities can vary widely. A shared understanding of imaging findings, nomenclature, and utilization will improve the utility of these imaging techniques to guide treatment options, as well as assess for treatment response and complications. Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society of Pediatric Radiology, the American Gastroenterological Association, and other experts, systematically evaluated evidence for imaging findings associated with small bowel Crohn's disease enteric inflammation and established recommendations for the evaluation, interpretation, and use of computed tomography and magnetic resonance enterography in small bowel Crohn's disease. This work makes recommendations for imaging findings that indicate small bowel Crohn's disease, how inflammatory small bowel Crohn's disease and its complications should be described, elucidates potential extra-enteric findings that may be seen at imaging, and recommends that cross-sectional enterography should be performed at diagnosis of Crohn's disease and considered for small bowel Crohn's disease monitoring paradigms. A useful morphologic construct describing how imaging findings evolve with disease progression and response is described, and standard impressions for radiologic reports that convey meaningful information to gastroenterologists and surgeons are presented. 2018, RSNA, AGA Institute, and Society of Abdominal Radiology This article is being published jointly in Radiology and Gastroenterology.

show abstract

mentioning

confidence: 99%

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Study results suggest that MRE may be a surrogate for ileocolonoscopy in the assessment of mucosal healing in adults [17,21]. A recent study with pediatric subjects [22] revealed a correlation between imaging remission at MRE and improved clinical outcomes, including higher rates of clinical remission, fewer medication changes, and fewer surgical procedures. To our knowledge, however, no studies have validated the correlation between MRE and endoscopic findings of mucosal healing in the pediatric population.…”

Section: Resultsmentioning

confidence: 97%

MR Enterographic Findings as Biomarkers of Mucosal Healing in Young Patients With Crohn Disease

Moy

Kaplan

Moran

et al. 2016

American Journal of Roentgenology

View full text Add to dashboard Cite

show abstract

“…When no signs of active inflammation on MRE are found, the disease outcome during the following year seems to be excellent in most patients [102]. Yet, it may well be that uniform criteria for e.g.…”

Section: Improvements In Imagingmentioning

confidence: 99%

Progress in the treatment and outcome of pediatric inflammatory bowel disease patients

Kolho

Ainamo

2016

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

The number of pediatric patients with inflammatory bowel disease (IBD), namely Crohn´s disease, ulcerative colitis and unclassified colitis, has rapidly increased in Western countries. Areas covered: This review discusses how the treatment of pediatric IBD patients has improved,with attention given to therapeutic quality and cost. The literature search covers Medline-PubMed and the Cochrane Library, with February 2016 as the last search dates. Similarly to what has been the trend in the management of adult IBD, pediatric IBD therapy has become more active than before. High use of immunosuppressants and the availability of biological therapeutic agents has helped to control the extensive and aggressive course of pediatric IBD. Full disease control at an early phase has advantages such as preserving normal child growth and development, maintaining overall good health and quality of life, as well as decreasing the psychosocial burden of the disease. Expert commentary: A key research direction is to tailor treatment modalities according to anticipated individual phenotype and disease course. Another is to reduce healthcare costs by decreasing the so-far high rate of surgery of pediatric IBD patients, and, instead, to develop a more active approach to treatment than before.

show abstract

Magnetic Resonance Enterography Healing and Magnetic Resonance Enterography Remission Predicts Improved Outcome in Pediatric Crohn Disease

Cited by 47 publications

References 30 publications

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease

Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn’s Disease

MR Enterographic Findings as Biomarkers of Mucosal Healing in Young Patients With Crohn Disease

Progress in the treatment and outcome of pediatric inflammatory bowel disease patients

Contact Info

Product

Resources

About