Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child

D’Angelo, Tommaso; Gallizzi, Romina; Romano, Claudio; Cicero, Giuseppe; Mazziotti, Silvio

doi:10.1155/2017/8061648

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…The most prevalent described GIT manifestations associated with BD are abdominal pain, diarrhea and bleeding (35) , mostly being mild symptoms (36) . After long-term follow-up and clinical management, only one patient persisted with bleeding.…”

Section: Discussionmentioning

confidence: 99%

Small Bowel Is Largely Affected in Behçet’s Disease: A Long-Term Follow-Up of Gastrointestinal Symptoms

Facanali

Ribeiro

et al. 2022

Arq. Gastroenterol.

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Background Behçet’s disease is a rare immune-mediated disorder that can affect the gastrointestinal tract. The prevalence and extension of small bowel involvement is largely unknown. Objective The aim of this study was to describe the small bowel lesions diagnosed by double-balloon enteroscopy (DBE) and to verify if these findings were associated to the presence of gastrointestinal symptoms and disease activity after long-term follow-up. Methods This study included 19 Behçet’s disease patients who underwent DBE. After a mean follow-up of 15 years the endoscopic findings were associated to the presence of gastrointestinal symptoms, disease activity and current therapy through collection of electronic medical records. Results A total of 63.2% patients were female and the mean age was 37 years at the time of DBE. Mean disease duration at baseline was 24 years. 11 patients had no gastrointestinal symptoms and eight patients presented either abdominal pain, gastrointestinal bleeding or diarrhea. The average procedure time was 1 hour and 30 minutes and the ileum was achieved in all patients but one. Small bowel ulcers were diagnosed in 78.9%, with 63.1% of jejunal involvement. Two patients presented only small bowel edema and two were normal by DBE. Eight patients had concomitant gastric ulcers. Gastrointestinal symptoms prior to DBE were present in 36.8% of the patients and, after follow-up, all of them persisted with some of the symptoms. Bleeding was reported by three patients at baseline and persisted in only one patient. The frequency of treatment with steroids and immunomodulators was 31.6% and 57.9% at baseline, respectively, and 21% in both at the end of the follow-up. No patient was treated with biologics at the time of the DBE procedure and the current rate of biologic use is 21%. Conclusion Small bowel involvement in Behçet’s disease was frequently demonstrated by DBE even in asymptomatic patients. Understanding clinical evolution of the disease over the years and the impact of such diagnosis still represents a challenge, possibly with the need for novel treatment.

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Section: Discussionmentioning

confidence: 99%

Small Bowel Is Largely Affected in Behçet’s Disease: A Long-Term Follow-Up of Gastrointestinal Symptoms

Facanali

Ribeiro

et al. 2022

Arq. Gastroenterol.

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“…61 MRE has also been successfully applied in intestinal conditions other than CD. [62][63][64] However, this concept implies that, similarly to other imaging modalities, the radiological findings are not pathognomonic of CD and correlation with laboratory tests and endoscopic features is mandatory for a definitive diagnosis.…”

Section: ) Techniquesmentioning

confidence: 99%

Crohn’s disease at radiological imaging: focus on techniques and intestinal tract

Cicero

Mazziotti

2021

Intest Res

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noscopy with biopsy is considered the reference standard for achieving a definitive diagnosis, as it can access hard-to-reach areas of the small intestine and can replace surgery in treatment of strictures through balloon dilation. 7 However, the main limits include invasiveness, related risks (i.e., bowel perforation) and a partial evaluation, limited to the mucosal surface. 8 Therefore, radiological imaging is of paramount importance in the estimation of the whole intestinal involvement, not only for the initial evaluation, but also for follow-up monitoring and treatment response assessment. 9,10 Beyond the mere detection of intestinal lesions, it can provide useful data concerning characteristics of bowel wall thickening, which is helpful in distinguishing active inflammation from fibrosis, along with and valuable information on the surrounding tissues, where complications arise. 11 The constant development of novel technical tools and techniques is a benefit for improving the patient' s clinical framework. On the other hand, the different imaging modalities and the number of tools and techniques they are provided with can be confounding while establishing the prop

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“…17 A 12-year-old female patient with neurological and gastrointestinal involvement was reported. 41 She admitted with a cranial headache, stiff neck, oculomotor and facial nerve paresis on the left side, and hemiparesis. She was treated with prednisone, cyclophosphamide, and mycophenolate mofetil.…”

Section: Rheumatological Manifestations Of Behçet's Diseasementioning

confidence: 99%

Behçet's Disease from Rheumatology and Neurology Perspectives with Special Reference to Children

Turgut

Tosun

Yüzbaşı

et al. 2019

Journal of Pediatric Neurology

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AbstractBehçet's disease (BD) is an idiopathic chronic relapsing multisystemic vascular inflammatory disease. Although it is generally seen in young adults with male predominance, the onset age of the disease is the pediatric age group in only 4 to 26% of all cases of BD. According to the International Study Group for Behçet's Disease Classification Criteria, a diagnosis of BD requires recurrent oral aphthous ulcerations with two of the following: genital ulcerations, skin lesions, eye lesions, or a positive pathergy test. In this article, we extensively reviewed the current literature with respect to the rheumatological and neurological findings of BD in childhood.

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Magnetic Resonance Enterography Findings of Intestinal Behçet Disease in a Child

Cited by 6 publications

References 11 publications

Small Bowel Is Largely Affected in Behçet’s Disease: A Long-Term Follow-Up of Gastrointestinal Symptoms

Small Bowel Is Largely Affected in Behçet’s Disease: A Long-Term Follow-Up of Gastrointestinal Symptoms

Crohn’s disease at radiological imaging: focus on techniques and intestinal tract

Behçet's Disease from Rheumatology and Neurology Perspectives with Special Reference to Children

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