Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging

Wang, Kun; Zhang, Huilin; Shen, Ai; Zhao, Peiran; Meng, Xianfu; Chen, Xiaoyan; Liu, Yang; Liu, Yanyan; Gong, Teng; Wu, Wanlu; Fang, Xiangming; Wang, Peijun; Bu, Wenbo

doi:10.1016/j.biomaterials.2019.119703

Cited by 13 publications

(8 citation statements)

References 44 publications

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“…For example, glutathione is overexpressed in cancer cells (up to 10 × 10 −3 m), which is an important pathway to protect cells from oxidative damage by ROS scavenging. [ 7 ] Moreover, another important representative phenomenon is the production of excessive content of catalase (CAT). [ 8 ] CAT is an essential antioxidant enzyme in cells, which plays a crucial role in maintaining the balance of intracellular ROS by decomposition of H 2 O 2 and decreasing highly toxic ·OH production by intracellular iron through H 2 O 2 .…”

Section: Figurementioning

confidence: 99%

FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance

et al. 2020

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Therapeutic systems to induce reactive oxygen species (ROS) have received tremendous success in the research of tumor theranostics, but suffered daunting challenges in limited efficacy originating from low presence of reactants and reaction kinetics within cancer cells. Here, ferrous sulfide‐embedded bovine serum albumin (FeS@BSA) nanoclusters, in an amorphous nature, are designed and synthesized via a self‐assembly approach. In acidic conditions, the nanoclusters degrade and simultaneously release H2S gas and Fe2+ ions. The in vitro study using Huh7 cancer cells reveals that Fe2+ released from FeS@BSA nanoclusters induces the toxic hydroxyl radical (·OH) effectively via the Fenton reaction. More interestingly, H2S gas released intracellularly presents the specific suppression effect to catalase activity of cancer cells, resulting in the promoted presence of H2O2 that facilitates the Fenton reaction of Fe2+ and consequently promotes ROS induction within the cells remarkably. After intravenous administration, the nanoclusters accumulate in the tumors of mice via the enhanced permeability and retention effect and present strong magnetic resonance imaging (MRI) signals. The findings confirm this therapeutic system can enable superior anti‐tumor performance with MRI guidance and negligible side effects. This study, therefore, offers an alternative gas‐amplified ROS‐based therapeutic platform for synergetic tumor treatment.

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Section: Figurementioning

confidence: 99%

FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance

et al. 2020

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“…Moreover, besides the common function of anatomical MRI, contrast agents based on nanomaterials can also be exploited for functional MRI applications, such as the real-time monitorization of the tumor temperature induced by photothermal therapy and the detection of specific molecule concentrations present in the tumor microenvironment. [5,6] Taking this into consideration, promising in vitro and preclinical results have been demonstrated, ending up with magnetic nanoparticles for example, already included in clinical programs. [7] When it comes to magnetic nanoparticles, their magnetic moment is capable of inducing field inhomogeneities in the surrounding environment (typically composed by water molecules when the nanoparticles are immersed in tissue) when a radiofrequency pulse is applied.…”

Section: Introductionmentioning

confidence: 99%

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Díez‐Villares

Ramos-Docampo

Silva‐Candal

et al. 2021

Adv Healthcare Materials

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Magnetic resonance imaging (MRI) is one of the most powerful non-invasive imaging modalities used in clinics due to its great spatial resolution and excellent soft-tissue contrast, though still less sensitive than other techniques such as the nuclear imaging modalities. This lack of sensitivity can be improved with the use of contrast agents based on nanomaterials. In recent years, researchers have focused on the development of magnetic nanoparticles, given their role as enhancers of the contrast signal based on the magnetic resonance. Manganese ferrite nanoparticles stand out, given their high magnetic susceptibility and magnetic soft nature. Herein, 10 nm MnFe 2 O 4 nanoparticles, functionalized with the natural antioxidant vitamin E (VitE-MFO) are encapsulated into simple, biodegradable and non-toxic nanoemulsions (NEs), by a reproducible one-step method obtaining stable 150 nm-sized magnetic nanoemulsions (VitE-MFO-NEs). After encapsulation, the superparamagnetic properties of VitE-MFO are maintained and MR imaging studies reveal an extremely high transverse relaxivity for VitE-MFO-NEs (652.9 × 10 −3 m −1 s −1 ), twofold higher than VitE-MFO value. Moreover, VitE-MFO-NEs show great in vivo biocompatibility and good signal in in vivo and ex vivo MRI, which indicates their great potential for biomedical imaging enhancing the negative MR contrast and significantly improving the sensitivity of MRI.

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“…The variation SWI signals in this process can be used for high-sensitive in vivo GSH concentration detection. [56] In another work, Hou et al constructed a T 1 /T 2 dual-modality MR Imaging theranostic nanoprobe on the basis of protein corona coated Fe 3 O 4 nanoparticles and biomineralization inside the corona. Specifically, the bovine serum albumin (BSA) molecules adsorbed on the carboxylic Fe 3 O 4 nanoparticles were served as the matrixes for biomimetically mineralizing Fe 3+ ion with tannic acid (TA).…”

Section:  Activatable T  Nanoprobementioning

confidence: 99%

Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”

Zhang,

Li,

Liu

et al. 2023

Exploration

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Although the extraordinary progress has been made in molecular biology, the prevention of cancer remains arduous. Most solid tumours exhibit both spatial and temporal heterogeneity, which is difficult to be mimicked in vitro. Additionally, the complex biochemical and immune features of tumour microenvironment significantly affect the tumour development. Molecular imaging aims at the exploitation of tumour‐associated molecules as specific targets of customized molecular probe, thereby generating image contrast of tumour markers, and offering opportunities to non‐invasively evaluate the pathological characteristics of tumours in vivo. Particularly, there are no “standard markers” as control in clinical imaging diagnosis of individuals, so the tumour pathological characteristics‐responsive nanoprobe‐based quantitative molecular imaging, which is able to visualize and determine the accurate content values of heterogeneous distribution of pathological molecules in solid tumours, can provide criteria for cancer diagnosis. In this context, a variety of “smart” quantitative molecular imaging nanoprobes have been designed, in order to provide feasible approaches to quantitatively visualize the tumour‐associated pathological molecules in vivo. This review summarizes the recent achievements in the designs of these nanoprobes, and highlights the state‐of‐the‐art technologies in quantitative imaging of tumour‐associated pathological molecules.

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Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging

Cited by 13 publications

References 44 publications

FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance

FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”

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Magnetic resonance energy transfer for in vivo glutathione susceptibility weighted imaging

Cited by 13 publications

References 44 publications

FeS@BSA Nanoclusters to Enable H2S‐Amplified ROS‐Based Therapy with MRI Guidance

FeS@BSA Nanoclusters to Enable H2S‐Amplified ROS‐Based Therapy with MRI Guidance

Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High‐Sensitive Magnetic Resonance Imaging

Molecular imaging of tumour‐associated pathological biomarkers with smart nanoprobe: From “Seeing” to “Measuring”

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FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance

FeS@BSA Nanoclusters to Enable H₂S‐Amplified ROS‐Based Therapy with MRI Guidance