Magnetic Resonance Elastography of the Brain

Nanjappa, Manjunathan; Kolipaka, Arunark

doi:10.1016/j.mric.2021.06.011

Cited by 10 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elasticity is a physical parameter that reflects the stiffness of a material. 34 Stiffness is the resistance of viscoelastic tissue when deformed under an applied pressure, usually in kilopascal. The greater the value, the stiffer the tissue and the smaller the deformation when pressure is applied.…”

Section: Cerebral Viscoelasticity Change Theorymentioning

confidence: 99%

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians

Li,

Lin,

Yang

2024

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

Low-/negative-pressure hydrocephalus (LPH/NePH) is uncommon in clinical practice, and doctors are unfamiliar with it. LPH/NePH is frequently caused by other central nervous system diseases, and patients are frequently misdiagnosed with other types of hydrocephalus, resulting in delayed treatment. LPH/NePH therapy evolved to therapeutic measures based on “external ventricular drainage below atmospheric pressure” as the number of patients with LPH/NePH described in the literature has increased. However, the mechanism of LPH/NePH formation is unknown. Thus, understanding the process of LPH/NePH development is the most important step in improving diagnosis and treatment capability. Based on case reports of LPH/NePH, we reviewed theories of transcortical pressure difference, excessive cerebral venous drainage, brain viscoelastic changes, and porous elastic sponges.

show abstract

Section: Cerebral Viscoelasticity Change Theorymentioning

confidence: 99%

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians

Li,

Lin,

Yang

2024

J Neurol Surg A Cent Eur Neurosurg

View full text Add to dashboard Cite

show abstract

“…[ 29 ] Previous studies reported that specific brain regions showed variability of stiffness in normal humans by magnetic resonance elastography (MRE), which is an imaging technique for noninvasively and quantitatively assessing tissue stiffness. [ 27a,30 ] Moreover, the measurement of MRE showed that the adult human brain appeared to be 3–4 times stiffer than the young child's brain. [ 31 ] The finding suggests that brain maturation is associated with increasing tissue stiffness.…”

Section: Physical Microenvironment In Neurogenesis Neurodevelopment A...mentioning

confidence: 99%

Engineering the Physical Microenvironment into Neural Organoids for Neurogenesis and Neurodevelopment

Li,

Sun,

Hou

et al. 2023

Small

View full text Add to dashboard Cite

Understanding the signals from the physical microenvironment is critical for deciphering the processes of neurogenesis and neurodevelopment. The discovery of how surrounding physical signals shape human developing neurons is hindered by the bottleneck of conventional cell culture and animal models. Notwithstanding neural organoids provide a promising platform for recapitulating human neurogenesis and neurodevelopment, building neuronal physical microenvironment that accurately mimics the native neurophysical features is largely ignored in current organoid technologies. Here, it is discussed how the physical microenvironment modulates critical events during the periods of neurogenesis and neurodevelopment, such as neural stem cell fates, neural tube closure, neuronal migration, axonal guidance, optic cup formation, and cortical folding. Although animal models are widely used to investigate the impacts of physical factors on neurodevelopment and neuropathy, the important roles of human stem cell‐derived neural organoids in this field are particularly highlighted. Considering the great promise of human organoids, building neural organoid microenvironments with mechanical forces, electrophysiological microsystems, and light manipulation will help to fully understand the physical cues in neurodevelopmental processes. Neural organoids combined with cutting‐edge techniques, such as advanced atomic force microscopes, microrobots, and structural color biomaterials might promote the development of neural organoid‐based research and neuroscience.

show abstract

“…MRE is a phase-contrast magnetic resonance imaging (MRI) technique that can non-invasively measure in vivo tissue viscoelastic properties by measuring the three-dimensional (3D) shear wave displacement field produced during the propagation of acoustic waves generated by an external mechanical vibration source [ 10 11 ]. Although its application has been studied extensively in the liver, MRE has also been applied to the brain, suggesting that numerous neurological conditions associated with glymphatic dysfunction (e.g., Alzheimer's disease, Parkinson’s disease, normal pressure hydrocephalus, multiple sclerosis, and brain aging) exhibit significant findings on MRE [ 11 12 13 14 15 16 17 18 ].…”

Section: Introductionmentioning

confidence: 99%

Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals

et al. 2023

View full text Add to dashboard Cite

Objective To investigate the feasibility of assessing the viscoelastic properties of the brain using magnetic resonance elastography (MRE) and a novel MRE transducer to determine the relationship between the viscoelastic properties and glymphatic function in neurologically normal individuals. Materials and Methods This prospective study included 47 neurologically normal individuals aged 23–74 years (male-to-female ratio, 21:26). The MRE was acquired using a gravitational transducer based on a rotational eccentric mass as the driving system. The magnitude of the complex shear modulus |G*| and the phase angle φ were measured in the centrum semiovale area. To evaluate glymphatic function, the Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) method was utilized and the ALPS index was calculated. Univariable and multivariable (variables with P < 0.2 from the univariable analysis) linear regression analyses were performed for |G*| and φ and included sex, age, normalized white matter hyperintensity (WMH) volume, brain parenchymal volume, and ALPS index as covariates. Results In the univariable analysis for |G*|, age ( P = 0.005), brain parenchymal volume ( P = 0.152), normalized WMH volume ( P = 0.011), and ALPS index ( P = 0.005) were identified as candidates with P < 0.2. In the multivariable analysis, only the ALPS index was independently associated with |G*|, showing a positive relationship (β = 0.300, P = 0.029). For φ, normalized WMH volume ( P = 0.128) and ALPS index ( P = 0.015) were identified as candidates for multivariable analysis, and only the ALPS index was independently associated with φ (β = 0.057, P = 0.039). Conclusion Brain MRE using a gravitational transducer is feasible in neurologically normal individuals over a wide age range. The significant correlation between the viscoelastic properties of the brain and glymphatic function suggests that a more organized or preserved microenvironment of the brain parenchyma is associated with a more unimpeded glymphatic fluid flow.

show abstract

Magnetic Resonance Elastography of the Brain

Cited by 10 publications

References 59 publications

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians

Engineering the Physical Microenvironment into Neural Organoids for Neurogenesis and Neurodevelopment

Viscoelastic Property of the Brain Assessed With Magnetic Resonance Elastography and Its Association With Glymphatic System in Neurologically Normal Individuals

Contact Info

Product

Resources

About