Magnetic resonance elastography of skeletal muscle

Dresner, M. Alex; Rose, Gregory H.; Rossman, Phillip J.; Muthupillai, Raja; Manduca, Armando; Ehman, Richard L.

doi:10.1002/1522-2586(200102)13:2<269::aid-jmri1039>3.0.co;2-1

Cited by 269 publications

(262 citation statements)

References 34 publications

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“…Previous studies of muscle tissue elasticity using MRE have shown that muscle stiffness increases with increasing load (9,10). Muscle stiffness has also been shown to vary between muscle groups, gender (7), and degree of muscle load (11).…”

Section: Introductionmentioning

confidence: 99%

Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography

et al. 2007

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Purpose: We sought to determine whether differences in muscle elasticity between healthy age-related controls and patients with hypogonadism could be measured by a new, non-invasive method termed magnetic resonance elastography (MRE). Materials and methods: Twelve hypogonadal (21-68 years) and twenty-seven healthy age-related men (20-76 years) were examined. In the hypogonadism group, serum testosterone levels were compared and MRE was conducted prior to and after 6 months of therapy in 6 of the 12 patients. MRE was performed by mechanically exciting the soleus muscle that was used because of its uniformly distributed muscle fibers, size, and accessibility, with a custom designed piezoelectric-actuator using a modified phase-contrast sequence. For mechanical excitation the actuator lever was placed on the anterior surface of the calf. The subjects had to maintain a force of 0-20% of their maximum voluntary contraction against a home-built footplate that was mounted on the MR table. All images were phase unwrapped and reconstructed into shear modulus elastograms using the local frequency estimation technique. Results: Testosterone levels were significantly higher after 6 months of treatment. A statistical difference in the shear modulus was observed prior to and after 6 months of testosterone therapy and was nearly the same as in the healthy age-related control group. Conclusion: MRE seems to be a promising technique for the evaluation of therapeutic effects in patients with hypogonadism and possibly in other diseases with muscular effects.European Journal of Endocrinology 156 673-678

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Section: Introductionmentioning

confidence: 99%

Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography

et al. 2007

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“…MR Elastography can be readily implemented on standard MR imaging systems with little additional hardware (21). To date, MR Elastography has been applied to quantitatively assess the viscoelastic properties of many human tissues in vivo, including breast, brain, muscle, and liver (22)(23)(24)(25)(26)(27)(28)(29). Preliminary studies in human subjects have confirmed the feasibility and promise of this technique for the quantitative assessment of hepatic fibrosis (27,28).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Yin

Talwalkar

Glaser

et al. 2007

Clinical Gastroenterology and Hepatology

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809

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Background & Aims-Accurate detection of hepatic fibrosis is crucial for assessing prognosis and candidacy for treatment in patients with chronic liver disease. Magnetic Resonance (MR) Elastography, a technique for quantitatively assessing the mechanical properties of soft tissues, has previously been shown to have potential for non-invasively detecting liver fibrosis. The goal of this work was to obtain preliminary estimates of the sensitivity and specificity of the technique in diagnosing liver fibrosis, and to assess its potential for identifying patients who can potentially avoid biopsy.

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“…Laboratory techniques for assessing tone and mechanical properties objectively, such as ultrasound imaging with dynamometry (Narici et al 1996;Muraoka et al 2005) and magnetic resonance elastography (Dresner et al 2001) are not clinically feasible. There is the need for objective, reliable, valid, robust, easy to use and cost effective ways of assessing skeletal muscle tone and mechanical properties in a clinical setting.…”

Section: Introductionmentioning

confidence: 99%

Measurement of ageing effects on muscle tone and mechanical properties of rectus femoris and biceps brachii in healthy males and females using a novel hand-held myometric device

Agyapong‐Badu

Warner

Samuel

et al. 2016

Archives of Gerontology and Geriatrics

134

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Please cite this article as: Agyapong-Badu, Sandra, Warner, Martin, Samuel, Dinesh, Stokes, Maria, Measurement of ageing effects on muscle tone and mechanical properties of rectus femoris and biceps brachii in healthy males and females using a novel hand-held myometric device.Archives of Gerontology and Geriatrics http://dx.doi.org/10. 1016/j.archger.2015.09.011 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Monitoring changes in muscle properties with ageing in community settings may provide a valuable assessment tool for detecting those at risk of premature decline and sarcopenia.Objective: This study aimed to provide objective data on the effects of ageing and gender on muscle tone and mechanical properties of quadriceps (rectus femoris) and biceps brachii muscles.Methods: In a comparative study of 123 healthy males and females (aged 18-90 years; n=61 aged18-35; n=62 aged 65-90) muscle tone, elasticity and stiffness were measured using the MyotonPRO device.Results: Stiffness was greater and elasticity lower in older adults for BB and RF (p<0.001). Tone was significantly greater in older adults for BB but not for RF when data for males and females were combined (p=0.28). There were no gender differences for BB in either age group. In RF, males had greater stiffness (young males 292 vs females 233 N/m; older males 328 vs females 311 N/m) and tone (young 16.4 vs 13.6 Hz; older 16.7 vs 14.9 Hz).Elasticity in RF was lower in young males than females but did not differ between the older groups (both males and females log decrement 1.6).Conclusions: Stiffness and tone increased with ageing and elasticity decreased. These findings have implications for detecting frailty using a novel biomarker. Age and gender differences are important to consider when assessing effects of pathological conditions on muscle properties in older people.

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Magnetic resonance elastography of skeletal muscle

Cited by 269 publications

References 34 publications

Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography

Changes in calf muscle elasticity in hypogonadal males before and after testosterone substitution as monitored by magnetic resonance elastography

Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography

Measurement of ageing effects on muscle tone and mechanical properties of rectus femoris and biceps brachii in healthy males and females using a novel hand-held myometric device

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