Magnetic resonance elastography of liver and spleen: Methods and applications

Garteiser, Philippe; Doblas, Sabrina; Beers, Bernard E. Van

doi:10.1002/nbm.3891

Cited by 32 publications

(32 citation statements)

References 180 publications

(550 reference statements)

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“…[11][12][13][14][15][16][17][18][19] MRE is a clinically proven tool to stage liver fibrosis and is currently being investigated as a potential clinical tool to estimate stiffness in other organs such as aorta, 11 heart, 12 brain, 15 pancreas, 16 lungs, 17 intervertebral discs, 18 liver and spleen. 19 Preliminary studies have been conducted using MRE in kidneys to determine stiffness in healthy subjects 3,20,21 and the effect of water intake on renal stiffness. 22,23 Other noninvasive imaging techniques such as arterial spin labeling (ASL) and dynamic contrast-enhancement are being used to asses perfusion in the kidneys.…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion

et al. 2019

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Stiffness plays an important role in diagnosing renal fibrosis. However, kidney stiffness is altered by perfusion changes in many kidney diseases. Therefore, the aim of the current study is to determine the correlation of kidney stiffness with water intake. We hypothesize that kidney stiffness will increase with 1 L of water intake due to increased water perfusion to the kidneys. Additionally, stiffness of the kidneys will correlate with apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values before and after water intake. A 3 T MRI scanner was used to perform magnetic resonance elastography and diffusion tensor imaging of the kidneys on 24 healthy subjects (age range: 22‐66 years) before and after water intake of 1 L. A 3D T1‐weighted bladder scan was also performed to measure bladder volume before and after water intake. A paired t‐test was performed to evaluate the effect of water intake on the stiffness of kidneys, in addition to bladder volume. A Spearman correlation test was performed to determine the association between stiffness, bladder volume, ADC and FA values of both kidneys before and after water intake. The results show a significant increase in stiffness in different regions of the kidney (ie, percentage increase ranged from 3.6% to 7.5%) and bladder volume after water intake (all P < 0.05). A moderate significant negative correlation was observed between change in kidney stiffness and bladder volume (concordance correlation coefficient = ‐0.468, P < 0.05). No significant correlation was observed between stiffness and ADC or FA values before and after water intake in both kidneys (P > 0.05). Water intake caused a significant increase in the stiffness of the kidneys. The negative correlation between the change in kidney stiffness and bladder volume, before and after water intake, indicates higher perfusion pressure in the kidneys, leading to increased stiffness.

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Section: Introductionmentioning

confidence: 99%

Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion

et al. 2019

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“…[20][21][22][23][24] MRE is also being evaluated for determining in-vivo stiffness in brain, 25 heart, 14 aorta, 13 pancreas, 26 lungs, 27 intervertebral discs 28 and spleen. 29 Few studies have evaluated renal MRE in healthy humans [30][31][32][33][34] and animals [35][36][37] but these studies have been limited to feasibility. However, it is important to accelerate MRE to obtain multiple slices in a breath-hold, which can be achieved using a spin echo-echo planar imaging (SE-EPI) MRE.…”

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confidence: 99%

Magnetic Resonance Elastography of kidneys: SE‐EPI MRE reproducibility and its comparison to GRE MRE

et al. 2019

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The purpose of this study is 1) to demonstrate reproducibility of spin echo‐echo planar imaging (SE‐EPI) magnetic resonance elastography (MRE) to estimate kidney stiffness; and 2) to compare SE‐EPI MRE and gradient recalled echo (GRE) MRE‐derived stiffness estimations in various anatomical regions of the kidney. Kidney MRE was performed on 33 healthy subjects (8 for SE‐EPI MRE reproducibility and 25 for comparison with GRE MRE; age range: 22–66 years) in a 3 T MRI scanner. To demonstrate SE‐EPI MRE reproducibility, subjects were scanned for the first scan and then asked to leave the scan room and repositioned again for the second (repeat) scan. Similar set‐up was used for GRE MRE as well. The displacement data was then processed to obtain overall stiffness estimates of the kidney. Concordance correlation analyses were performed to determine SE‐EPI MRE reproducibility and agreement between GRE MRE and SE‐EPI MRE derived stiffness. A high concordance correlation (ρc = 0.95; p‐value<0.0001) was obtained for SE‐EPI MRE reproducibility. Good concordance correlation was observed (ρc = 0.84; p < 0.0001 for both kidneys, ρc = 0.91; p < 0.0001 for right kidney and ρc = 0.78; p < 0.0001 for left kidney) between GRE MRE and SE‐EPI MRE derived stiffness measurements. Paired t‐test results showed that stiffness value of medulla was significantly (p < 0.0001) greater than cortex using SE‐EPI MRE as well as GRE MRE. SE‐EPI MRE was reproducible and good agreement was observed in MRE‐derived stiffness measurements obtained using SE‐EPI and GRE sequences. Therefore, SE‐EPI can be used for kidney MRE applications.

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“…Furthermore, some conditions, e.g. inflammation, congestion, portal hypertension and cholestasis, can also cause increased liver stiffness [39]. Kim et al [40] illustrated in their recent paper that liver stiffness measured by MRE increases as cholestasis increases.…”

Section: Discussionmentioning

confidence: 99%

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

et al. 2018

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Objectives To assess if the administration of gadoxetate disodium (Gd-EOB-DTPA) significantly affects hepatic magnetic resonance elastography (MRE) measurements in the delayed hepatobiliary phase (DHBP). Methods A total of 47 patients (15 females, 32 males; age range 23-78 years, mean 54.28 years) were assigned to standard hepatic magnetic resonance imaging (MRI) with application of Gd-EOB-DTPA and hepatic MRE. MRE was performed before injection of Gd-EOB-DTPA and after 40-50 min in the DHBP. Liver stiffness values were obtained before and after contrast media application and differences between pre-and post-Gd-EOB-DTPA values were evaluated using a Bland-Altman plot and the Mann-Whitney-Wilcoxon test. In addition, the data were compared with regard to the resulting fibrosis classification. Results Mean hepatic stiffness for pre-Gd-EOB-DTPA measurements was 4.01 kPa and post-Gd-EOB-DTPA measurements yielded 3.95 kPa. We found a highly significant individual correlation between pre-and post-Gd-EOB-DTPA stiffness values (Pearson correlation coefficient of r = 0.95 (p < 0.001) with no significant difference between the two measurements (p =0.49)). Bland-Altman plot did not show a systematic effect for the difference between pre-and post-stiffness measurements (mean difference: 0.06 kPa, SD 0.81). Regarding the classification of fibrosis stages, the overall agreement was 87.23% and the intraclass correlation coefficient was 96.4%, indicating excellent agreement. Conclusions Administration of Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver in the DHBP. Therefore, MRE can be performed in the DHBP. Key Points • MRE of the liver can reliably be performed in the delayed hepatobiliary phase.• Gd-EOB-DTPA does not significantly influence MRE stiffness measurements of the liver.• MRE performed in the delayed hepatobiliary-phase is reasonable in patients with reduced liver function.

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Magnetic resonance elastography of liver and spleen: Methods and applications

Cited by 32 publications

References 180 publications

Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion

Magnetic resonance elastography‐derived stiffness of the kidneys and its correlation with water perfusion

Magnetic Resonance Elastography of kidneys: SE‐EPI MRE reproducibility and its comparison to GRE MRE

Does gadoxetate disodium affect MRE measurements in the delayed hepatobiliary phase?

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