“…Overall, SSI performed best for the detection of significant fibrosis, advanced fibrosis and cirrhosis (AUROCs for SSI, FibroScan™ and ARFI were 0.86, 0.82 and 0.77 for diagnoses of ≥ F2; 0.89, 0.86 and 0.84 for ≥ F3; and 0.88, 0.87 and 0.84 for F4; respectively) [45••]. The results are similar to prior individual studies [39,55]. It appears that none of the three imaging methods could accurately predict < F2 fibrosis, so further optimization of ultrasound techniques is needed [45••].…”