Magnetic resonance elastography for evaluation of renal parenchyma in chronic kidney disease: a pilot study

Han, Jun; Ahn, Jhii-Hyun; Kim, Jae‐Seok

doi:10.1007/s11547-020-01210-1

Cited by 17 publications

(22 citation statements)

References 30 publications

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“…Similar results were observed when comparing renal stiffness values obtained by MRE, which differentiated patients with CKD (5.10 kPa) from those with normally functioning kidneys (4.35 kPa). The mean stiffness in patients with CKD significantly increased from stage 1 to stage 4 148 . At stage 5 CKD (kidney failure) the renal stiffness decreased, likely due to renal hypoperfusion that can mask fibrosis 148 , 149 .…”

Section: Organ-specific Stiffnessmentioning

confidence: 97%

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Causal contributors to tissue stiffness and clinical relevance in urology

et al. 2021

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Mechanomedicine is an emerging field focused on characterizing mechanical changes in cells and tissues coupled with a specific disease. Understanding the mechanical cues that drive disease progression, and whether tissue stiffening can precede disease development, is crucial in order to define new mechanical biomarkers to improve and develop diagnostic and prognostic tools. Classically known stromal regulators, such as fibroblasts, and more recently acknowledged factors such as the microbiome and extracellular vesicles, play a crucial role in modifications to the stroma and extracellular matrix (ECM). These modifications ultimately lead to an alteration of the mechanical properties (stiffness) of the tissue, contributing to disease onset and progression. We describe here classic and emerging mediators of ECM remodeling, and discuss state-of-the-art studies characterizing mechanical fingerprints of urological diseases, showing a general trend between increased tissue stiffness and severity of disease. Finally, we point to the clinical potential of tissue stiffness as a diagnostic and prognostic factor in the urological field, as well as a possible target for new innovative drugs.

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Section: Organ-specific Stiffnessmentioning

confidence: 97%

“…The mean stiffness in patients with CKD significantly increased from stage 1 to stage 4 148 . At stage 5 CKD (kidney failure) the renal stiffness decreased, likely due to renal hypoperfusion that can mask fibrosis 148 , 149 . Furthermore, MRE was also evaluated for assessing the chronic renal allograft dysfunction.…”

Section: Organ-specific Stiffnessmentioning

confidence: 97%

Causal contributors to tissue stiffness and clinical relevance in urology

et al. 2021

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“…Functional MR data provide quantifiable information about underlying tissue characteristics [ 44 , 64 ]. The combination of objective biomarkers with morphologic data makes functional MRI a powerful tool that provides comprehensive information about lesion heterogeneity and therapy-induced changes in heterogeneity [ 28 , 85 , 86 ]. Functional MRI has additional potential in the early stages of treatment efficacy evaluation and should be useful in drug development [ 86 ].…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

“…The combination of objective biomarkers with morphologic data makes functional MRI a powerful tool that provides comprehensive information about lesion heterogeneity and therapy-induced changes in heterogeneity [ 28 , 85 , 86 ]. Functional MRI has additional potential in the early stages of treatment efficacy evaluation and should be useful in drug development [ 86 ]. Some functional analyses are already part of clinical practice: diffusion-weighted MRI (DW-MRI) and perfusion imaging (DCE-MRI) [ 13 , 45 , 68 ].…”

Section: Functional Magnetic Resonance Imagingmentioning

confidence: 99%

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

Bruno

Granata

Bellisari

et al. 2022

Cancers

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In the last decades, nanotechnology has been used in a wide range of biomedical applications, both diagnostic and therapeutic. In this scenario, imaging techniques represent a fundamental tool to obtain information about the properties of nanoconstructs and their interactions with the biological environment in preclinical and clinical settings. This paper reviews the state of the art of the application of magnetic resonance imaging in the field of nanomedicine, as well as the use of nanoparticles as diagnostic and therapeutic tools, especially in cancer, including the characteristics that hinder the use of nanoparticles in clinical practice.

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“…The most well-established clinical application of MRE is in the detection and quantification of hepatic fibrosis (29), with accurate and reliable results, as well as high intra-and interobserver agreement (30). Recently, applications for MRE have been extended to the detection of stiffness in the brain, lung, heart, kidney, spleen, and prostate tissues (31)(32)(33)(34)(35)(36). Many studies have examined the development of the MRE technique and its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Clinical studies of magnetic resonance elastography from 1995 to 2021: Scientometric and visualization analysis based on CiteSpace

Li¹,

Gao²,

Chen³

et al. 2022

Quant Imaging Med Surg

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In all, 1,236 articles published by 726 authors from 540 institutions in 40 countries were included in this study. The top 10 authors published 57.6% of all included articles. The 3 most productive countries were the USA (n=631), Germany (n=202), and France (n=134), and the 3 most productive institutions were the Mayo Clinic (n=240), Charité (n=131), and the University of Illinois (n=56). The USA and the Mayo Clinic had the highest betweenness centrality among countries and institutions, respectively, and played an important role in the field of MRE. In this study, the 24,347 distinct references were clustered into 48 categories via reasonable clustering using specific keywords, forming the knowledge framework. Among the 294 co-occurring keywords, "hepatic fibrosis", "stiffness", "skeletal muscle", "acoustic strain wave", "in vivo", and "non-invasive assessment" were research hotspots. "Diagnostic performance", "diagnostic accuracy", "hepatic steatosis", "chronic hepatitis B", "radiation force impulse", "children", and "echo" were frontier topics.Conclusions: Scientometric and visualized analysis of MRE can provide information regarding the knowledge framework, research hotspots, frontier areas, and emerging trends in this field.

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Magnetic resonance elastography for evaluation of renal parenchyma in chronic kidney disease: a pilot study

Cited by 17 publications

References 30 publications

Causal contributors to tissue stiffness and clinical relevance in urology

Causal contributors to tissue stiffness and clinical relevance in urology

Advanced Magnetic Resonance Imaging (MRI) Techniques: Technical Principles and Applications in Nanomedicine

Clinical studies of magnetic resonance elastography from 1995 to 2021: Scientometric and visualization analysis based on CiteSpace

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