A. Laquièr e · C. Boustièr e Mots clés P ancréatite aiguë idiopathique · Echo-endoscopie · Microlithiase vésiculaire · P ancréatite chronique · P ancréatite biliaire · Lithiase cholédocienne · P ancréas divisum · T umeur intracanalaire papillaire mucineuse du pancréas (TIPMP)Abstract In approximately 20% of patients with acute pancreatitis, a cause is not established by history, physical e xamination, routine laboratory testing or abdominal imaging. Recent studies suggest that microlithiasis is causati v e in up to 60% of patients with an unexplained acute pancreatitis (U AP) and g allbladder in situ. In the others, man y f actors play an etiological role in idiopathic pancreatitis, including pancreatic tumors, early chronic pancreatitis, pancreas divisum or annular pancreas, choledochocele, intraductal papillary mucinous tumours (IPMT), an anomalous pancreatobiliary junction or sphincter of Oddi dysfunction (SOD). The close proximity of the endoscopic ultrasound probe (EUS) to the pancreas and biliary tract results in superior spatial resolution compared with CT scan and MRI.The diagnostic yield of EUS in unexplained acute pancreatitis is 80%. EUS appears to be diagnostic in the majority of patients with pre viously unexplained pancreatitis and offers an alternati v e to MRI and endoscopic retrograde cholangiopancreatography (ERCP) as the initial diagnostic test in patients with unexplained acute pancreatitis. ARTICLE ORIGINAL © Springer -V erlag 2009 A. Laquière · C. Boustière ( ) Service d'hépato-gastroentérologie, Hôpital Saint Joseph, of U AP is 80%.Keywords Acute idiopathic pancreatitis · Endoscopic ultrasonography · Microlithiasis · Chronic pancreatitis · Biliary pancreatitis · Cholelithiasis · P ancreas divisum · Cholelithiasis · Choledocholithiasis · Intraductal papillary mucinous tumour (IPMT) · Biliary pancreatitis