Magnetic resonance angiography with hyperpolarized129Xe dissolved in a lipid emulsion

He, Möller; Ms, Chawla; Xj, Chen; Driehuys, Bastiaan; Hedlund, Laurence W.; Ct, Wheeler; Johnson, G. Allan

doi:10.1002/(sici)1522-2594(199905)41:5<1058::aid-mrm26>3.0.co;2-c

Cited by 49 publications

(7 citation statements)

References 28 publications

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“…LP 129 Xe is commonly produced by spin‐exchange optical pumping and exhibits a spin polarization which is several orders of magnitude higher than that of 129 Xe in thermal equilibrium, at common magnetic field strengths (5–25 T), and room temperature. Moreover, LP 129 Xe is increasingly applied in magnetic resonance imaging (MRI), for instance in lung and brain imaging11 and angiography 12. A major problem, however, is the dissolution of LP 129 Xe in aqueous solutions.…”

mentioning

confidence: 99%

NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

et al. 2006

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Go with the flow: In many applications of NMR spectroscopy in chemistry, proper sample preparation is absolutely critical for success, in particular in biochemical and biomedical areas. For the NMR spectroscopy of laser‐polarized 129Xe, an efficient and robust method for continuous flow of the gas to a NMR tube was developed. Applications to H2O, DMSO, phospholipid bicelles, and 2D exchange NMR spectroscopy are demonstrated.

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confidence: 99%

NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

et al. 2006

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“…Guinea pig lungs were studied in vivo to compare the NMR images obtained using hyperpolarised xenon and helium. 179,180 Helium allows acquisition of high-quality images at higher spatial resolution. 180 At the same time, xenon also has some advantages over helium.…”

Section: Hyperpolarised Gasesmentioning

confidence: 99%

“…185 Intrinsic exchange of xenon between erythrocytes and the plasma ± saline mixture has been studied. 185 Intravenous injection of xenon dissolved in a 30% soya oil-in-water emulsion into the tail of a living rat with simultaneous acquisition of MR angiograms of the abdominal and pelvic veins was used 186 for visualisation of the vascular system (MR angiography 2 ). This allowed selective imaging of relatively large veins and estimation of the velocity of blood flow through them.…”

Section: Hyperpolarised Gasesmentioning

confidence: 99%

Non-traditional applications of NMR tomography

Koptyug¹,

Sagdeev²

2003

Russ. Chem. Rev.

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“…For instance, HP 129 Xe can first be dissolved in a biologically compatible carrier and then injected directly into the vasculature [13]. When dissolved in saline, injected HP 129 Xe rapidly passes from the pulmonary capillaries into the alveolar airspaces [14] due to a combination of pulmonary perfusion and diffusive gas exchange [15], and its resonance frequency is shifted by ∼200 ppm, allowing 129 Xe residing in the airspaces to be selectively detected and imaged.…”

Section: Introductionmentioning

confidence: 99%

In Vivo MR Imaging of Pulmonary Perfusion and Gas Exchange in Rats via Continuous Extracorporeal Infusion of Hyperpolarized 129Xe

et al. 2012

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BackgroundHyperpolarized (HP) 129Xe magnetic resonance imaging (MRI) permits high resolution, regional visualization of pulmonary ventilation. Additionally, its reasonably high solubility (>10%) and large chemical shift range (>200 ppm) in tissues allow HP 129Xe to serve as a regional probe of pulmonary perfusion and gas transport, when introduced directly into the vasculature. In earlier work, vascular delivery was accomplished in rats by first dissolving HP 129Xe in a biologically compatible carrier solution, injecting the solution into the vasculature, and then detecting HP 129Xe as it emerged into the alveolar airspaces. Although easily implemented, this approach was constrained by the tolerable injection volume and the duration of the HP 129Xe signal.Methods and Principal FindingsHere, we overcome the volume and temporal constraints imposed by injection, by using hydrophobic, microporous, gas-exchange membranes to directly and continuously infuse 129Xe into the arterial blood of live rats with an extracorporeal (EC) circuit. The resulting gas-phase 129Xe signal is sufficient to generate diffusive gas exchange- and pulmonary perfusion-dependent, 3D MR images with a nominal resolution of 2×2×2 mm3. We also show that the 129Xe signal dynamics during EC infusion are well described by an analytical model that incorporates both mass transport into the blood and longitudinal relaxation.ConclusionsExtracorporeal infusion of HP 129Xe enables rapid, 3D MR imaging of rat lungs and, when combined with ventilation imaging, will permit spatially resolved studies of the ventilation-perfusion ratio in small animals. Moreover, EC infusion should allow 129Xe to be delivered elsewhere in the body and make possible functional and molecular imaging approaches that are currently not feasible using inhaled HP 129Xe.

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Magnetic resonance angiography with hyperpolarized129Xe dissolved in a lipid emulsion

Cited by 49 publications

References 28 publications

NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

Non-traditional applications of NMR tomography

In Vivo MR Imaging of Pulmonary Perfusion and Gas Exchange in Rats via Continuous Extracorporeal Infusion of Hyperpolarized 129Xe

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Magnetic resonance angiography with hyperpolarized129Xe dissolved in a lipid emulsion

Cited by 49 publications

References 28 publications

NMR Spectroscopy of Laser‐Polarized 129Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

NMR Spectroscopy of Laser‐Polarized 129Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

Non-traditional applications of NMR tomography

In Vivo MR Imaging of Pulmonary Perfusion and Gas Exchange in Rats via Continuous Extracorporeal Infusion of Hyperpolarized 129Xe

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Product

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NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules

NMR Spectroscopy of Laser‐Polarized ¹²⁹Xe Under Continuous Flow: A Method To Study Aqueous Solutions of Biomolecules