Magnetic resonance angiography imaging of pulmonary embolism using agents with blood pool properties as an alternative to computed tomography to avoid radiation exposure

Pressacco, Joséphine; Papas, Konstantin; Lambert, Jean; Finn, J. Paul; Desjardins, Alain; Irislimane, Yassin; Toporowicz, Kevin; Lanthier, Chantal; Samson, Paule; Desnoyers, Marcel; Maki, Jeffrey H.

doi:10.1016/j.ejrad.2019.02.007

Cited by 6 publications

(2 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the advantages of MRV, this technique may be considered as an alternative method for DVT assessment to duplex sonography. However, it is not feasible in patients with contraindications to gadolinium-contrast MR imaging, such as patients with renal insufficiency with an estimated glomerular filtration rate<30, pregnant women, those with a history of allergic reaction to gadolinium-based contrast material, critically ill patients who cannot tolerate MR scanning, claustrophobic patients or those unable to establish venous access, which is necessary for contrast-enhanced MRV (35). Moreover, compared with duplex sonography, MR examination has a relatively higher cost with the use of contrast material and a higher acoustic noise, and the main reason for the noise is related to mechanical vibrations of gradient coil during rapid switching of gradients (36).…”

Section: Discussionmentioning

confidence: 99%

Fat‑suppressed magnetic resonance volume interpolated examination for deep venous thrombosis compared with duplex sonography

Cheng

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

The aim of the present study was to evaluate magnetic resonance venography (MRV) scanned by breath-hold volume interpolated body examination with spectral fat saturation (VIBE-fs), combined with Dixon fat-suppressed VIBE (VIBE-Dixon) by using a 1.5T MR scanner for detecting deep venous thrombosis (DVT) compared with duplex sonography. A total of 31 patients with DVT were identified using duplex sonography and were enrolled in the present study for MRV examination, from the inferior vena cava to the ankle level after injection of gadopentetate dimeglumine. Venous segment-to-segment comparison was assessed for DVT detection between MRV and duplex sonography. A total of two radiologists separately performed subjective image quality assessment using a 5-point scale. Cohen's κ coefficient, Wilcoxon rank sum test and intraclass correlation coefficient values were used for statistical analysis. Of the 303 evaluated vein segments, duplex sonography identified 119 (39.3%; 119/303) venous segments with thrombus, while MRV detected 170 (56.1%; 170/303) venous segments with thrombus. The diagnostic agreement rate of DVT between duplex sonography and MRV was poor in the deep femoral vein and anterior tibial veins, while it was excellent in the inferior vena cava (IVC), common iliac vein, external iliac vein, femoral vein, popliteal vein, posterior tibial veins and peroneal veins. In addition, poor reliability was detected in the deep femoral vein, anterior tibial veins and peroneal veins, but good to excellent reliability was observed in IVC, common iliac vein, external iliac vein, femoral vein, popliteal vein and posterior tibial veins. Furthermore, image quality scores of each venous segment between the two radiologists indicated no statistical difference. Therefore, MRV scanned using VIBE-fs for the suprainguinal and VIBE-Dixon for the infrainguinal region may be a useful method for detecting DVT compared with duplex sonography. The results of present study proved this MR protocol to be a beneficial alternative imaging modality for the detection of DVT when duplex sonography is inadequate or not able to be performed.

show abstract

Section: Discussionmentioning

confidence: 99%

Fat‑suppressed magnetic resonance volume interpolated examination for deep venous thrombosis compared with duplex sonography

Cheng

et al. 2020

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Blood pool imaging (BPI) is widely used in preclinical and clinical research including the detection of gastrointestinal bleeding ( 1 ), blood volume measurement ( 2 ), evaluation of cardiac function ( 3 , 4 ), localization of hemangiomas ( 5 ), cerebral blood flow ( 6 , 7 ), detection of infection ( 8 ), or lymphoma ( 9 ). Various kinds of BPI agents have been developed, including 18 F-FDG-, 111 In-oxine ( 8 ), or 99m Tc-HMPAO-labeled leukocytes ( 10 ); 68 Ga-NOTA-NEB-( 9 ) and 111 In-oxine-labeled platelets ( 11 ); 99m Tc-PYP-labeled red blood cells (RBCs) ( 12 ); radionuclide-labeled peptides ( 13 ); and magnetic resonance angiography-based BPI agents ( 14 ). RBCs represent promising BPI agents due to their good stability and easy availability.…”

Section: Introductionmentioning

confidence: 99%

18F-PEG1-Vinyl Sulfone-Labeled Red Blood Cells as Positron Emission Tomography Agent to Image Intra-Abdominal Bleeding

Zhang

Wang

et al. 2021

Front. Med.

View full text Add to dashboard Cite

18F-Labeled blood pool agents (BPAs) have attracted great attention for identifying bleeding sites. However, many BPAs are not sufficiently evaluated partially due to the limitations of labeling methods. In our previous work, we noticed that 18F-PEG1-vinyl sulfone (18F-VS) could efficiently label red blood cells (RBCs) ex vivo and in situ. However, its application as BPA is not fully evaluated. In this study, we systematically explored the feasibility of using 18F-VS-labeled RBCs as a positron emission tomography (PET) BPA for intra-abdominal bleeding diagnosis. In brief, we first optimized the labeling conditions, which lead to an 80% labeling yield of RBCs after incubating with 18F-VS in phosphate-buffered saline (PBS) at 37°C for 20 min. 18F-VS-labeled RBCs were found to be stable in vitro, which could simplify its transportation/storage for in vivo applications. In normal rat PET study, the cardiovascular system could be clearly imaged up to 5 h post injection (p.i.). An intra-abdominal hemorrhage rat model demonstrated that the 18F-VS-labeled RBCs clearly showed the dynamic changes of extravascular radioactivity due to intra-abdominal hemorrhage. Validation in the model of gastrointestinal bleeding clearly demonstrated the great potential of using 18F-VS-labeled RBCs as a BPA, which could be further evaluated in future studies.

show abstract

Combined MR Imaging for Pulmonary Embolism and Deep Venous Thrombosis by Contrast-enhanced MR Volume Interpolated Body Examination

Dingxi

Kong

et al. 2020

CURR MED SCI

View full text Add to dashboard Cite

Magnetic resonance angiography imaging of pulmonary embolism using agents with blood pool properties as an alternative to computed tomography to avoid radiation exposure

Cited by 6 publications

References 46 publications

Fat‑suppressed magnetic resonance volume interpolated examination for deep venous thrombosis compared with duplex sonography

Fat‑suppressed magnetic resonance volume interpolated examination for deep venous thrombosis compared with duplex sonography

18F-PEG1-Vinyl Sulfone-Labeled Red Blood Cells as Positron Emission Tomography Agent to Image Intra-Abdominal Bleeding

Combined MR Imaging for Pulmonary Embolism and Deep Venous Thrombosis by Contrast-enhanced MR Volume Interpolated Body Examination

Contact Info

Product

Resources

About