Magnetic Resonance Angiography, Function and Viability Evaluation in Patients with Kawasaki Disease

Mavrogeni, Sophie; Papadopoulos, George; Douskou, Marouso; Kaklis, Savas; Seimenis, Ioannis; Varlamis, George; Karanasios, Evangelos; Krikos, Xenofon; Giannoulia, Aglaia; Cokkinos, Dennis V.

doi:10.1080/10976640600604773

Cited by 60 publications

(37 citation statements)

References 18 publications

(24 reference statements)

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“…12,23 A high accuracy of CMRI for measurement of the diameter and length of coronary aneurysms also has been reported previously. 11,[23][24][25] Suzuki et al 25 applied CMRI and echocardiography in a relatively large cohort of patients. Sixty-nine aneurysms were observed in 106 patients on echocardiography, and an additional 28 aneurysms were observed by CMRI.…”

Section: Cardiac Mrimentioning

confidence: 99%

“…However, previous studies have already reported excellent agreement between coronary angiography and CMRI for coronary artery evaluation. [11][12][13][14][22][23][24] Second, although we included patients in consecutive order of outpatient consultation, the study population contains a high percentage of patients with KD with CAAs compared with the literature of cardiovascular sequelae in KD (Ͻ10% CAA). This is explained by referral bias (ie, the more severe cases are being referred to a tertiary hospital).…”

Section: Limitationsmentioning

confidence: 99%

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Cardiac Magnetic Resonance Imaging for Noninvasive Assessment of Cardiovascular Disease During the Follow-Up of Patients With Kawasaki Disease

Tacke

Kuipers

Groenink

et al. 2011

Circ: Cardiovascular Imaging

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Background-Kawasaki disease (KD) is the most common cause of acquired coronary artery disease in childhood. In KD, the American Heart Association recommends echocardiography for routine coronary artery surveillance and nuclear perfusion scans and conventional coronary angiography in select patients. Cardiac MRI (CMRI) may be a noninvasive and radiation-free alternative. We applied CMRI during the follow-up of patients with KD and assessed the performance of CMRI compared with echocardiography. Methods and Results-Patients with KD aged Ն8 years were consecutively included. Sixty-three patients (median age, 14.6 years; 74.6% male sex) underwent a comprehensive CMRI protocol including adenosine stress testing to evaluate coronary artery anatomy, ischemia, and myocardial infarction. All patients underwent CMRI without significant complications. On CMRI, 23 coronary artery aneurysms (CAAs) were identified in 15 patients. CMRI detected thrombus formation in 6 CAAs in 4 patients, wall motion disturbances and ischemia in 4 patients, and delayed hyperenhancement indicating myocardial infarction in 5 patients. Wall motion and perfusion abnormalities were noted in territories supplied by affected coronary arteries. CMRI results were compared with recent echocardiography findings. In 6 of the 15 patients with CAAs on CMRI, CAAs were not detected by echocardiography. Conclusions-A comprehensive CMRI protocol including adenosine stress testing is feasible to identify coronary artery pathology, ischemia, and myocardial infarction in former patients with KD and compares favorably with echocardiography. CMRI may be used as a noninvasive and radiation-free imaging method for coronary artery surveillance during the long-term follow-up of patients with KD. (Circ Cardiovasc Imaging. 2011;4:712-720.)

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Section: Cardiac Mrimentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Cardiac Magnetic Resonance Imaging for Noninvasive Assessment of Cardiovascular Disease During the Follow-Up of Patients With Kawasaki Disease

Tacke

Kuipers

Groenink

et al. 2011

Circ: Cardiovascular Imaging

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show abstract

“…16 Prior CMRI studies in KD are limited and have focused mainly on the coronary artery sequelae. 26,[29][30][31][32] To date, 1 study by Mavrogeni et al 31 reported functional CMRI data of 20 patients with persistent CAAs. In all patients except 2 with prior myocardial infarction, the LVEF was found to be within normal values.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiac Function by Magnetic Resonance Imaging During the Follow-Up of Patients With Kawasaki Disease

Tacke

Romeih

Kuipers

et al. 2013

Circ: Cardiovascular Imaging

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Background-Although histopathologic studies suggest persistent myocardial abnormalities after Kawasaki disease (KD), the long-term effects on cardiac function remain to be revealed. We investigated biventricular volumes, function, and the presence of myocardial fibrosis by cardiac magnetic resonance imaging during long-term follow-up of KD. Methods and Results-Sixty patients with a history of KD (mean age, 16.9 years; 67% men; median interval after KD onset, 11.6 years) and 20 healthy control subjects (mean age, 17.9 years; 55% men) 12 to 24 years of age underwent cardiac magnetic resonance imaging. Biventricular end-diastolic volume, end-systolic volume, stroke volume, and ejection fraction were determined. Volumetric measurements were indexed for body surface area. Late contrast enhancement was used to detect areas of myocardial fibrosis. Biventricular volumes and function did not differ significantly between patients and control subjects. There were also no significant differences between patients with and without a history of left ventricular dysfunction resulting from KD-associated myocarditis or between patients with and without coronary artery aneurysms.Only those with prior ischemic heart disease had a significantly lower left ventricular ejection fraction compared with unaffected KD cases (left ventricular ejection fraction, 51% versus 57%; P=0.012). Late contrast enhancement was observed in only 2 patients with severe coronary artery aneurysms and was typical for myocardial infarction. Conclusions-In this cardiac magnetic resonance imaging study evaluating the cardiac function of patients with KD at longterm follow-up, we did not observe a difference in cardiac function between KD patients and control subjects, except for a subgroup of patients with ischemic heart disease as a result of severe coronary artery pathology.

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“…However, radiation exposure in children is still a main limitation to the clinical use of this technique for the follow-up of the disease. Cardiac MRI MRI has good soft-tissue contrast and today is an interesting noninvasive technique for the evaluation of coronary arteries, myocardial perfusion and left ventricular function (Post et al 1995;Mavrogeni et al 2006;Greil et al 2002;Fujiwara et al 2001).…”

Section: Mdct Coronary Angiographymentioning

confidence: 99%

Imaging of Kawasaki Disease

Askri

Hendaoui

Mechmèche

et al. 2011

Systemic Vasculitis

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Magnetic Resonance Angiography, Function and Viability Evaluation in Patients with Kawasaki Disease

Abstract: In Kawasaki disease MRA, SSFP cine and ceCMR are able to perform noninvasive coronary artery evaluation, function and infarct detection in a single study.

Cited by 60 publications

References 18 publications

Cardiac Magnetic Resonance Imaging for Noninvasive Assessment of Cardiovascular Disease During the Follow-Up of Patients With Kawasaki Disease

Cardiac Magnetic Resonance Imaging for Noninvasive Assessment of Cardiovascular Disease During the Follow-Up of Patients With Kawasaki Disease

Evaluation of Cardiac Function by Magnetic Resonance Imaging During the Follow-Up of Patients With Kawasaki Disease

Imaging of Kawasaki Disease

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