Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal

Bunck, Alexander C.; Kröger, Jan-Robert; Jüttner, Alena; Brentrup, Angela; Fiedler, Barbara; Schaarschmidt, Frank; Crelier, Gérard; Schwindt, Wolfram; Heindel, Walter; Niederstadt, Thomas; Maintz, David

doi:10.1007/s00330-011-2105-7

Cited by 74 publications

(91 citation statements)

References 25 publications

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“…These studies demonstrated the applicability and usefulness of this technique. In an interesting study by Bunck et al [38] the authors evaluated the usefulness of MR velocity mapping in the assessment of CSF dynamics in healthy volunteers and patients with lesions at the craniocervical junction or the cervical spinal canal. They found that CSF flow in healthy volunteers was homogeneously distributed in the anterior and anterolateral subarachnoid space, whereas patients showed grossly altered CSF flow patterns with formation of flow jets and increased flow velocities.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results

et al. 2011

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results

et al. 2011

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“…Recently, time-resolved 3D phase-contrast or 4-dimensional (4D) velocity mapping (4D-VM) techniques have been applied to the ventricular system 21,22 and craniocervical junction 23 to analyze spatiotemporal CSF hydrodynamics in an extensive field. Stadlbauer and associates have classified CSF dynamics on the basis of velocity mapping in the ventricular system.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

et al. 2015

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Purpose: We compared the depiction of pulsatile CSF motion obtained by 4-dimensional phase-contrast velocity mapping (4D-VM) with that by time-spatial labeling inversion pulse (time-SLIP) technique in the presence of membrane structures.Materials and Methods: We compared the 2 techniques using a flow phantom comprising tubes with and without a thin rubber membrane and applied the techniques to 6 healthy volunteers and 2 patients to analyze CSF dynamics surrounding thin membrane structures, such as the Liliequist membrane (LM), or the wall of an arachnoid cyst.Results: Phantom images exhibited propagation of the flow and pressure gradient beyond the membrane in the tube. In contrast, fluid labeled by the time-SLIP technique showed little displacement from the blockage of spin travelling by the membrane. A similar phenomenon was observed around the LM in healthy volunteers and the arachnoid cyst wall in a patient.Conclusion: Four-dimensional phase-contrast velocity mapping permitted visualization of the propagation of CSF pulsation through the intracranial membranous structures. This suggests that 4D-VM and the time-SLIP technique provide different information on flow and that both techniques are useful for classifying the pathophysiological status of CSF and elucidating the propagation pathway of CSF pulsation in the cranium.

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“…At present, MRI techniques are being developed to measure CSF pressure gradients noninvasively [14], but these methods are not in standard use and have not been validated. In principle, changes in CSF pressure gradients are related to alterations in impedance to CSF motion, CSF velocities [15][16][17][18][19][20][21][22], neural tissue motion [23][24][25], and craniospinal compliance [26][27][28]. We suspect that alterations in each of these biomechanical parameters could prove useful to quantify the biomechanical environment near the CVJ in CMI.…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal Fluid Flow Impedance is Elevated in Type I Chiari Malformation

Shaffer

Martin

Rocque

et al. 2014

Journal of Biomechanical Engineering

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Diagnosis of Type I Chiari malformation (CMI) is difficult because the most commonly used diagnostic criterion, cerebellar tonsillar herniation (CTH) greater than 3-5 mm past the foramen magnum, has been found to have little correlation with patient symptom severity. Thus, there is a need to identify new objective measurement(s) to help quantify CMI severity. This study investigated longitudinal impedance (LI) as a parameter to assess CMI in terms of impedance to cerebrospinal fluid motion near the craniovertebral junction. LI was assessed in CMI patients (N ¼ 15) and age-matched healthy controls (N ¼ 8) using computational fluid dynamics based on subject-specific magnetic resonance imaging (MRI) measurements of the cervical spinal subarachnoid space. In addition, CTH was measured for each subject. Mean LI in the CMI group (551 6 66 dyn/cm 5 ) was significantly higher than in controls (220 6 17 dyn/cm 5 , p < 0.001). Mean CTH in the CMI group was 9.0 6 1.1 mm compared to À0.4 6 0.5 mm in controls. Regression analysis of LI versus CTH found a weak relationship (R 2 ¼ 0.46, p < 0.001), demonstrating that CTH was not a good indicator of the impedance to CSF motion caused by cerebellar herniation. These results showed that CSF flow impedance was elevated in CMI patients and that LI provides different information than a standard CTH measurement. Further research is necessary to determine if LI can be useful in CMI patient diagnosis.

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Magnetic resonance 4D flow characteristics of cerebrospinal fluid at the craniocervical junction and the cervical spinal canal

Abstract: 4D PC MR imaging allows for a detailed assessment of CSF flow dynamics helping to distinguish physiological from complex pathological flow patterns at the craniocervical junction and the cervical spine.

Cited by 74 publications

References 25 publications

Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results

Magnetic resonance velocity mapping of 3D cerebrospinal fluid flow dynamics in hydrocephalus: preliminary results

Visualization of Pulsatile CSF Motion Around Membrane-like Structures with both 4D Velocity Mapping and Time-SLIP Technique

Cerebrospinal Fluid Flow Impedance is Elevated in Type I Chiari Malformation

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