Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe5C2@Fe3O4 Nanoparticles

Yu, Jing; Zhao, Fan; Gao, Weiliang; Yang, Xue; Ju, Yanmin; Zhao, Lingyun; Guo, Weisheng; Xie, Jun; Liang, Xing‐Jie; Tao, Xin; Li, Juan; Ying, Yao; Li, Wangchang; Zheng, Jingwu; Qiao, Liang; Xiong, Sheng; Mou, Xiaozhou; Che, Shenglei; Hou, Yanglong

doi:10.1021/acsnano.9b01740

Cited by 141 publications

(96 citation statements)

References 54 publications

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“…ROS-mediated destruction of tumor cells is a key mechanism for PDT, SDT, and radiotherapy [ 62 , 63 ]. However, as discussed above, ROS generation is inherently ineffective in the hypoxic regions of tumors [ 64 ].…”

Section: Resultsmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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Sonodynamic therapy (SDT) has emerged as an important modality for cancer treatment. SDT utilizes ultrasound excitation, which overcomes the limitations of light penetration in deep tumors, as encountered by photodynamic therapy (PDT) which uses optical excitations. A comparative study of these modalities using the same sensitizer drug can provide an assessment of their effects. However, the efficiency of SDT and PDT is low in a hypoxic tumor environment, which limits their applications. In this study, we report a hierarchical nanoformulation which contains a Food and Drug Administration (FDA) approved sensitizer chlorin, e6, and a uniquely stable high loading capacity oxygen carrier, perfluoropolyether. This oxygen carrier possesses no measurable cytotoxicity. It delivers oxygen to overcome hypoxia, and at the same time, boosts the efficiency of both SDT and PDT. Moreover, we comparatively analyzed the efficiency of SDT and PDT for tumor treatment throughout the depth of the tissue. Our study demonstrates that the strengths of PDT and SDT could be combined into a single multifunctional nanoplatform, which works well in the hypoxia environment and overcomes the limitations of each modality. The combination of deep tissue penetration by ultrasound and high spatial activation by light for selective treatment of single cells will significantly enhance the scope for therapeutic applications.

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Section: Resultsmentioning

confidence: 99%

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

et al. 2020

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“…Due to its special Fenton reaction, Fe nanoparticles can produce reactive •OH species with endogenous H 2 O 2 (Fe 2+ + H 2 O 2 → Fe 3+ + •OH + OH −) and produce cytotoxic effects without external energy through chemotherapeutic therapy (CDT). Yu et al fabricated a core–shell structured iron-based NPs (Fe 5 C 2 @Fe 3 O 4 ) to release ferrous ions in acidic environments to disproportionate H 2 O 2 into •OH radicals, and its high magnetization is favorable for both magnetic targeting and T2-weighted MRI [ 147 ]. In addition, gold nanospheres, graphene oxide, polydopamine (PDA), and other materials have been widely used as PTT reagents and nano carriers to deliver PDT reagents, so as to overcome the therapeutic limitations of PDT [ 148 , 149 , 150 ].…”

Section: Microenvironment-targeted Nano-delivery System As a Promising Strategymentioning

confidence: 99%

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Sun

Shi

et al. 2021

Molecules

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Recent findings suggest that tumor microenvironment (TME) plays an important regulatory role in the occurrence, proliferation, and metastasis of tumors. Different from normal tissue, the condition around tumor significantly altered, including immune infiltration, compact extracellular matrix, new vasculatures, abundant enzyme, acidic pH value, and hypoxia. Increasingly, researchers focused on targeting TME to prevent tumor development and metastasis. With the development of nanotechnology and the deep research on the tumor environment, stimulation-responsive intelligent nanostructures designed based on TME have attracted much attention in the anti-tumor drug delivery system. TME-targeted nano therapeutics can regulate the distribution of drugs in the body, specifically increase the concentration of drugs in the tumor site, so as to enhance the efficacy and reduce adverse reactions, can utilize particular conditions of TME to improve the effect of tumor therapy. This paper summarizes the major components and characteristics of TME, discusses the principles and strategies of relevant nano-architectures targeting TME for the treatment and diagnosis systematically.

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“…Hou et al developed a pH-sensitive nanoreactor based on core-shell-structured iron carbide nanoparticles with amorphous Fe 3 O 4 shells (Fe 5 C 2 @Fe 3 O 4 ). The amorphous Fe 3 O 4 shells were less stable against dissolution and able to release ferrous ions in acidic environments to generate •OH through the Fenton reaction of H 2 O 2 , effectively inhibiting the proliferation of tumor cells (Yu et al, 2019).…”

Section: Intrinsic Fenton Reaction Of Ferritementioning

confidence: 99%

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

Zhang

et al. 2021

Front. Chem.

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Ferrite nanoparticles have been widely used in the biomedical field (such as magnetic targeting, magnetic resonance imaging, magnetic hyperthermia, etc.) due to their appealing magnetic properties. In tumor acidic microenvironment, ferrite nanoparticles show intrinsic peroxidase-like activities, which can catalyze the Fenton reaction of hydrogen peroxide (H2O2) to produce highly toxic hydroxyl free radicals (•OH), causing the death of tumor cell. Recent progresses in this field have shown that the enzymatic activity of ferrite can be improved via converting external field energy such as alternating magnetic field and near-infrared laser into nanoscale heat to produce more •OH, enhancing the killing effect on tumor cells. On the other hand, combined with other nanomaterials or drugs for cascade reactions, the production of reactive oxygen species (ROS) can also be increased to obtain more efficient cancer therapy. In this review, we will discuss the current status and progress of the application of ferrite nanoparticles in ROS-mediated cancer therapy and try to provide new ideas for this area.

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Magnetic Reactive Oxygen Species Nanoreactor for Switchable Magnetic Resonance Imaging Guided Cancer Therapy Based on pH-Sensitive Fe₅C₂@Fe₃O₄ Nanoparticles

Cited by 141 publications

References 54 publications

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Perfluoropolyether Nanoemulsion Encapsulating Chlorin e6 for Sonodynamic and Photodynamic Therapy of Hypoxic Tumor

Exploiting a New Approach to Destroy the Barrier of Tumor Microenvironment: Nano-Architecture Delivery Systems

Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy

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