Mn3Sn is a fascinating magnetic topological system, showing topological characteristics within the Kagome lattice network due to the non-vanishing Berry phase in the momentum space. In this study, for the first time, we show a large pure roomtemperature topological Hall effect (THE) in the xy-plane (0001), while the anomalous Hall effect (AHE) has been noticed in the zx-plane (01 10) of Mn3Sn. With Fe doping, we can induce a giant xy-plane THE in addition to AHE at low temperatures, while still preserving the pure room-temperature THE in Mn2.8Fe0.2Sn. Moreover, the AHE in the zx-plane has been increased with Fe doping. Our studies indicate that the topological properties are highly anisotropic in these systems. Most importantly, the large room-temperature pure THE observed in Mn3Sn is quite promising for the realization of room-temperature topotronic-based applications.