Magnetic polyamidoamine dendrimers for magnetic separation and sensitive determination of organochlorine pesticides from water samples by high-performance liquid chromatography

Zhou, Qingxiang; Wu, Yiping; Sun, Yong; Sheng, Xueying; Tong, Yayan; Guo, Jinghan; Zhou, Boyao; Zhao, Jingyi

doi:10.1016/j.jes.2020.09.005

Cited by 39 publications

(8 citation statements)

References 36 publications

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“…These XRD patterns confirm that the material structure has a cubic spinel phase (Fig. 3a-c) 35 and match with the standard Fe 3 O 4 sample (JCPDS file No. 19-0629) 36 .…”

Section: Resultssupporting

confidence: 78%

Magnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery

Ahangarani-Farahani

Bodaghifard

Asadbegi

2022

Sci Rep

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Nanoscale engineering is an efficient method for the treatment of multiple infectious diseases. Due to the controllable functionalities, surface properties, and internal cavities, dendrimer-based nanoparticles represent high performance in drug delivery, making their application attractive in pharmaceutical and medicinal chemistry. In this study, a dendritic nanostructure (Fe3O4@SiO2@TAD-G3) was designed and fabricated by grafting a triazine-based dendrimer on a magnetic nanomaterial. The structure of synthesized hybrid nanostructure was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), and vibrating sample magnetometry (VSM). The prepared nanostructure (Fe3O4@SiO2@TAD-G3) combines the unique properties of magnetic nanoparticles and a hyperbranched dendrimer for biomedical applications. Its dual nature and highly exposed active sites, could make the transportation of drugs to targeted sites of interest through the magnetic field. A study was conducted on model drugs loading (Favipiravir and Zidovudine) and in vitro release behaviour of Fe3O4@SiO2@TAD-G3, which was monitored by ultraviolet spectroscopy. The dendritic nanostructure exhibited high drug-loading capacity for Favipiravir (63.2%) and Zidovudine (76.5%). About (90.8% and 80.2%) and (95.5% and 83.4%) of loaded Favipiravir and Zidovudine were released from Fe3O4@SiO2@TAD-G3 at pH 1.5 and 6.8 respectively, within 600 min and at 37 °C. The initial fast release attributed to the drug molecules on the surface of nanostructure while the drugs incorporated deeply into the pores of the Fe3O4@SiO2@TAD-G3 released with a delay. We proposed that Fe3O4@SiO2@TAD-G3 could be tested as an effective carrier in the targeted (cellular or tissue) delivery of drugs. We think that the prepared nanostructure will not deposit in the liver and lungs due to the small size of the nanoparticles.

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“…These XRD patterns confirm that the material structure has a cubic spinel phase (Fig. 3a-c) 35 and match with the standard Fe 3 O 4 sample (JCPDS file No. 19-0629) 36 .…”

Section: Resultssupporting

confidence: 78%

Magnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery

Ahangarani-Farahani

Bodaghifard

Asadbegi

2022

Sci Rep

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“…Organochlorine and organophosphorus group of pesticides are extensively used to combat crop pests and vector-borne diseases. Therefore, these two groups have been considered a key environmental concern due to its persistency and subsequent harmfulness ( Samare et al., 2020 ; Zhou et al., 2021 ). Due to their deleterious effect on the environment and members of the food chain or food web, many pesticides have been prohibited or banned to use in many country including India ( Lan et al., 2019 ; Sah et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Zeyad

Khan

Malik

2022

Heliyon

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“…Organochlorine and organophosphorus group of pesticides are extensively used to combat crop pests and vector-borne diseases. Therefore, these two groups have been considered a key environmental concern due to its persistency and subsequent harmfulness 56,57 Due to their deleterious effect on the environment and members of the food chain or food web, many pesticides have been prohibited or banned to use in many country including India 58,59 . The concentration of organochlorine pesticides like α-BHC, β-BHC, lindane, heptachlor, aldrin, α-endosulfan, 4-4" DDE, dieldrin, β-endosulfan, endrin aldehyde, endosulfan sulfate and endrin ketone in wastewater irrigated soils were 31.…”

Section: Discussionmentioning

confidence: 99%

Genotoxic Hazard and Oxidative Stress Induced by Wastewater Irrigated Soil With Special Reference to Pesticides and Heavy Metal Pollution

Zeyad

Malik

2021

Preprint

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Enhancement of industrial growth and urbanization, soil contamination is increasingly prominent. Therefore, it’s important to examine possible adverse effects of industrial waste. Samples were found to be polluted with several heavy-metals and pesticides. Gas chromatographic results showed occurrence of high-level of organochlorine and organophosphate pesticides. Genotoxicity of soil extracts was assessed using environmental-risk assessment models. Soil samples were extracted in hexane and dichloromethane solvents and were evaluated for genotoxic potential by prokaryotic (Ames test, plasmid nicking assay and E. coli K-12 DNA repair defective mutants) and eukaryotic (Allium cepa root chromosomal aberration and Vigna radiata seed-germination test) bioassays. Strain TA98 was found most susceptible among soil extracts. Hexane soil extract of wastewater irrigation was determined more mutagenic than DCM samples in terms of mutagenic index, mutagenic potential and induction factor for Ames strains. The damage in DNA repair defective mutants of hexane extracts were found higher compared to DCM extracts at dose of 20 μl/ml of culture. Survival in polA, lexA and recA mutants were 39%, 47% and 55% while treated with hexane extract. Allium cepa test, mitotic index was decreased in dose-dependent way and various kinds of chromosomal aberrations were found. Vigna radiata seeds germination and other parameters were also affected when treated with contaminated soil. Oxidative stress in V. radiata roots were also showed under CLS microscope. Genotoxicity of contaminated soil extract was also confirmed by plasmid nicking test. Our study provides possible explanation for the assessment of potential health and environmental hazards of the industrial region.

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Magnetic polyamidoamine dendrimers for magnetic separation and sensitive determination of organochlorine pesticides from water samples by high-performance liquid chromatography

Cited by 39 publications

References 36 publications

Magnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery

Magnetic triazine-based dendrimer as a versatile nanocarrier for efficient antiviral drugs delivery

Genotoxic hazard and oxidative stress induced by wastewater irrigated soil with special reference to pesticides and heavy metal pollution

Genotoxic Hazard and Oxidative Stress Induced by Wastewater Irrigated Soil With Special Reference to Pesticides and Heavy Metal Pollution

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