Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin

Pourjavadi, Ali; Hosseini, Seyed Hasan; Alizadeh, Mahshid; Bennett, Craig

doi:10.1016/j.colsurfb.2013.12.048

Cited by 47 publications

(27 citation statements)

References 32 publications

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“…Several functional groups can potentially be incorporated into the structural components that make up pH-responsive systems such as but not limited to carboxyl [ 90 ], amine [ 91 ], and Schiff base [ 92 ].…”

Section: Stimuli-responsive Magnetic Nanoparticlesmentioning

confidence: 99%

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

Hosseini

Farjadian

Makhlouf

2016

Industrial Applications for Intelligent Polymers and Coatings

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The evolution in the synthesis of smart polymers broadens new horizons for their potent application in medicine, especially in drug delivery. Many synthetic polymers that exhibit environmentally responsive behavior are potential smart carrier candidates that allow for controlled therapeutic delivery. These materials can be loaded with specifi c drugs for therapeutic applications, releasing treatment in response to a stimulus. This stimuli-responsive capability has enabled smart polymeric materials to distribute drugs in response to commonly known exogenous and/ or endogenous stimuli. Examples of these various stimuli include pH, enzyme concentration, temperature, ultrasound intensity, as well as light, magnetic fi eld, redox gradients and a multitude of other potential stimuli. This chapter provides a detailed critical discussion and an overview of the stimuli-responsive polymers which have found applications in targeted drug delivery. Furthermore, multiresponsive systems and their forthcoming development as well as challenges associated with some stimuli-responsive systems are discussed. Finally, the most recent and emerging trends along with a look toward expected future breakthroughs using these types of nanocarriers are discussed.

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Section: Stimuli-responsive Magnetic Nanoparticlesmentioning

confidence: 99%

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

Hosseini

Farjadian

Makhlouf

2016

Industrial Applications for Intelligent Polymers and Coatings

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“…The final mixture was neutralized by Na 2 CO 3 and purified by alumina column chromatography and methanol as an eluent. Methanol was evaporated using rotary evaporator [29]. For the preparation of PEGylated dend r i t i c n a n o p a r t i c l e s , 0 .…”

Section: Preparation Of Pegylated Dendritic Nanoparticlesmentioning

confidence: 99%

Folate-Conjugated pH-Responsive Nanocarrier Designed for Active Tumor Targeting and Controlled Release of Gemcitabine

2015

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“…158, 162-165 Figure 11 illustrate hybrid nanomaterials modified with PAMAM dendrimer. Functionalization of magnetic nanoparticles by dendritic 15 polymers/copolymers has been considered as the most promising way to reduce their toxicity, enhance biocompatibility and water solubility and modify them for preparation of magnetic-targetable drug carriers 166,167 . Chang et al 138 synthesized a water-soluble and pH-responsive anticancer drug carriers consist of DOX-20 PAMAM conjugates attached to the surface of superparamagnetic iron oxide nanoparticles (Fig.…”

Section: Polyamidoamine (Pamam) Dendrimermentioning

confidence: 99%

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

2015

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Despite immense investigations in the field of cancer diagnosis and therapy in recent decades, cancer is still the major cause of morbidity and mortality all over the world. Recently, with the advancement of nanotechnology, designing and preparation of efficient nano-sized structures having the potential of diagnosis and treatment of cancer have been proposed. Among different types of nano-sized materials, biocompatible polymers are seemed to be innovative tools with huge potential in cancer treatment. Advancement in polymer chemistry 10 55 gene delivery 2-7 , cancer diagnosis and therapy 8-11 , nanocarriers 12, 13 , nanomedicine 14-16 , and biomedical applications.

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Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin

Cited by 47 publications

References 32 publications

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

Smart Stimuli-Responsive Nano-sized Hosts for Drug Delivery

Folate-Conjugated pH-Responsive Nanocarrier Designed for Active Tumor Targeting and Controlled Release of Gemcitabine

Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems

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