Magnetic particles: From preparation to lab-on-a-chip, biosensors, microsystems and microfluidics applications

Jamshaid, Talha; Tenório‐Neto, Ernandes T.; Eissa, Mohamed M.; Zine, Nadia; Kunita, Marcos H.; El-Salhi, Abdelhamid Errachid; Elaı̈ssari, Abdelhamid

doi:10.1016/j.trac.2015.10.022

Cited by 104 publications

(69 citation statements)

References 125 publications

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“…The vision beyond the development of LOC platforms is to integrate common laboratory functions into one single chip within an area of only a few square centimeters with the aptitude to identify toxins, biochemical products, or disease symptoms, and allow biological screening essays or targeted drug delivery . Moreover, they demonstrated the potential and ability to be applied in a wide range of other technological applications beyond healthcare involving environmental monitoring, food, agriculture, and biochemical research . LOC term is often indicated in the literature as an alternative name for Micro Total Analysis Systems or even microfluidic systems.…”

Section: Representative Biomedical Applicationsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

525

330

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Magnetic nanoparticles (NPs) are emerging as an important class of biomedical functional nanomaterials in areas such as hyperthermia, drug release, tissue engineering, theranostic, and lab-on-a-chip, due to their exclusive chemical and physical properties. Although some works can be found reviewing the main application of magnetic NPs in the area of biomedical engineering, recent and intense progress on magnetic nanoparticle research, from synthesis to surface functionalization strategies, demands for a work that includes, summarizes, and debates current directions and ongoing advancements in this research field. Thus, the present work addresses the structure, synthesis, properties, and the incorporation of magnetic NPs in nanocomposites, highlighting the most relevant effects of the synthesis on the magnetic and structural properties of the magnetic NPs and how these effects limit their utilization in the biomedical area. Furthermore, this review next focuses on the application of magnetic NPs on the biomedical field. Finally, a discussion of the main challenges and an outlook of the future developments in the use of magnetic NPs for advanced biomedical applications are critically provided.

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Section: Representative Biomedical Applicationsmentioning

confidence: 99%

Advances in Magnetic Nanoparticles for Biomedical Applications

Cardoso

Francesko

Ribeiro

et al. 2017

Adv Healthcare Materials

525

330

View full text Add to dashboard Cite

show abstract

“…There are several reviews and book chapters describing the advances and applications of MNPs [17][18][19][20][21][22][23][24][25]; this paper aims to summarize and underline the latest findings in the field focusing on synthesis, functionalization and application of MNPs in cancer biomedicine. Cancer detection, screening and treatment within the MNPs use is presented starting with biosensing technologies, followed by the visualization of tumors within imaging techniques and the treatment of tumors through targeted delivery approaches, and lastly by hyperthermia and photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

2019

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During the last few decades, magnetic nanoparticles have been evaluated as promising materials in the field of cancer detection, screening, and treatment. Early diagnosis and screening of cancer may be achieved using magnetic nanoparticles either within the magnetic resonance imaging technique and/or sensing systems. These sensors are designed to selectively detect specific biomarkers, compounds that can be related to the onset or evolution of cancer, during and after the treatment of this widespread disease. Some of the particular properties of magnetic nanoparticles are extensively exploited in cancer therapy as drug delivery agents to selectively target the envisaged location by tailored in vivo manipulation using an external magnetic field. Furthermore, individualized treatment with antineoplastic drugs may be combined with magnetic resonance imaging to achieve an efficient therapy. This review summarizes the studies about the implications of magnetic nanoparticles in cancer diagnosis, treatment and drug delivery as well as prospects for future development and challenges of magnetic nanoparticles in the field of oncology.

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“…Magnetic colloidal particle suspensions have been used to study a wealth of physical phenomena which span from fundamental aspects to application‐oriented topics, e.g., in medical science and imaging, in microfluidic sensing, or in environmental engineering . Recent examples address directed motion in anisotropic media or along chemical, thermal, and magnetic field gradients, the pattern formation under static and dynamic external field conditions with applied shear forces, or in conjunction with magnetic frustration, as well as applications as bit‐patterned magnetic media, ferrofluids, magnetically directed or actuated swimmers, or microscale motors .…”

Section: Introductionmentioning

confidence: 99%

A Two‐Parameter Model for Colloidal Particles with an Extended Magnetic Cap

Neumann

Strobel

Alsaadawi

et al. 2019

Physica Status Solidi (a)

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Self-assembly of magnetic colloidal particles in solution has successfully been simulated by hard-or soft-sphere models with a set of embedded magnetic point dipoles, and the position and orientation of each dipole are adapted to mimic the magnetization distribution. Herein, a conceptually simpler approach is introduced for magnetically capped colloidal particles, which replaces the set of dipoles by the extended magnetization distribution of a single conductive loop. Only two parameters are required to characterize the magnetization distribution: the diameter of the loop and its radial off-center shift within the sphere. This approach reflects the radial symmetry and the spatial extension of the magnetic cap. At larger distance and in the limit of very small loops that model reproduces the far field and particle arrangements obtained with the single, radially shifted dipole model. For larger loop radii, additional stable assembly patterns are obtained, which occur in experiments, but cannot be simulated with a single shifted dipole model.

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Magnetic particles: From preparation to lab-on-a-chip, biosensors, microsystems and microfluidics applications

Cited by 104 publications

References 125 publications

Advances in Magnetic Nanoparticles for Biomedical Applications

Advances in Magnetic Nanoparticles for Biomedical Applications

Implication of Magnetic Nanoparticles in Cancer Detection, Screening and Treatment

A Two‐Parameter Model for Colloidal Particles with an Extended Magnetic Cap

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