Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Chandrasekharan, Prashant; Kuo, Renesmee; Fung, K. L. Barry; Saayujya, Chinmoy; Bryan, Jacob; Yousuf, Mariam; Fellows, Benjamin D.; Colson, Caylin; Huynh, Quincy; Doyle, Owen; Hartley, Allison; Yousuf, Khadija; Goodwill, Patrick; Conolly, Steven M.

doi:10.1155/2023/4131117

Cited by 6 publications

(3 citation statements)

References 145 publications

(218 reference statements)

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“…Since its development by Gleich and Weizenecker in 2005 [80], rapid advancements have been achieved in hardware innovation, magnetic field generation, signal detection, image acquisition and reconstruction strategies, tracer development, and preclinical translational research [81][82][83][84]. Currently, MPI demonstrates immense potential across various biomedical applications, including theranostics, drug delivery, magnetofluid hyperthermia, cell tracking, and perfusion imaging [85][86][87], progressively establishing its pivotal role in advancing preclinical and translational research in the biomedical imaging domain. Within this field, the design and engineering of SPIOs for use in MRI, MPI, and multimodal imaging contrast agents have become central to technological advancements.…”

Section: Magnetic Particle Imaging (Mpi) Is An Emerging Non-invasive ...mentioning

confidence: 99%

Elucidating Iron Metabolism through Molecular Imaging

Liao,

Yang,

Long

et al. 2024

CIMB

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Iron is essential for many physiological processes, and the dysregulation of its metabolism is implicated in the pathogenesis of various diseases. Recent advances in iron metabolism research have revealed multiple complex pathways critical for maintaining iron homeostasis. Molecular imaging, an interdisciplinary imaging technique, has shown considerable promise in advancing research on iron metabolism. Here, we comprehensively review the multifaceted roles of iron at the cellular and systemic levels (along with the complex regulatory mechanisms of iron metabolism), elucidate appropriate imaging methods, and summarize their utility and fundamental principles in diagnosing and treating diseases related to iron metabolism. Utilizing molecular imaging technology to deeply understand the complexities of iron metabolism and its critical role in physiological and pathological processes offers new possibilities for early disease diagnosis, treatment monitoring, and the development of novel therapies. Despite technological limitations and the need to ensure the biological relevance and clinical applicability of imaging results, molecular imaging technology’s potential to reveal the iron metabolic process is unparalleled, providing new insights into the link between iron metabolism abnormalities and various diseases.

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Section: Magnetic Particle Imaging (Mpi) Is An Emerging Non-invasive ...mentioning

confidence: 99%

Elucidating Iron Metabolism through Molecular Imaging

Liao,

Yang,

Long

et al. 2024

CIMB

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“…In another way, MPI is primarily concerned with visualising and analysing the movement and distribution of magnetic nanoparticles within the body. By utilising these magnetic tracers, MPI enables the detection and monitoring of specific targets or processes, such as the localisation of certain cells or the assessment of blood flow dynamics [10]. It offers unique capabilities in terms of real-time imaging, high sensitivity, and quantitative analysis of magnetic particles, making it a valuable tool for a wide range of applications, including biomedical research and diagnostics.…”

Section: Introductionmentioning

confidence: 99%

Advancement of magnetic particle imaging in diagnosis and therapy

Harini,

Girigoswami,

Pallavi

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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Magnetic particle imaging (MPI) has gained significant traction as an ionising radiation-free tomographic method that offers real-time imaging capabilities with enhanced sensitivity and resolutions. In this technique, magnetic nanoparticles (MNPs) are employed, particularly iron oxide nanoparticles with superparamagnetic nature, as probes within the MPI system. These MNPs enable the tracking and precise quantification of particle movement with minimal background noise. The 3D location and concentration of MNPs can provide better insights for multiple applications in vascular imaging, cell tracking, cancer cell imaging, inflammation, implant monitoring, and trauma imaging and can thus accelerate the diagnosis of disorders. The mononuclear phagocyte system provides a significant advantage, as they are involved in the spontaneous clearance of the tracers used in MPI, which readily minimise the toxic effects. Several studies have demonstrated that MPI-based functional neuroimaging is superior to other imaging modalities, providing adequate temporal resolution images with quick scan intervals. In MPI, nanoparticles are solely responsible for the source and visualisation, unlike magnetic resonance imaging (MRI), where nanoparticles were used only as supportive tracers. This review provides an overview of the principle, diagnostic, and therapeutic applications of MPI as well as the advantages and challenges MPI has over other diagnostic imaging methods in modern clinical setups.

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“…It is worth mentioning that several review articles have been published over the last three years, [45][46][47][48] most of which focused on a particular aspect of MPI, such as the instrumentation [49] or specific applications. [50][51][52][53][54][55] This article provides a comprehensive and up-to-date overview of MPI, including the most recent reports in tracer design and vascular abnormality imaging.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Xie,

Zhai,

Zhou

et al. 2023

Advanced Materials

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Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of a static magnetic gradient. In contrast with magnetic resonance imaging (MRI), which is driven by uniform magnetic fields and projects the anatomic information of the subjects, MPI directly tracks and quantifies MNPs in vivo without background signals. Moreover, it does not require radioactive tracers and has no limitations on imaging depth. This review first introduces the basic principles of MPI and important features of MNPs for advanced imaging sensitivity, spatial resolution, and targeted biodistribution. The latest research on optimized MPI tracers is reviewed based on their material composition, physical properties, and surface modifications. Since all the imaging benefits have led to a series of promising biomedical applications, we also discuss recent relational practices of MPI in vascular abnormalities, including cardiovascular and cerebrovascular systems, and cancers. Finally, some considerations of obstructions and recent progress closely related to the clinical translation of MPI are summarized to provide possible direction for future research and development.This article is protected by copyright. All rights reserved

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Magnetic Particle Imaging in Vascular Imaging, Immunotherapy, Cell Tracking, and Noninvasive Diagnosis

Cited by 6 publications

References 145 publications

Elucidating Iron Metabolism through Molecular Imaging

Elucidating Iron Metabolism through Molecular Imaging

Advancement of magnetic particle imaging in diagnosis and therapy

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

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