Magnetic Particle Imaging in Neurosurgery

Meola, Antonio; Rao, Jianghong; Chaudhary, Navjot; Song, Guosheng; Zheng, Xianchuang; Chang, Steven D.

doi:10.1016/j.wneu.2019.01.180

Cited by 32 publications

(26 citation statements)

References 62 publications

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“…Magnetic particle imaging has gained much attention in recent years due to its high signal to background noise ratio, zero background signal from tissues, [ 246 ] high temporal resolution (milli seconds), high spatial resolution (less than 1 millimeter) and high sensitivity (µg). [ 247 ] Magnetic particle imaging consists of two strong magnets placed at a distance where the orientation of strong magnetic dipole direct the magnetic force field in a specific way to create a field free point (FFP), where no magnetic force field is present. [ 248 ] The FFP point is not fixed and can be changed by varying relative position of the sample of interest to the position of applied magnetic field.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

“…SPIONs are excellent choices as tracer particles as they exhibits non linear magnetization and superparamagnetic properties. [ 247 ] The characterization of the SPIONs are done by Langevin magnetization, where magnetization (

M

) is represented as a function of magnetic field

H (t)

, and represented by the following Equations (5) and (6).

M (H (t)) = m_{s} [\coth (α H (t)) - (\frac{1}{α H ((), t)})]

α = \frac{μ_{0} m_{s}}{k_{normalB} T}

…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

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Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

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Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

M

) is represented as a function of magnetic field

H (t)

, and represented by the following Equations (5) and (6).

M (H (t)) = m_{s} [\coth (α H (t)) - (\frac{1}{α H ((), t)})]

α = \frac{μ_{0} m_{s}}{k_{normalB} T}

…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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“…Moreover, it presents excellent spatial resolution (<1 mm) without limits of penetration depth (for the utilization of magnetic fields) and it is background signal-free and has reasonably high sensitivity (200 nM Fe) and specificity. Moreover, it can be used in combination with other image techniques [ 18 , 113 , 116 , 117 , 118 ].…”

Section: Magnetic Nanoparticle-based Non-traditional Multimodal Imaging For Cancer Diagnosismentioning

confidence: 99%

“…The entire image is obtained with MPI is by scanning every point of the FFP or FFL in the concerned field of view [ 18 , 113 , 114 ] ( Figure 15 ). In this way the magnetic NPs can be traced, acquiring a temporal and spatial NP distribution directly proportional to the NP concentration [ 113 , 114 , 116 , 119 ].…”

Section: Magnetic Nanoparticle-based Non-traditional Multimodal Imaging For Cancer Diagnosismentioning

confidence: 99%

“…MPI can be utilized for imaging and monitoring diseases in several clinical applications, such as for cardiovascular diseases [ 113 , 136 ], cerebrovascular diseases [ 116 , 137 , 138 , 139 ], lung perfusion imaging [ 140 ], cancer diagnosis [ 118 ], and tracking of labeled stem cells [ 141 , 142 , 143 ]. Additionally, this imaging technology is also helpful in interventional applications [ 144 ] in which it can be used as catheter guidance [ 145 ].…”

Section: Magnetic Nanoparticle-based Non-traditional Multimodal Imaging For Cancer Diagnosismentioning

confidence: 99%

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Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles

et al. 2021

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Cancer is the second leading cause of death in the world, which is why it is so important to make an early and very precise diagnosis to obtain a good prognosis. Thanks to the combination of several imaging modalities in the form of the multimodal molecular imaging (MI) strategy, a great advance has been made in early diagnosis, in more targeted and personalized therapy, and in the prediction of the results that will be obtained once the anticancer treatment is applied. In this context, magnetic nanoparticles have been positioned as strong candidates for diagnostic agents as they provide very good imaging performance. Furthermore, thanks to their high versatility, when combined with other molecular agents (for example, fluorescent molecules or radioisotopes), they highlight the advantages of several imaging techniques at the same time. These hybrid nanosystems can be also used as multifunctional and/or theranostic systems as they can provide images of the tumor area while they administer drugs and act as therapeutic agents. Therefore, in this review, we selected and identified more than 160 recent articles and reviews and offer a broad overview of the most important concepts that support the synthesis and application of multifunctional magnetic nanoparticles as molecular agents in advanced cancer detection based on the multimodal molecular imaging approach.

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First magnetic particle imaging to assess pulmonary vascular leakage in vivo in the acutely injured and fibrotic lung

Feng,

Gao,

et al. 2023

Bioengineering & Transla Med

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Increased pulmonary vascular permeability is a characteristic feature of lung injury. However, there are no established methods that allow the three‐dimensional visualization and quantification of pulmonary vascular permeability in vivo. Evans blue extravasation test and total protein test of bronchoalveolar lavage fluid (BALF) are permeability assays commonly used in research settings. However, they lack the ability to identify the spatial and temporal heterogeneity of endothelial barrier disruption, which is typical in lung injuries. Magnetic resonance (MR) and near‐infrared (NIR) imaging have been proposed to image pulmonary permeability, but suffer from limited sensitivity and penetration depth, respectively. In this study, we report the first use of magnetic particle imaging (MPI) to assess pulmonary vascular leakage noninvasively in vivo in mice. A dextran‐coated superparamagnetic iron oxide (SPIO), synomag®, was employed as the imaging tracer, and pulmonary SPIO extravasation was imaged and quantified to evaluate the vascular leakage. Animal models of acute lung injury and pulmonary fibrosis (PF) were used to validate the proposed method. MPI sensitively detected the SPIO extravasation in both acutely injured and fibrotic lungs in vivo, which was confirmed by ex vivo imaging and Prussian blue staining. Moreover, 3D MPI illustrated the spatial heterogeneity of vascular leakage, which correlated well with CT findings. Based on the in vivo 3D MPI images, we defined the SPIO extravasation index (SEI) to quantify the vascular leakage. A significant increase in SEI was observed in the injured lungs, in consistent with the results obtained via ex vivo permeability assays. Overall, our results demonstrate that 3D quantitative MPI serves as a useful tool to examine pulmonary vascular integrity in vivo, which shows promise for future clinical translation.

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Magnetic Particle Imaging in Neurosurgery

Cited by 32 publications

References 62 publications

Recent progress of magnetic nanoparticles in biomedical applications: A review

Recent progress of magnetic nanoparticles in biomedical applications: A review

Recent Advances in Multimodal Molecular Imaging of Cancer Mediated by Hybrid Magnetic Nanoparticles

First magnetic particle imaging to assess pulmonary vascular leakage in vivo in the acutely injured and fibrotic lung

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