Magnetic Particle Imaging: Current and Future Applications, Magnetic Nanoparticle Synthesis Methods and Safety Measures

Billings, Caroline; Langley, Mitchell; Warrington, Gavin; Mashali, Farzin; Johnson, Jacqueline A.

doi:10.3390/ijms22147651

Cited by 70 publications

(62 citation statements)

References 113 publications

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“…The functionalization of NPs enables their utilization in a variety of biotechnological and biomedical applications. They are used as biosensors, in diagnostics as contrast agent for magnetic resonance imaging (MRI), magnetic particle imaging (MPI), ultra sound (US), positron emission tomography (PET), photo acoustic tomography (PAT) and computed tomography (CT), and in the treatment of diseases, through targeted or stimuli-responsive drug delivery of bioactive agents, in tissue engineering and regeneration [ 28 , 30 , 31 , 32 , 33 , 34 , 35 ]. Due to their magnetic properties, applications such as hyperthermia or magnetically guided drug delivery are possible [ 26 , 34 , 36 , 37 ].…”

Section: Ionp Synthesis Functionalization and Targetingmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Section: Ionp Synthesis Functionalization and Targetingmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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“…They have also demonstrated the feasibility of the imaging method through the achievement of the image with resolution below 1 mm [265]. MPI, as a tracer-based tomographic imaging modality, can determine the spatial distribution of magnetic nanoparticles (MNPs) and has applications in vast biomedical arenas, such as cell targeting, drug delivery, and diagnostic imaging, as well as in magnetic hyperthermia [266]. Nowadays, magnetic particle spectroscopy (MPS) or magnetisation response spectroscopy (MRS) is evolving as a versatile measurement tool derived from MPI.…”

Section: Application Of Aunps In Magnetic Particle Imaging (Mpi)mentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Bharadwaj

Rabha

Pati³

et al. 2021

Molecules

115

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Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists’ attention to exploring the green synthesis of AuNPs by exploiting plants’ secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy.

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“…Since nanotechnological research turned its attention to the biomedical field and nanomedicine was born [ 1 ], the development of new nanoproducts has necessarily involved the study of their interactions with the biological environment. Whatever the nanoconstructs are intended for, e.g., as drug delivery systems, contrast agents, biosensors, sorting systems or scaffold components [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ], the knowledge of their structural and functional interactions with cells, tissues and organs is essential to ensure both safety and efficacy. Imaging techniques have played a primary role in meeting this need.…”

Section: Introductionmentioning

confidence: 99%

Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures

Malatesta

2021

IJMS

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Nanomedical research necessarily involves the study of the interactions between nanoparticulates and the biological environment. Transmission electron microscopy has proven to be a powerful tool in providing information about nanoparticle uptake, biodistribution and relationships with cell and tissue components, thanks to its high resolution. This article aims to overview the transmission electron microscopy techniques used to explore the impact of nanoconstructs on biological systems, highlighting the functional value of ultrastructural morphology, histochemistry and microanalysis as well as their fundamental contribution to the advancement of nanomedicine.

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Magnetic Particle Imaging: Current and Future Applications, Magnetic Nanoparticle Synthesis Methods and Safety Measures

Cited by 70 publications

References 113 publications

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Transmission Electron Microscopy as a Powerful Tool to Investigate the Interaction of Nanoparticles with Subcellular Structures

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