Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field

Le-Deygen, Irina M.; Vlasova, Kseniya Yu.; Kutsenok, E.O.; Usvaliev, Azizbek D.; Efremova, M. V.; Zhigachev, Andrey O.; Rudakovskaya, Polina G.; Golovin, D. Yu.; Gribanovsky, Sergey L.; Kudryashova, Еlena V.; Majouga, Alexander G.; Golovin, Yuri I.; Kabanov, Alexander V.; Klyachko, Natalia L.

doi:10.1016/j.nano.2019.102065

Cited by 16 publications

(20 citation statements)

References 46 publications

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“…Liposome-MNP complexes were formed due to the electrostatic interaction between dopamine bound to MNPs and lipid anionic units (mostly phosphates). A 5 min exposure to AMF at a frequency of 50–150 Hz resulted in the release of the cargo of low molecular weight compounds, as reported in [ 117 ], for sodium chloride. The effects depended upon the frequency and intensity of AMF (see Table 2 ).…”

Section: Some Experimental Resultsmentioning

confidence: 74%

“…The effects depended upon the frequency and intensity of AMF (see Table 2). As shown by infrared (IR) spectroscopy, the oscillation of MNP in AMF results in the loosening of the liposome membrane, which resembles phase transition [117]. NMMA has the potential to modulate the functioning of nerve tissues [73].…”

Section: Some Experimental Resultsmentioning

confidence: 99%

“…It should be noted that this is principally impossible for MHT. Taking the above into account, and employing the described models, more physically substantiated experiments were carried out [ 53 , 55 , 56 , 117 , 128 ]. The conditions for the most effective NMMA application found in these papers were generally in agreement with our theoretical considerations, which were presented in [ 46 , 47 , 48 , 115 , 129 , 130 , 131 ].…”

Section: Some Experimental Resultsmentioning

confidence: 99%

“…The behavior of rod-shaped MNPs in AMF is even more complicated, which opens additional possibilities for controlling the effect of AMF. There is some evidence that such MNPs may be more effective than spheroidal ones [ 115 , 116 , 117 , 118 ], whereas rod-like MNPs do not require strong bonds to MM or other particles to induce significant deformation. Thus, the MNP and AMF parameter requirements for MHT and HMMA applications are exactly the opposite ( Figure 3 ).…”

Section: Theoretical Considerationsmentioning

confidence: 99%

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Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Golovin

Vlasova

et al. 2021

Nanomaterials

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The review discusses the theoretical, experimental and toxicological aspects of the prospective biomedical application of functionalized magnetic nanoparticles (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are used as mediators that localize and apply force to such target biomolecular structures as enzyme molecules, transport vesicles, cell organelles, etc., without significant heating. It is shown that NMMA can become a biophysical platform for a family of therapy methods including the addressed delivery and controlled release of therapeutic agents from transport nanomodules, as well as selective molecular nanoscale localized drugless nanomechanical impacts. It is characterized by low system biochemical and electromagnetic toxicity. A technique of 3D scanning of the NMMA region with the size of several mm to several cm over object internals has been described.

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Section: Some Experimental Resultsmentioning

confidence: 74%

Section: Some Experimental Resultsmentioning

confidence: 99%

Section: Some Experimental Resultsmentioning

confidence: 99%

Section: Theoretical Considerationsmentioning

confidence: 99%

See 2 more Smart Citations

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Golovin

Vlasova

et al. 2021

Nanomaterials

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“…Г.Р. Державина и Университета Северной Каролины (США) запатентован и развит биомеханический подход к неинвазивной терапии нового поколения, заключающийся в селективной наномагнито-механическиой активации (NMMA) целевых биомолекулярных структур [256,257,[266][267][268][269][270]. Приложение принципов стрейнтроники -управления характеристиками материалов и нанообъектов посредством их контролируемой деформации -позволяет Force , N P 10 -13 10 -12 10 -11 10 -10 10 -9 10 -8 10…”

Section: разрушение в микро- субмикрои наношкалеunclassified

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Головин¹

2021

Физика Твердого Тела

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The review discusses the details of various materials mechanical behavior in submicro- and nanoscale. Significant advances in this scope result from the development of wide family of load based precise nanotesting techniques called nanoindentation. But nowadays, nanomechanical properties are studied not only by nanoindentation techniques in narrow sense, i.e. local loading of macro, micro and nanoscale objects. Nanomechanical load testing is discussed here within a wider scope employing precise deformation measurement with nanometer scale resolution caused by various types of low load application to the object under study including uniaxial compression or extension, shearing, bending or twisting, optionally accompanied by in situ monitoring sample microstructure using scanning and transmission electron microscopy and Laue microdiffraction technique. The main courses of experimental techniques development in recent ten years along with the results obtained using them in single, poly and nano crystalline materials, composites, films and coatings, amorphous solids and such biomaterials as tissues, living cells and macromolecules are described. Special attention is paid to deformation size effects and atomic mechanisms in nanoscale. This review is a natural continuation and development of the review published at Fiz.Tverd.Tela vol.50, issue 12, 2008 of the same author that discusses details of nanomechanical properties of solids. Current review includes wider range of nanomechanical testing concepts and recent achievements in the scope. The work was supported by RFBR grant for project #19-12-50235.

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Mechanisms and conditions for mechanical activation of magnetic nanoparticles by external magnetic field for biomedical applications

Gribanovsky

Zhigachev

Golovin

et al. 2022

Journal of Magnetism and Magnetic Materials

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Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field

Cited by 16 publications

References 46 publications

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic Biomedical Applications

Наноиндентирование И Механические Свойства Материалов В Субмикро- И Наношкале. Недавние Результаты И Достижения (О Б З О Р)

Mechanisms and conditions for mechanical activation of magnetic nanoparticles by external magnetic field for biomedical applications

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