Magnetic nanoprobe-enabled lateral flow assays: recent advances

Abstract

In recent years, magnetic nanoparticle sensor technologies have attracted considerable interest in the point-of-care-testing (POCT) field, especially in Lateral Flow Immunoassays (LFIA). Although the visual signal of magnetic nanoparticles is...

Advancements in magnetic nanoparticle-based biosensors for point-of-care testing

“…For instance, Li J. et al (2017) developed a magnetic nano-biosensor utilizing MNPs, fluorescence-activated cell sorting (FACS), and magnetic separation for the rapid clinical diagnosis of cancer patients, particularly in detecting circulating tumor cells (CTCs). MNPs also find applications in diverse biomedical fields, including targeted drug delivery ( Guo et al, 2022 ), bioimaging ( Zong et al, 2021 ), targeted hyperthermia for cancer treatment ( Zhao et al, 2019 ; Dash et al, 2022 ), as well as the capture, isolation, concentration, and detection of nucleic acids ( Zhao et al, 2023 ), bacteria ( Behzad et al, 2022 ), and viruses ( Labib et al, 2021 ; Xing et al, 2022 ), They have proven effective in immunoassays and immune sensors ( Ha and Kim, 2022 ; Li et al, 2023 ).…”

Disposable capillary-fill device for the determination of proteases incorporating elimination of light-shielding from the magnetic beads with cleavage of the electrogenerated chemiluminescence label-tagged peptide probe

“…has advantages in the preconcentration and separation of target analytes, which is beneficial for developing automated assay and POCT platforms. 25,26 In recent years, a series of micro- or nano-MB-based ECL biosensing methods for the determination of proteases have been developed. In 2018, Zhou's group reported an ECL biosensing method for the detection of tryptase and caspase-3 using peptide-modified MBs.…”