Magnetic Nanoparticles Molecularly Imprinted Polymers: A Review

Abstract

The molecularly imprinted polymers (MIPs) technology, which has been around since the 1970s, has grown in popularity in recent decades. MIPs have shown to be a useful approach for determining target molecules in complicated matrices containing other structurally similar and related chemicals. Despite MIPs have intrinsic polymer features such as stability, robustness, and low-cost production, traditional MIPs have a number of drawbacks. Surface molecular imprinting appears to be an alternative approach that can address some of the drawbacks of traditional MIP by anchoring shells to the surface of matrix carriers such as nanoparticles. The incorporation of nanoparticles into the polymeric structure of MIPs can improve their properties or provide novel capabilities. Magnetic nanoparticles have been widely explored for their separation and extraction capability. Magnetic components in MIP can help develop a regulated rebinding process, allowing magnetic separation to substitute centrifugation and filtration stages in a simple and cost-effective strategy. Polymers are created directly on the surface of a magnetic substrate to create a unique material termed magnetic molecularly imprinted polymer (MMIP). These materials have been widely used to extract molecules from complex matrices in a variety of applications, especially in environmental, food, and biological studies. This paper seeks to summarize and discuss the nanoparticle synthesis and magnetic nanoparticle combination in the MIP preparation. The novel applications of MMIP in environmental, food, and biological analysis are also discussed in this paper.

Fabrication and characterization of a novel magnetic nanostructure based on pectin–cellulose hydrogel for in vitro hyperthermia during cancer therapy

“…29,30 In this context, Fe 3 O 4 MNPs have been highlighted due to their superparamagnetic behavior, large surface area, ease of surface functionalization, formation of a stable suspension, and substantial physiochemical properties. 31,32 As documented recently by Mandal et al, the Fe 3 O 4…”

“…29,30 In this context, Fe 3 O 4 MNPs have been highlighted due to their superparamagnetic behavior, large surface area, ease of surface functionalization, formation of a stable suspension, and substantial physiochemical properties. 31,32 As documented recently by Mandal et al , the Fe 3 O 4 MNPs interact effectively with polymeric substrates via their functional groups. However, the surface coating of the Fe 3 O 4 MNPs is a desirable choice to hinder their aggregation through interparticular dipole–dipole attractions.…”

Molecularly Imprinted Polymer-Based Adsorbents for the Selective Removal of Pharmaceuticals from Wastewater: Adsorption Kinetics, Isotherms, and Thermodynamics Studies

“…With the use of magnetic components in MIP, a controlled rebinding process may be developed, enabling magnetic separation to replace the centrifugation and filtration phases in a straightforward, economical method . Magnetic molecularly imprinted polymers are developed by directly forming polymers on the surface of a magnetic substrate (MMIP) . The selection of the magnetic adsorbent for MSPE is crucial for attaining good extraction performance since it has a significant impact on the extraction efficiency, enrichment factor, selectivity, and anti-interference ability .…”

“…Accordingly, MIPs exhibit the intrinsic qualities of polymers, such as stability, resilience, ease, and low-cost production. Moreover, some of these qualities can be improved and additional functionalities can be achieved when nanoparticles are introduced into their polymeric structure. , Notably, MIP nanoparticles (nanoMIPs) have attracted the most attention from researchers among all nanomaterial sorbents due to their potential for use in significant extraction procedures. Furthermore, nanoMIPs are a significant advancement in imprinting technology since they address several issues with bulk polymerized MIP, including uneven recognition site distribution, irregular shape, partial template removal, and delayed mass transfers . The summary of nanoparticle application on the removal of pharmaceuticals in water and wastewater is shown in Table S9.…”

Boronate affinity-based clindamycin-imprinted magnetic nanomaterials for rapid, efficient and selective extraction and determination of clindamycin in animal-derived food

“…Molecularly imprinted polymers (MIPs) have been used as efficient solid phase extraction (SPE) adsorbents due to their high specificity, easy preparation, low cost and physical and chemical stability. [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] Thus, the molecularly imprinted materials can be well applied for separation and enrichment of CLN in food samples. To the best of our knowledge, there has been no report on molecularly imprinted materials for separation and enrichment of CLN to date.…”