Magnetic nanoparticles mediated cancer hyperthermia

Effects of an Alternating Magnetic Field towards Dispersion of α-Fe2O3/TiO2 Magnetic Filler in PPOdm Polymer for CO2/CH4 Gas Separation

“…Due to the relatively large size of the particles synthesized in our study, Neel’s relaxation time was ruled out as it only occurs with nanoscale particles, which are superparamagnetic. As for hysteresis loss, it was ruled out because it generally requires a magnetic field amplitude of at least two times the coercivity of the particle [ 25 ]. The amplitude of the AMF in our study was 10 G, whereas the coercivity of the particle was measured to be 34.64 G. Since the heat dissipation was mainly generated by the Brownian relaxation phenomenon in our case, it is of interest to maximize the amount of heat dissipation to increase the rate of rotational movement by Brownian relaxation from the MSP fillers.…”

Development of pH-Sensitive Magnetoliposomes Containing Shape Anisotropic Nanoparticles for Potential Application in Combined Cancer Therapy

“…The rapid and uncontrolled proliferation of tumor cells to adjacent tissues and organs, as well as the lack of targeted therapies with reduced systemic toxicity, make cancer one of the diseases with the highest mortality rate [ 1 ]. Several limitations associated with conventional treatments, specifically in the pharmacokinetic profile of the drug (e.g., reduced specificity, systemic toxicity and early metabolization and elimination) [ 2 ], point to an urgent need to develop new therapeutic approaches that allow the safe use of anticancer drugs.…”

Dipolar interactions among magnetite nanoparticles for magnetic hyperthermia: a rate-equation approach

“…The research activity is developing along two main lines; the first one involves the progress in materials science and chemistry with the aim to produce nanomaterials and/or nanostructures characterized by a combination of exciting properties of potential interest in biomedicine, renewable energy technology, electronics and often characterized by a high degree of engineering at the nanoscale [2,3,4,5]; a second line involves the optimization of the performance of known nanomaterials such as iron-oxide based NPs, where a large margin of improvement is still possible [4,5]. This line of development is actively followed when magnetic NPs are considered for use in biosensing and medicine, where they provide innovative solutions for the clinical treatment of a variety of diseases [1,6], including early diagnosis [7], accurate bioimaging [8,9] and above all significant advances in therapeutic efficacy [9,10,11,12]. Anti-tumor therapies based on, or assisted by magnetic nanoparticles are effective in overcoming the resistance of some types of malignant cells to standard treatments [13,14].…”

“…Nanoparticles made of magnetic Fe oxides such as magnetite, maghemite or a combination of both have been long since recognized as the most promising nanomaterials for in-vivo applications [15,16], owing to the ease of preparation [17] and low toxicity [18]. Fe-oxide nanoparticles in the range 10-20 nm can be used either as magnetically driven nanocarriers in standard or heat-assisted drug delivery [19,20] or as magnetically activated, pointlike heat sources in magnetic hyperthermia [10]. The latter practice has come to play a central role in precision nanomedicine, an innovative branch of medicine where nanotechnology helps overcoming treatment resistance of cancer cells by exploiting the physical properties of nanomaterials [21,22,23].…”