Magnetic nanoparticles: mechanistic studies on the cancer cell interaction

Jacob, Joe Antony; Salmani, Jumah Masoud Mohammad; Chen, Baoan

doi:10.1515/ntrev-2016-0022

Cited by 18 publications

(8 citation statements)

References 65 publications

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“…SPIONs exert their cytotoxic effects through multiple molecular mechanisms. 38 These include the induction of apoptosis, ROS generation, cell cycle arrest, and the disruption of cell membrane integrity.…”

Section: Synthesis Of Capped Organophilic Spions (O-spions) and Highl...mentioning

confidence: 99%

Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Karouta

Simos

Basina

et al. 2023

ACS Appl. Nano Mater.

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Superparamagnetic iron oxide nanoparticles (SPIONs) are becoming important vehicles for biomedical applications. This study demonstrates a new strategy based on a "haircut" reaction, aiming at the design of highly hydrophilic and functional nanoparticles. The as-synthesized SPIONs have a diameter of ∼4 nm and reveal super-organophilic behavior due to their surface modification by oleylamine molecules present on their surface (o-SPIONs). The "trimming", which is applied on the oleylamine molecule double bond, produces shorter chains terminated by carboxyl groups, with the resulting nanoparticles exhibiting high hydrophilicity, dispersibility in water, and functionality (h-SPIONs). The biological behavior of h-SPIONs is studied against three different cell lines and reveals a selective cytotoxic effect against cancer cells. This novel method of engineering the surface properties of nanoparticles can lead to the development of a new generation of functional nanomaterials. In addition, h-SPIONs can evolve into a new and expanding family of magnetic nanomaterials in future biomedical systems.

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Section: Synthesis Of Capped Organophilic Spions (O-spions) and Highl...mentioning

confidence: 99%

Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Karouta

Simos

Basina

et al. 2023

ACS Appl. Nano Mater.

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“…Diverse studies have been proposing some mechanisms of cytotoxicity of the eugenol in tumor cells, for instance, Jaganthan et al [30] and Ghost et al [31] report that effect against colon cancer and melanoma occurs by antiproliferative effect and induction of apoptosis. Regarding iron oxide nanoparticles, the mechanisms described are the generation of reactive oxygen species, inhibition of chemoresistant proteins, impairment of mitochondrial function, damage of DNA, and increase of apoptotic signals [32,33].…”

Section: Ic 50 Values Of Hacat and A375 Cell Linesmentioning

confidence: 99%

Synthesis, Characterization, and Biological Activity Evaluation of Magnetite-Functionalized Eugenol

Bruckmann

Viana

Lopes

et al. 2022

J Inorg Organomet Polym

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In this work, we report, for the rst time, the magnetite-functionalization and biological evaluation of eugenol by the co-precipitation method employed only Fe 2+ under mild conditions and control from the amount of the incorporated magnetite. Magnetic nanoparticles were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), and hydrodynamic size distribution (Zetasizer). SEM images showed that EUG•Fe 3 O 4 is 200 nm in size and similar in shape to a nano ower. The FTIR spectrum con rmed the presence of characteristic EUG and Fe 3 O 4 bands in the EUG•Fe 3 O 4 sample, while the XRD analysis showed that the magnetite functionalization with eugenol slightly affected the Fe 3 O 4 crystal structure. The in vitro safety pro le and cytotoxicity of free eugenol, magnetite pristine, EUG•Fe 3 O 4 1:1, EUG•Fe 3 O 4 1:5, and EUG•Fe 3 O 4 1:10 was investigated using human cell lines (keratinocytes and melanoma). The results demonstrate the high biocompatibility of EUG•Fe 3 O 4 in HaCat cells and the greater speci city for the A375 cell line. Furthermore, the magnetite-functionalized with eugenol decreased the toxic effects of free eugenol on healthy cells. Antibacterial tests were performed in different bacterial strains. The experimental data showed that among the magnetic compounds, the microorganisms were only sensitive to treatment with EUG•Fe 3 O 4 1:1. Regarding the antibio lm activity assay, it can be observed that only the EUG•Fe 3 O 4 caused a signi cant decrease in biomass when compared to the positive control. Finally, it can be concluded that EUG•Fe 3 O 4 proves to be a potential candidate for future studies for drug delivery of cancer and bacterial infections treatments. IntroductionRecently, the development of drug delivery systems has been widely investigated due to the limitations of conventional treatments, such as insolubility, low stability, toxicity, and serious adverse effects [1, 2]. In addition, some drugs have di culty in reaching distant organs. Thus, nanotechnology through atomic and molecular manipulation of materials enables the synthesis of nanoparticles with new properties and applications, allowing its application in diverse areas [3, 4,5]. A variety of nanoparticles have been developed as a vehicle for drug targeting that can show different sizes, shapes, and chemical compositions [6]. Among nanoparticulated systems, magnetic nanoparticles (MNPs) have been demonstrated excellent nanoplatforms for drug delivery due to unique properties such as biocompatibility, easy preparation, and functionalization [7, 8].Particularly, superparamagnetic iron oxide nanoparticles (SPIONs) (Fe 3 O 4 and γ-Fe 2 O 3 ) have been promising in biological activity studies due to their easy metabolism, biodegradability, and biocompatibility. Superparamagnetic nanoparticles have advantages over other metallic nanoparticles.The fact that SPIONs exhibit magnetic behavior only approaching a magnet decrease clot formation and biological agglomeration [9,10].Likewise,...

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“…Dessa forma, as forças de atração entre os grupos amino protonados da quitosana são favorecidas, podendo resultar na ruptura da membrana celular e na liberação de citocinas inflamatórias (Zhang et al, 2010). Em relação às nanopartículas magnéticas, diversos mecanismos são descritos, como geração de espécies reativas, danos ao material genético e ferroptose (JACOB et al, 2016;REVIA e ZHANG, 2016).…”

Section: Ensaio Ldhunclassified

Avaliação Da Atividade in Vitro De Um Complexo Biopolimero- Magnético-Quimioterápico Pós Adsorção

NUNES¹,

BRUCKMANN²,

SILVA³

et al. 2022

Anais Do Simpósio De Ensino, Pesquisa E Extensão (SEPE 2022)

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O metotrexato é amplamente empregado como agente quimioterapico no tratamento do câncer. Todavia sua elevada excreção na forma inalterada colabora para a sua liberação exacerbada no meio ambiente, promovendo em última análise a contaminação aquática. A adsorção de contaminantes por meio do uso de quitosana magnética (CS•Fe3O4) é uma alternativa que atende as demandas à remoção de poluentes de recursos hídricos. Em razão dos excelentes resultados obtidos para adsorção de MTX em CS•Fe3O4 este trabalho teve como objetivo avaliar a atividade biológica in vitro do complexo MTX/CS•Fe3O4 por meio dos ensaios do MTT, e LDH em células tumorais de melanoma humano e células de fibroblastos de camundongos. De acordo com os resultados obtidos o complexo apresenta maior biocompatibilidade que o MTX livre. Em relação a atividade antitumoral, evidenciouse que o complexo é mais citotoxico que o MTX livre, possibilitando que estudos futuros explorem essa atividade frente outras linhagens.

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Magnetic nanoparticles: mechanistic studies on the cancer cell interaction

Cited by 18 publications

References 65 publications

Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Synthesis, Characterization, and Biological Activity Evaluation of Magnetite-Functionalized Eugenol

Avaliação Da Atividade in Vitro De Um Complexo Biopolimero- Magnético-Quimioterápico Pós Adsorção

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