Magnetic nanoparticles in cancer diagnosis and treatment: a review

Karkan, Sonia Fathi; Mohammadhosseini, Majid; Panahi, Yunes; Milani, Morteza; Zarghami, Nosratollah; Akbarzadeh, Abolfazl; Abasi, Elham; Hosseini, Arastoo; Davaran, Soodabeh

doi:10.3109/21691401.2016.1153483

Cited by 75 publications

(21 citation statements)

References 55 publications

(69 reference statements)

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“…These data indicate cancer to be one of the diseases with the highest rate of morbidity and mortality nowadays. Finding effective methodologies for early detection, diagnosis and treatment has become a fundamental objective when developing NPs as DDSs [ 67 , 68 , 69 ]. Ordinary imaging and diagnosis techniques can only detect tumor mass when it is at least one-centimeter in size, being notably difficult to detect cancer at early stages [ 70 ].…”

Section: Polymeric Nanoparticles In Cancer Diagnosis and Imagingmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

et al. 2020

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The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.

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Section: Polymeric Nanoparticles In Cancer Diagnosis and Imagingmentioning

confidence: 99%

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

et al. 2020

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“…Thereupon, with the application of external magnetic fields (highgradient), the particular drug delivery system (DDS) is targeted specifically at cancerous cells via changes in physiological conditions (osmolality, enzymatic activity and temperature). Indeed, by applying this strategy the associated side-effects along with the amount of the drug delivered are reduced, ultimately leading to reduced systemic toxicity (122,123). Seo et al (124).…”

Section: Biocompatible Nanomaterials For Cancer Diagnosismentioning

confidence: 99%

Anti-cancer green bionanomaterials: present status and future prospects

Barabadi

Ovais

Shinwari

et al. 2017

Green Chemistry Letters and Reviews

169

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Cancer is one of the most common health problems responsible for outnumbered deaths worldwide. Nanomedicine plays an important role in developing alternative and more effective treatment strategies for cancer theranostics. However, the toxicity, high cost and nanoparticles (NPs) production complexity are some of the major issues that obstruct the use of existing nanomedicine. Recently, the green synthesis of biogenic NPs from plants and microbial sources has become an emerging field due to their safer, eco-friendly, simple, fast, energy efficient, lowcost and less toxic nature. Interestingly, NPs play a key role in diagnosis of tumor at the initial stage by allowing cellular visualization. Furthermore, prospective applications of green NPs include magnetically responsive drug delivery, anti-cancer activity, photo-thermal therapy and bio-imaging. The present review provides perspective on the use of anti-cancer green bionanomaterials with a focus on their present status and future prospects in the theranostics of cancer.

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“…The multiple pathways involved in cancer therapy has further complicated the design of effective therapeutic system. Hence, a paradigm shift is underway as researchers are working to analyze individual tumors in order to design therapies for specific cancer phenotypes [7,8].…”

Section: Challenges In Drug Delivery To Tumor Microenvironmentmentioning

confidence: 99%

Epidermal growth factor receptor based active targeting: a paradigm shift towards advance tumor therapy

Akhter

Madhav

Ahmad

2018

Artificial Cells, Nanomedicine, and Biotechnology

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The epidermal growth factor receptor (EGFR) is a cell surface receptor belonging to erythroblastic leukemia viral oncogene homologue (ErbB) family of tyrosine kinase. It plays critical role in the regulation of cell proliferation, survival and differentiation. The EGFR receptor is crucial in a variety of tumor development due to unlikely triggered by receptor overexpression, chromosomal mutation and or ligand-dependent receptor dimerization. The EGFR inhibition established a major therapeutic target in cancer therapy. The signal transduction pathway of EGFR is directly involved in tumor pathogenesis and progression. The combinatorial approach with EGFR inhibitors bring novel therapeutic regime with proved clinical efficacy. This critique briefly addressed EGFR receptor characteristics, worldwide report on various cancers and EGFR based potential targeting modalities in skin, breast, ovary, brain, lungs, pancreas, gastric and colorectal tumors and molecular pathways involved in EGFR targeting.

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Magnetic nanoparticles in cancer diagnosis and treatment: a review

Cited by 75 publications

References 55 publications

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

Anti-cancer green bionanomaterials: present status and future prospects

Epidermal growth factor receptor based active targeting: a paradigm shift towards advance tumor therapy

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