Magnetic Nanoparticles Enhance Adenovirus Transduction In Vitro and In Vivo

Sapet, Cédric; Pellegrino, Christophe; Laurent, Nicolas; Sicard, Flavie; Zelphati, Olivier

doi:10.1007/s11095-011-0629-9

Cited by 38 publications

(28 citation statements)

References 70 publications

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“…These attributes of magnetic nanoparticles make them promising candidates to actively monitor the pharmacokinetics of therapeutics and can enhance delivery of therapeutics to target tissue. Recently, Sapet et al developed a magnetic nanoparticle-complexed Ad vector and showed accelerated vector accumulation at target sites under external MFG [114]. The Ad-magnetic hybrid system (Ad-MnMEIO) has been developed for gene delivery and concurrent MR imaging [115].…”

Section: Magnetic Field-mediated Local Delivery Of Viral Vectorsmentioning

confidence: 99%

Evolving Lessons on Nanomaterial-Coated Viral Vectors for Local and Systemic Gene Therapy

Kasala

Yoon

Hong

et al. 2016

Nanomedicine (Lond.)

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Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid dissemination to nontarget tissues and to the immunogenicity of viral vectors, resulting in poor retention at the disease locus and induction of adverse inflammatory responses in patients. Further, the limited tropism of viral vectors prevents efficient gene delivery to target tissues. In this regard, modification of the viral surface with nanomaterials is a promising strategy to augment vector accumulation at the target tissue, circumvent the host immune response, and avoid nonspecific interactions with the reticuloendothelial system or serum complement. In the present review, we discuss various chemical modification strategies to enhance the therapeutic efficacy of viral vectors delivered either locally or systemically. We conclude by highlighting the salient features of various nanomaterial-coated viral vectors and their prospects and directions for future research.

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Section: Magnetic Field-mediated Local Delivery Of Viral Vectorsmentioning

confidence: 99%

Evolving Lessons on Nanomaterial-Coated Viral Vectors for Local and Systemic Gene Therapy

Kasala

Yoon

Hong

et al. 2016

Nanomedicine (Lond.)

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“…To enhance transduction efficiency, viral surfaces are modified with cationic polymers and lipids via ionic interactions because the net charge of a viral particle surface is negative, approximately −20 mV [100-102], which is not preferable for facile interaction with anionic cellular surface. Adenoviruses have been complexed with commercial magnetic nanoparticles AdenoMag (OZ Biosciences) via electrostatic and hydrophobic interactions for magnetically-driven delivery, which showed significantly increased transduction for cells poorly expressing Coxsackie-adenovirus receptor (CAR) on cellular surface like NIH-3T3 cells (mouse fibroblast cells) [103]. Approximately 3.5-fold higher gene transfections were observed via magnetofection for NIH-3T3 cells compared with transfection without cationic polymer coated virus (polybrene-virus mixture).…”

Section: Applications Of Spion-based Delivery Systems For Biotheramentioning

confidence: 99%

“…The polymag™ particles (100–200 nm, OZ Biosciences, France) showed plasmid DNA delivery to NCI-H292 human lung epithelial cells 4-fold greater than the commercial lipid-based carrier, lipofectamine [32]. In addition, lipomag™ particles and Adenomag have been developed for gene delivery and virus delivery, respectively [89, 103]. The diverse fluidMAG particles (Chemicell) are magnetic nanoparticles coated with various polymers including chitosan, starch, and PVA, and lipids [84, 105].…”

Section: Commercialized Magnetic Nanoparticles For the Delivery Ofmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics

Mok

Zhang

2012

Expert Opinion on Drug Delivery

120

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Introduction Superparamagnetic iron oxide nanoparticle (SPION)-based carrier systems have many advantages over other nanoparticle-based systems. They are biocompatible, biodegradable, facilely tunable, and superparamagnetic and thus controllable by an external magnetic field. These attributes enable their broad biomedical applications. In particular, magnetically-driven carriers are drawing considerable interest as an emerging therapeutic delivery system because of their superior delivery efficiency. Area covered This article reviews the recent advances in use of SPION-based carrier systems to improve the delivery efficiency and target specificity of biotherapeutics. We examine various formulations of SPION-based delivery systems, including SPION micelles, clusters, hydrogels, liposomes, and micro/nanospheres, as well as their specific applications in delivery of biotherapeutics. Expert opinion Recently, biotherapeutics including therapeutic cells, proteins and genes have been studied as alternative treatments to various diseases. Despite the advantages of high target specificity and low adverse effects, clinical translation of biotherapeutics has been hindered by the poor stability and low delivery efficiency compared to chemical drugs. Accordingly, biotherapeutic delivery systems that can overcome these limitations are actively pursued. SPION-based materials can be ideal candidates for developing such delivery systems because of their excellent biocompatibility and superparamagnetism that enables long-term accumulation/retention at target sites by utilization of a suitable magnet. In addition, synthesis technologies for production of finely-tuned, homogeneous SPIONs have been well developed, which may promise their rapid clinical translation.

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“…The thermo-sensitive polymer will serve as a scaffold for MSCs, and spatiotemporal control of growth factor release will be achieved with genes triggered by exo genous signals (temperature, doxycycline) to direct cartilage and subchondral bone regeneration (49,50) . Alternatively, MSC can be transduced ex vivo by magnetofection (51,52) and then injected within the thermo-sensitive polymer into the damaged cartilage and activated as above.…”

Section: The Gene Vectorsmentioning

confidence: 99%

“…Alternatively an approach using magnetically enhanced adenoviral gene transfer to human MSC in monolayer culture has been successfully established using AdenoMag and the Viro-MICST infection method on a magnetic cell separation column (51,52) .…”

Section: Induction By Infl Ammationmentioning

confidence: 99%

Gene activated matrices for bone and cartilage regeneration in arthritis

Plank

Eglin

Fahy

et al. 2012

European Journal of Nanomedicine

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The GAMBA Consortium is developing a novel gene-activated matrix platform for bone and cartilage repair with a focus on osteoarthritis-related tissue damage. The scientifi c and technological objectives of this project are complemented with an innovative program of public outreach, actively linking patients and society to the evolvement of this project. The GAMBA platform will implement a concept of spatiotemporal control of regenerative bioactivity on command and demand.

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Magnetic Nanoparticles Enhance Adenovirus Transduction In Vitro and In Vivo

Cited by 38 publications

References 70 publications

Evolving Lessons on Nanomaterial-Coated Viral Vectors for Local and Systemic Gene Therapy

Evolving Lessons on Nanomaterial-Coated Viral Vectors for Local and Systemic Gene Therapy

Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics

Gene activated matrices for bone and cartilage regeneration in arthritis

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