Magnetic Nanoparticles Encapsulated Zeolitic Imidazolate Frameworks: A New Delivery System for Crocin

Abstract

The synthesis of magnetic nanoparticles enclosed in zeolitic imidazolate frameworks (MNPs@ZIF-8) was successful carried out at ambient temperature and atmospheric pressure. The synthesis procedure was selected because it is uncomplicated and does not call for the use of any sophisticated pieces of apparatus throughout its execution. The Fourier transform infrared (FT-IR), X-ray diffraction (XRD), and transmission electron microscopy (TEM) images were investigated to characterize the materials. The analysis of the data allowed MNPs@ZIF-8 to evolve into a highly crystalline phase with particles ranging in size from 50 to 100 nanometers. This was made feasible by the fact that the phase could be created. It was explored whether or not MNPs@ZIF-8 was effective as a nanocarrier for the delivery of natural medicines like crocin. It was demonstrated to be very biocompatible and had an IC50 value of > 1000 μg/mL, which is the concentration at which half of the maximum inhibitory effect is produced. The IC50 value for crocin-loaded MNPs-ZIF-8 was 419 ± 0 μg/mL, which was roughly half of the IC50 value for pure crocin, which was 716 ± 160 μg/mL.

Cerium‐based metal–organic frameworks (MOFs) as a sustainable approach to mitigating environmental stress‐induced intestinal ulcers in earthworms

“…These pores can be used to trap pharmaceuticals, biomolecules, or other guest molecules, making MOFs a versatile material for drug delivery, imaging, and other biological applications. 16,17 MOFs can be used for encapsulating drugs and delivering them to specific targets in the body with high efficacy and low negative side effects. 18 MOFs can be designed to target cancer cells or other diseased organs.…”

Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier

“…ZIF-8, the most representative zeolitic imidazolate framework, has a sodalite zeolite-type topology consisting of Zn 2+ ions as secondary building units and 2-methylimidazole as a linker . Recently, ZIF-8 and its composites with other functional materials have been extensively used in various biomedical applications, especially in the drug delivery process, because of their dissolution in acidic or neutral media. − …”