Magnetic Nanoparticles and Rapamycin Encapsulated into Polymeric Nanocarriers

Oliveira, Relton R.; Ferreira, Fabrícia Saba; Cintra, Emílio Ramos; Branquinho, Luis César; Bakuzis, Andris F.; Lima, Eliana Martins

doi:10.1166/jbn.2012.1384

Cited by 35 publications

(17 citation statements)

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“…[78][79][80][81] Gentamicin undergoes controlled release from CS/fucoidan NPs, which renders the NPs into a multiple-function drug delivery system with antibacterial and antioxidant activities that can be used to treat pneumonia. 82 In addition, CS-coated alginate NPs increase the ability of daptomycin to permeate the limbal epithelium of the eye and also increase its ocular accumulation and effect duration.…”

Section: Np-based Antibiotic Delivery Systemsmentioning

confidence: 99%

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang¹,

Hu²,

Shao³

2017

IJN

2,901

1,792

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Nanoparticles (NPs) are increasingly used to target bacteria as an alternative to antibiotics. Nanotechnology may be particularly advantageous in treating bacterial infections. Examples include the utilization of NPs in antibacterial coatings for implantable devices and medicinal materials to prevent infection and promote wound healing, in antibiotic delivery systems to treat disease, in bacterial detection systems to generate microbial diagnostics, and in antibacterial vaccines to control bacterial infections. The antibacterial mechanisms of NPs are poorly understood, but the currently accepted mechanisms include oxidative stress induction, metal ion release, and non-oxidative mechanisms. The multiple simultaneous mechanisms of action against microbes would require multiple simultaneous gene mutations in the same bacterial cell for antibacterial resistance to develop; therefore, it is difficult for bacterial cells to become resistant to NPs. In this review, we discuss the antibacterial mechanisms of NPs against bacteria and the factors that are involved. The limitations of current research are also discussed.

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Section: Np-based Antibiotic Delivery Systemsmentioning

confidence: 99%

The antimicrobial activity of nanoparticles: present situation and prospects for the future

Wang¹,

Hu²,

Shao³

2017

IJN

2,901

1,792

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“…In recent years, magnetic nanoparticles have attracted a great deal of interest in various fields of advanced biological and medical applications, such as RNA and DNA purification, immunoassays, cell isolation, and DNA detection. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Based on using magnetic nanoparticles as target DNA carrier, we have developed couple of genotyping methods previously which avoid any complex procedure including purification and concentration, [43][44] however, it still requires two types of labeled probes for each SNP locus, it increase the cost on the reagents when doing multiplexing analysis.…”

Section: Introductionmentioning

confidence: 99%

An Automatic High-Throughput Single Nucleotide Polymorphism Genotyping Approach Based on Universal Tagged Arrays and Magnetic Nanoparticles

Li¹,

Liu²,

Jia³

et al. 2013

Journal of Biomedical Nanotechnology

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Recent developments in highly parallel genome-wide studies are transforming the association of human health and diseases. In these studies, multiple SNP loci from large amount of samples need to be investigated to obtain a result with a high degree of confidence. Herein, we describe a novel, cost-effective and automated method for high-throughput single nucleotide polymorphisms (SNPs) genotyping based on universal tagged array and magnetic separation. By using two kinds of functionalized magnetic nanoparticles, the whole operation procedure including genome DNA extraction and SNP genotyping can be automatically performed by JANUS automated workstation (Perkin Elmer Inc.). Four different SNPs loci from 80 samples were scored using only one pair of universal dual-color probes, the phase of numerous SNPs can be automated assessed simultaneously. The results demonstrated that the expected scores and good discrimination were obtained between the two alleles from these four SNP loci. Due to adequately taking the advantages of high parallel read-out and intrinsically scalable properties of microarray, and the automated magnetic separation handling technology is highly adaptable fro multiplexing sample preparation and automated SNP analysis, also avoid the complex procedure including purification and concentration, the new strategy is high-throughput, simple, flexible, cost-effective, and will be very suitable for large-scale genotyping.

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“…8 Recently iron oxide nanoparticles have still been applied in biomedicine such as magnetic resonance imaging, chemiluminescence molecular detection, and so on. [9][10][11][12][13][14] In the past few years, iron oxide * Author to whom correspondence should be addressed. nanostructures including nanocubes, 15 16 nanorods, [17][18][19] nanobelts, 20 21 nanotubes, [22][23][24] nanoflowers, 25 nanorings, 26 dendritic micro-pines, 27 and nanoparticles 28 have been prepared.…”

Section: Introductionmentioning

confidence: 99%

Gas Sensors Based on α-Fe2O3 Nanorods, Nanotubes and Nanocubes

Tao¹,

Gao²,

Di³

et al. 2013

j. nanosci. nanotech.

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Nanorods, nanotubes, and nanocubes of alpha-Fe2O3 were synthesized via a hydrothermal process and subsequent calcination treatment. The typical nanorod has about 71 nm in width, 7 nm in thickness, and 314 nm in length. The nanotube has outer diameter of 90-110 nm, inner diameter of 40-80 nm, and lengths of 250-400 nm. The nanocubes are rhombus cubes with an edge length of about 680 nm. The nanorods, nanotubes and nanocubes were fabricated into chemiresistive sensors. The responses (R(a)/R(g)) of the nanotube sensor to ethanol, acetone, formaldehyde, and ammonia are greatly higher than those of the nanorod/the nanocube sensors. The nanotubes showed enhancing gas-sensitive properties. The responses of the nanotube sensor reached 75, 26, 6.8, 1.7 to 200 ppm acetone, ethanol, formaldehyde, and ammonia at 270 degrees C and a 30-45% relative humidity, respectively, which shows high selectivity. So the nanotubes are gas-sensing materials more excellent than nanorods and nanocubes.

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Magnetic Nanoparticles and Rapamycin Encapsulated into Polymeric Nanocarriers

Cited by 35 publications

References 0 publications

The antimicrobial activity of nanoparticles: present situation and prospects for the future

The antimicrobial activity of nanoparticles: present situation and prospects for the future

An Automatic High-Throughput Single Nucleotide Polymorphism Genotyping Approach Based on Universal Tagged Arrays and Magnetic Nanoparticles

Gas Sensors Based on <I>α</I>-Fe<SUB>2</SUB>O<SUB>3</SUB> Nanorods, Nanotubes and Nanocubes

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