Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

Gavilán, Helena; Avugadda, Sahitya Kumar; Fernández‐Cabada, Tamara; Soni, Nisarg; Cassani, Marco; Binh, Thanh; Chantrell, R.W.; Pellegrino, Teresa

doi:10.1039/d1cs00427a

Cited by 227 publications

(215 citation statements)

References 448 publications

(550 reference statements)

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“…When the particle size of magnetite is smaller than 20 nm, it exhibits superparamagnetic behaviour, with high magnetic susceptibility [ 16 ]. In recent years, magnetite nanoparticles have been used as a contrast agent in magnetic resonance imaging [ 17 , 18 , 19 ], as well as in clinical trials for thermotherapy of tumours, as they can generate heat upon external application of an alternating magnetic field [ 20 , 21 ]. In addition, several drug shuttles based on magnetite nanoparticles have been obtained either by functionalising the surface of the nanoparticles with organic molecules—able to form complexes or conjugates with drugs [ 22 , 23 , 24 ]—or by coating the nanoparticles with layers of macromolecules on which drugs can be adsorbed [ 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery

et al. 2022

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Magnetically driven nanosponges with potential application as targeted drug delivery systems were prepared via the addition of magnetite nanoparticles to the synthesis of cyclodextrin and maltodextrin polymers crosslinked with 1,1′-carbonyldiimidazole. The magnetic nanoparticles were obtained separately via a coprecipitation mechanism involving inorganic iron salts in an alkaline environment. Four composite nanosponges were prepared by varying the content of magnetic nanoparticles (5 wt% and 10 wt%) in the cyclodextrin- and maltodextrin-based polymer matrix. The magnetic nanosponges were then characterised by FTIR, TGA, XRD, FESEM, and HRTEM analysis. The magnetic properties of the nanosponges were investigated via magnetisation curves collected at RT. Finally, the magnetic nanosponges were loaded with doxorubicin and tested as a drug delivery system. The nanosponges exhibited a loading capacity of approximately 3 wt%. Doxorubicin was released by the loaded nanosponges with sustained kinetics over a prolonged period of time.

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Section: Introductionmentioning

confidence: 99%

Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery

et al. 2022

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“…MNPs have been shown to be extremely valuable tools, with a wide variety of uses in engineering 16 , 34 , 35 and medicine. 1 , 36–38 They have been utilized as reusable catalysts, 39 , 40 in situ diagnostic agents, 41 contrast agents for magnetic resonance imaging, 42 and for therapeutic hyperthermia 14 , 16 , 21 , 43 , 44 – to name but a few noteworthy examples. In response to the application of a magnetic field, MNPs form chains then clusters which move at varying speeds depending on the magnetic properties of the particles, internal particle–particle interactions, particle–surface interactions, and magnetic field conditions.…”

Section: Discussionmentioning

confidence: 99%

Parallel Multichannel Assessment of Rotationally Manipulated Magnetic Nanoparticles

Hussain

Mair

Willis

et al. 2022

NSA

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Background Rotational manipulation of chains or clusters of magnetic nanoparticles (MNPs) offers a means for directed translation and payload delivery that should be explored for clinical use. Multiple MNP types are available, yet few studies have performed side-by-side comparisons to evaluate characteristics such as velocity, movement at a distance, and capacity for drug conveyance or dispersion. Purpose Our goal was to design, build, and study an electric device allowing simultaneous, multichannel testing (e.g., racing) of MNPs in response to a rotating magnetic field. We would then select the “best” MNP and use it with optimized device settings, to transport an unbound therapeutic agent. Methods A magnetomotive system was constructed, with a Helmholtz pair of coils on either side of a single perpendicular coil, on top of which was placed an acrylic tray having multiple parallel lanes. Five different MNPs were tested: graphene-coated cobalt MNPs (TurboBeads™), nickel nanorods, gold-iron alloy MNPs, gold-coated Fe 3 O 4 MNPs, and uncoated Fe 3 O 4 MNPs. Velocities were determined in response to varying magnetic field frequencies (5–200 Hz) and heights (0–18 cm). Velocities were normalized to account for minor lane differences. Doxorubicin was chosen as the therapeutic agent, assayed using a CLARIOstar Plus microplate reader. Results The MMS generated a maximal MNP velocity of 0.9 cm/s. All MNPs encountered a “critical” frequency at 20–30 Hz. Nickel nanorods had the optimal response based on tray height and were then shown to enable unbound doxorubicin dispersion along 10.5 cm in <30 sec. Conclusion A rotating magnetic field can be conveniently generated using a three-coil electromagnetic device, and used to induce rotational and translational movement of MNP aggregates over mesoscale distances. The responses of various MNPs can be compared side-by-side using multichannel acrylic trays to assess suitability for drug delivery, highlighting their potential for further in vivo applications.

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“…In particular, the two main energy sources being used to generate heat with nanoparticles are near-infrared (NIR) laser light, for photothermal therapy, 9 and alternating magnetic fields for magnetic hyperthermia. 10 …”

Section: Introductionmentioning

confidence: 99%

Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles

et al. 2022

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Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer

Abstract: Magnetic hyperthermia (MHT) exploits magnetic nanoparticles (MNPs) to burn solid tumors. Here, we overview promising MNPs and magnetic assemblies used in MHT alone or in combination with chemotherapy, radiotherapy, immunotherapy or phototherapy.

Cited by 227 publications

References 448 publications

Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery

Magnetic Composites of Dextrin-Based Carbonate Nanosponges and Iron Oxide Nanoparticles with Potential Application in Targeted Drug Delivery

Parallel Multichannel Assessment of Rotationally Manipulated Magnetic Nanoparticles

Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles

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