Magnetic nanoparticle-supported organocatalysis

Abstract

Magnetic nanoparticle (MNP)-supported catalysis is a new method to facilitate catalyst separation and reuse. This technique has recently been introduced for organocatalysis. MNP-supported organocatalysts have been evaluated for their activity, selectivity, and recyclability in a range of chemical transformations, especially for asymmetric synthesis. The synthesis and application of Fe 3 O 4 MNP-supported organocatalysis are highlighted in this short review article.

Magnetic nanoparticle supports for asymmetric catalysts

“…[24][25][26] In the catalysis arena, a sustained effort has been made to develop eco-friendly strategies to generate these nanomaterials via pathways that use benign reagents. 27 Recently, several reports have shown that many reactions can be conducted by using immobilized MNP catalytic systems, [27][28][29][30][31][32][33] with the advantages of the heterogeneous catalysts mentioned above and applicable in asymmetric synthesis, by the use of chiral-ligand-modified or organocatalyst-bonded MNPs as asymmetric catalysts. However, these papers mention asymmetric reaction together with many others, so a critical review focused on this topic is still lacking.…”

l-Leucine supported on superparamagnetic silica-encapsulated γ-Fe2O3nanoparticles: design, characterization, and application as a green catalyst for highly efficient synthesis of thiazoloquinolines

“…Nanoparticles are widely used for organic synthesis. 1 Due to their nanometer size and magnetic properties, they are effective as homogeneous-like systems that integrate the advantages of high dispersion, high reactivity, and simple separation. 2 Magnetic nanoparticles (MNPs) have been well employed to immobilize organic ligands, organocatalysts, and biocatalysts through absorption or formation of covalent bonds.…”

“…2 Magnetic nanoparticles (MNPs) have been well employed to immobilize organic ligands, organocatalysts, and biocatalysts through absorption or formation of covalent bonds. 1 Moreover, MNPs such as iron oxide have a high surface area, superior thermal and chemical stability, surface modication ability, ease of synthesis, and low toxicity and cost. 3 Researchers' attention has been drawn to immobilization of amino acids on the surface of nanoparticles.…”