Magnetic Nanoparticle-Mediated Heating for Biomedical Applications

Abstract

Magnetic nanoparticles, especially superparamagnetic nanoparticles (SPIONs), have attracted tremendous attention for various biomedical applications. Facile synthesis and functionalization together with easy control of the size and shape of SPIONS to customize their unique properties, have made it possible to develop different types of SPIONs tailored for diverse functions/applications. More recently, considerable attention has been paid to the thermal effect of SPIONs for the treatment of diseases like cancer and for nanowarming of cryopreserved/banked cells, tissues, and organs. In this mini-review, recent advances on the magnetic heating effect of SPIONs for magnetothermal therapy and enhancement of cryopreservation of cells, tissues, and organs, are discussed, together with the non-magnetic heating effect (i.e., high Intensity focused ultrasound or HIFU-activated heating) of SPIONs for cancer therapy. Furthermore, challenges facing the use of magnetic nanoparticles in these biomedical applications are presented.

Nano drugs delivery system: A novel promise for the treatment of atrial fibrillation

“…In addition, if hyperthermic heating of cells is insufficient, polymer coatings with higher critical temperatures can also be designed to release endotoxins by heating the particles with an alternating magnetic field, thereby providing additional targeted killing for drug delivery ( 96 , 97 ).…”

Magnetic nanoparticles for nanowarming: seeking a fine balance between heating performance and biocompatibility

“…35 The synthesis and basic heating performance of magnetic nanomaterials used in magnetic hyperthermia have been well reviewed. 9,11 However, it is important to note that although magnetic nanoparticles used for hyperthermia and nanowarming share similarities, their applications and requirements may lead to differences in their properties and heating performance. Two basic factors need to be considered when designing nanowarming agents: heating performance at low temperatures and acute toxicity (Fig.…”

“…9,10 Magnetic induction heating has been widely used in many fields, such as cancer therapy, drug delivery, and energy conversion. [11][12][13][14] One notable new application is using magnetic nanoparticles as a heating source for thawing cryopreserved biological tissues and organs. This technique is known as nanowarming, first developed by Bischof et al in 2017.…”

Nanomedicines for high‑intensity focused ultrasound cancer treatment and theranostics (Review)

“…As boiling temperatures also affect the phase-shifting temperature of constructed nanomaterials ( 61 , 62 ), there remain challenges before these can be used clinically. As the phase shifting temperature of PFP is lower than that of PFH (>40 vs. >60˚C), PFP may be a better choice for nanomaterial construction, as lower HIFU irradiation doses can be used ( 63 ). Zhang et al ( 64 ) constructed a poly(lactide-co-glycolic acid) (PLGA) NP that incorporated PFP and hematoporphyrin monomethyl ether (HMME) as synergistic agents (HMME + PFP/PLGA) for HIFU ablation.…”