Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications

Demir, Didem; Güreş, Dilek; Tecim, Tuğba; Genç, Rükan; Bölgen, Nimet

doi:10.1007/s13204-018-0830-9

Cited by 36 publications

(30 citation statements)

References 24 publications

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“…As a result, a greater charge can be affected by the electrospinning jet, which can then affect the fiber morphology. A similar result was reported by Demir et al [45], who found that by increasing the concentration of the magnetic nanoparticles in a poly(e-caprolactone) (PCL) solution from a 1:25 to a 32:25 weight ratio, the fiber diameter changed and bead formation occurred.…”

Section: Resultssupporting

confidence: 87%

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Yalçinkaya

Komárek

2019

IJMS

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In this study, nanoparticle-incorporated nanofiber-covered yarns were prepared using a custom-made needle-free electrospinning system. The ultimate goal of this work was to prepare functional nanofibrous surfaces with antibacterial properties and realize high-speed production. As antibacterial agents, we used various amounts of copper oxide (CuO) and vanadium (V) oxide (V2O5) nanoparticles (NPs). Three yarn preparation speeds (100 m/min, 150 m/min, and 200 m/min) were used for the nanofiber-covered yarn. The results indicate a relationship between the yarn speed, quantity of NPs, and antibacterial efficiency of the material. We found a higher yarn speed to be associated with a lower reduction in bacteria. NP-loaded nanofiber yarns were proven to have excellent antibacterial properties against Gram-negative Escherichia coli (E. coli). CuO exhibited a greater inhibition and bactericidal effect against E. coli than V2O5. In brief, the studied samples are good candidates for use in antibacterial textile surface applications, such as wastewater filtration. As greater attention is being drawn to this field, this work provides new insights regarding the antibacterial textile surfaces of nanofiber-covered yarns.

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Section: Resultssupporting

confidence: 87%

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Yalçinkaya

Komárek

2019

IJMS

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“…However, the authors stated that both solution viscosity and electrical conductivity increased remarkably when the magnetic nanoparticle concentration increased from 0 to 1 wt%. Similarly, Demir, Güreş, Tecim, Genç and Bölgen (2018) demonstrated that the increase in Fe 3 O 4 nanoparticle concentration resulted in a decrease in the viscosity of PCL solution, leading to bead formation. Additionally, a further increment in nanoparticle concentration caused discontinuous and heterogeneity in fibers, probably because of the overload in concentration.…”

Section: Resultsmentioning

confidence: 92%

Zero‐valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering

Sezer

Yavuz

Ors

et al. 2020

J Tissue Eng Regen Med

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Regeneration of nerve tissue is a challenging issue in regenerative medicine. Especially, the peripheral nerve defects related to the accidents are one of the leading health problems. For large degeneration of peripheral nerve, nerve grafts are used in order to obtain a connection. These grafts should be biodegradable to prevent second surgical intervention. In order to make more effective nerve tissue engineering materials, nanotechnological improvements were used. Especially, the addition of electrically conductive and biocompatible metallic particles and carbon structures has essential roles in the stimulation of nerves. However, the metabolizing of these structures remains to wonder because of their nondegradable nature. In this study, biodegradable and conductive nerve tissue engineering materials containing zero‐valent iron (Fe) nanoparticles were developed and investigated under in vitro conditions. By using electrospinning technique, fibrous mats composed of electrospun poly(ε‐caprolactone) (PCL) nanofibers and Fe nanoparticles were obtained. Both electrical conductivity and mechanical properties increased compared with control group that does not contain nanoparticles. Conductivity of PCL/Fe5 and PCL/Fe10 increased to 0.0041 and 0.0152 from 0.0013 Scm−1, respectively. Cytotoxicity results indicated toxicity for composite mat containing 20% Fe nanoparticles (PCL/Fe20). SH‐SY5Y cells were grown on PCL/Fe10 best, which contains 10% Fe nanoparticles. Beta III tubulin staining of dorsal root ganglion neurons seeded on mats revealed higher cell number on PCL/Fe10. This study demonstrated the impact of zero‐valent Fe nanoparticles on nerve regeneration. The results showed the efficacy of the conductive nanoparticles, and the amount in the composition has essential roles in the promotion of the neurites.

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“…Since these parameters were constant for PCPN, PCPN10 and PCPN 20, it can be concluded that the MNP concentration plays the important role in the fiber morphology. [ 33 ] As can be seen the PCPN fibers appear to have a bead‐free smooth surface with an average diameter of 569 ± 195 nm. During electrospining, the MNPs could either be incorporated within the fibers or appear on the surface of the magnetic scaffolds giving it a unique surface texture/topography.…”

Section: Resultsmentioning

confidence: 98%

Poly(Caprolactone)‐Poly(N‐Isopropyl Acrylamide)‐Fe₃O₄ Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release

Gholami

Labbaf

Kermanpur

et al. 2020

Macro Materials & Eng

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Poly(caprolactone; PCL)—poly(N‐isopropylacrylamie; PNIPAAm)—Fe3O4 fiber, that can be magnetically actuated, is reported. Here, a structure is engineered that can be utilized as a smart carrier for the release of chemotherapeutic drug via magneto‐thermal activation, with the aid of magnetic nanoparticles (MNPs). The magnetic measurement of the fibers revealed saturation magnetization values within the range of 1.2–2.2 emu g−1. The magnetic PCL‐PNIPAAm‐Fe3O4 scaffold shows a specific loss power value of 4.19 W g−1 at 20 wt% MNPs. A temperature increase of 40 °C led to a 600% swelling after only 3 h. Doxorubicin (DOX) as a model drug, demonstrates a controllable drug release profile. 39% ± 0.92 of the total drug loaded is released after 96 h at 37 °C, while 25% drug release in 3 h at 40 °C is detected. Cytotoxicity results show no significant difference in cell attachment efficiency between the MNP‐loaded fibers and control while the DOX‐loaded fibers effectively inhibited cell proliferation at 24 h matching the drug release profile. The noncytotoxic effect, coupled with the magneto‐thermal property and controlled drug release, renders excellent potential for these fibers to be used as a smart drug‐release agent for localized cancer therapy.

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Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications

Cited by 36 publications

References 24 publications

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Zero‐valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering

Poly(Caprolactone)‐Poly(N‐Isopropyl Acrylamide)‐Fe₃O₄ Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release

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Magnetic nanoparticle-loaded electrospun poly(ε-caprolactone) nanofibers for drug delivery applications

Cited by 36 publications

References 24 publications

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Polyvinyl Butyral (PVB) Nanofiber/Nanoparticle-Covered Yarns for Antibacterial Textile Surfaces

Zero‐valent iron nanoparticles containing nanofiber scaffolds for nerve tissue engineering

Poly(Caprolactone)‐Poly(N‐Isopropyl Acrylamide)‐Fe3O4 Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release

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Product

Resources

About

Poly(Caprolactone)‐Poly(N‐Isopropyl Acrylamide)‐Fe₃O₄ Magnetic Nanofibrous Structure with Stimuli Responsive Drug Release