Magnetic Nanoparticle Hyperthermia in Cancer Treatment

Giustini, Andrew J.; Petryk, Alicia A.; Cassim, Shiraz M.; Tate, Jennifer A.; Baker, I.; Hoopes, P. Jack

doi:10.1142/s1793984410000067

Cited by 314 publications

(189 citation statements)

References 120 publications

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“…2 In a clinical setting, hyperthermia is predominantly used in conjunction with other forms of cancer therapy, such as radiation therapy and chemotherapy. [3][4][5][6] Magnetic nanoparticle (MNP) hyperthermia as a cancer therapy operates on the principle that magnetic nanoparticles introduced into a tumor produce heat when subjected to an alternating magnetic field (AMF). There are a number of MNPs with different shapes and magnetic properties for Hyperthermia applications.…”

mentioning

confidence: 99%

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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Magnetic nanoparticles (MNPs), referred to as the Dartmouth MNPs, which exhibit high specific absorption rate at low applied field strength have been developed for hyperthermia therapy applications. The MNPs consist of small (2-5 nm) single crystals of gamma-FeO with saccharide chains implanted in their crystalline structure, forming 20-40 nm flower-like aggregates with a hydrodynamic diameter of 110-120 nm. The MNPs form stable (>12 months) colloidal solutions in water and exhibit no hysteresis under an applied quasistatic magnetic field, and produce a significant amount of heat at field strengths as low as 100 Oe at 99-164 kHz. The MNP heating mechanisms under an alternating magnetic field (AMF) are discussed and analyzed quantitatively based on (a) the calculated multi-scale MNP interactions obtained using a three dimensional numerical model called the method of auxiliary sources, (b) measured MNP frequency spectra, and (c) quantified MNP friction losses based on magneto-viscous theory. The frequency responses and hysteresis curves of the Dartmouth MNPs are measured and compared to the modeled data. The specific absorption rate of the particles is measured at various AMF strengths and frequencies, and compared to commercially available MNPs. The comparisons demonstrate the superior heating properties of the Dartmouth MNPs at low field strengths (<250 Oe). This may extend MNP hyperthermia therapy to deeper tumors that were previously non-viable targets, potentially enabling the treatment of some of the most difficult cancers, such as pancreatic and rectal cancers, without damaging normal tissue.

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confidence: 99%

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Shubitidze

Kekalo

Stigliano

et al. 2015

Journal of Applied Physics

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“…reported that MHT significantly increases cell membrane fluidity and this can be a factor contributing to the increase of CDDP uptake in MHT-treated Caco-2 cells. Furthermore, it has been reported that blood flow increases when MHT is applied and this helps to accumulate anti-cancer drugs within the heated tissue 17) . Although copper transporter receptors might have a crucial role in the uptake of CDDP by cancer cells, the above synergistic effect of MHT and CDDP would be largely related to the increase of cell membrane fluidity 16) and/or the increase of blood flow 17) .…”

Section: Therapeutic Effectmentioning

confidence: 99%

Magnetic Particle Imaging for Quantitative Evaluation of Tumor Response to Magnetic Hyperthermia Treatment Combined with Chemotherapy Using Cisplatin

Ohki¹,

Tanoue²,

Kobayashi³

et al. 2017

Thermal Med.

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This study was undertaken to evaluate the tumor response to magnetic hyperthermia treatment (MHT) combined with cisplatin (MHT ＋CDDP ) using magnetic particle imaging (MPI). Colon-26 cells were implanted into the backs of mice. When the tumor volume exceeded approximately 100 mm 3 , the mice were divided into control, MHT, CDDP, and MHT＋CDDP groups. In the CDDP and MHT＋CDDP groups, CDDP (5 mg/kg) was injected intraperitoneally. In the MHT＋CDDP group, magnetic nanoparticles ［250 mM (14.0 mg Fe/mL) Resovist ® ］ were directly injected into the tumor one hour after CDDP administration, and MHT was performed for 20 min using an alternating magnetic field. In the MHT group, only MHT was performed after the injection of Resovist ® . In the MHT＋CDDP and MHT groups, MPI images were obtained using our MPI scanner immediately before, immediately after, and 3, 7, and 14 days after MHT. After the MPI studies, we drew a region of interest (ROI) on the tumor in the MPI image and calculated the average and maximum MPI values and the number of pixels within the ROI. In all groups, the relative tumor volume growth (RTVG) was calculated from (V-V 0 ) /V0, where V 0 and V were the tumor volumes immediately before and after treatment, respectively. The RTVG value in the MHT＋CDDP group was significantly lower than that in the MHT group 3 to 14 days after MHT. It was also significantly lower than that in the CDDP group at 4 to 11 days except at 6 and 9 days after treatment. The average and maximum MPI values normalized by those immediately before MHT in the MHT＋CDDP group were significantly higher than those in the MHT group 3 days after MHT. Our results suggested that MPI is useful for quantitatively evaluating tumor response to MHT combined with chemotherapy. magnetic particle imaging, magnetic hyperthermia treatment, magnetic nanoparticles, cisplatin, tumor response

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“…Mesmo com o avanço da ciência, não se tem a garantia de haver um tratamento completamente eficiente contra a doença (SIEGEL et al, 2012). Devido à grande variedade de tipos de câncer e a especificidade do combate a cada um deles, existem diversas técnicas aplicada no tratamento oncológico, por exemplo, quimioterapia, radiação e cirurgia (GIUSTINI et al, 2010). Todas essas técnicas possuem vantagens e desvantagens associadas aos recursos empregados, porém, destas se destaca a falta de seletividade das drogas aplicadas em tratamentos contra câncer específicos.…”

Section: Tratamento Oncológico: Hipertermiaunclassified

“…Quando associada à nanotecnologia essa técnica se mostra particularmente eficiente na indução da apoptose ou enfraquecimento de células tumorais. Isso se dá em função de nanopartículas magnéticas, que, devido à alternância do campo magnético, consegue aquecer até a temperatura desejada (GIUSTINI et al, 2010).…”

Section: Tratamento Oncológico: Hipertermiaunclassified

Síntese E Caracterização De Nanoesferas De Poliestireno Para Encapsulamento De Nanoparticulado Magnético

Elyseu¹,

Dumont²,

Ferreira³

2017

JCEC

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Magnetic Nanoparticle Hyperthermia in Cancer Treatment

Cited by 314 publications

References 120 publications

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Magnetic nanoparticles with high specific absorption rate of electromagnetic energy at low field strength for hyperthermia therapy

Magnetic Particle Imaging for Quantitative Evaluation of Tumor Response to Magnetic Hyperthermia Treatment Combined with Chemotherapy Using Cisplatin

Síntese E Caracterização De Nanoesferas De Poliestireno Para Encapsulamento De Nanoparticulado Magnético

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