Magnetic nanoparticle-driven pumping in microchannels

Use of Negative Dielectrophoresis for Selective Elution of Protein-Bound Particles

“…In order to develop a true high throughput microfluidic bioanalysis platform, an important requirement is the ability to independently control the movement of fluids and various other bioparticles in an addressable manner, similar to the ability to control the movement of current in an integrated electronic circuit. To date, several well established methods have been developed, each with its' own advantages and disadvantages, including on-chip pneumatic valves 12 , various electrokinetic methods 13 , and also magnetic manipulation 14, 15 . Each of the above listed methods may be appropriate for a set of applications, while being inappropriate for others.…”

“…To date, several well-established methods have been developed, each with its own advantages and disadvantages, including onchip pneumatic valves, 12 various electrokinetic methods, 13 and also magnetic manipulation. 14,15 Each of the above listed methods may be appropriate for a set of applications, while being inappropriate for others. On-chip pneumatic microfluidic valves, for example, are very versatile and rapid and have proven quite successful; however, the disadvantage is that the requirement for a large number of tubes for controlling the flow required can become a plumber's nightmare as the number of control channels becomes large.…”

“…In order to develop a true high-throughput microfluidic bioanalysis platform, an important requirement is the ability to independently control the movement of fluids and various other bioparticles in an addressable manner, similar to the ability to control the movement of current in an integrated electronic circuit. To date, several well-established methods have been developed, each with its own advantages and disadvantages, including on-chip pneumatic valves, various electrokinetic methods, and also magnetic manipulation. , Each of the above listed methods may be appropriate for a set of applications, while being inappropriate for others. On-chip pneumatic microfluidic valves, for example, are very versatile and rapid and have proven quite successful; however, the disadvantage is that the requirement for a large number of tubes for controlling the flow required can become a plumber’s nightmare as the number of control channels becomes large.…”

Device for Controlled Distribution of FePt Nanoparticles Formations in a Stream of Liquid Medium under Influence of Magnetic Field

“…Because the aim was to investigate the operation of the magnetic device, in this case magnetic particles (custom tailored in Tokyo Institute of Technology, prof. Y. Kitamoto's laboratory) comprising the injectable magnetic suspension did not have any coating as it was not necessary. Although it is known that chemical stability of magnetic nanoparticles is possible to achieve by appropriate coating of for example biocompatible dextran matrix [22] so it would be safe to use in human vascular system. FePt particles (Fig.…”